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Check availability on Downtown San Francisco Business Hotels

Our top choices for Downtown San Francisco business-friendly hotels

Front of property – evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
Downtown San Francisco
8.6 out of 10, Excellent, (2116)
"Great stay "
United States
Samantha
The price is 2.461.235 ₫
2.896.751 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton San Francisco Financial District
Exterior detail
Hilton San Francisco Union Square

Hilton San Francisco Union Square

Hilton San Francisco Union Square
4.0 star property
Union Square
8.4 out of 10, Very good, (1125)
"The hotel was centrally located and a safe place to stay."
United States
Paulette
The price is 3.432.775 ₫
5.124.959 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Hilton San Francisco Union Square
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
Union Square
9.4 out of 10, Exceptional, (3060)
"Best location, friendly staff, had a wonderful time stayed! "
United States
Kalinda
The price is 1.994.157 ₫
2.356.300 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Chancellor Hotel on Union Square
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (2796)
"Clean and comfortable room, good staff, great location. "
United Kingdom
David
The price is 2.640.272 ₫
3.107.468 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Club Quarters Hotel in San Francisco
Exterior
King George Hotel

King George Hotel

King George Hotel
3.0 star property
Union Square
8.6 out of 10, Excellent, (2101)
"What a wonderful stay completely recommend Daya was amazing"
United States
Glenda
The price is 2.299.385 ₫
3.101.429 ₫ total
includes taxes & fees
20 Dec - 21 Dec
King George Hotel
Exterior
Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1295)
"Overall wonderful experience "
United States
Mary
The price is 4.140.235 ₫
5.923.377 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Hyatt Regency San Francisco Downtown SOMA
Exterior
Hyatt Regency San Francisco

Hyatt Regency San Francisco

Hyatt Regency San Francisco
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (1992)
"Great location and bar"
United States
michael
The price is 4.449.601 ₫
6.447.039 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Hyatt Regency San Francisco
Restaurant
Grand Hyatt San Francisco

Grand Hyatt San Francisco

Grand Hyatt San Francisco
4.0 star property
Union Square
8.8 out of 10, Excellent, (1000)
"Great loved the tub and the shower "
United States
Samantha
The price is 3.528.086 ₫
5.391.950 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Grand Hyatt San Francisco
Outdoor pool, open 9:00 AM to 7:00 PM, pool loungers
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (4958)
"Rooms were great, staff was great, location was great. "
United States
Jonathan
The price is 3.133.151 ₫
3.687.563 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Golden Gateway by IHG
Exterior
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square
4.5 star property
Union Square
8.8 out of 10, Excellent, (2417)
"Always a great place to stay "
United States
Susan
The price is 4.872.708 ₫
6.828.091 ₫ total
includes taxes & fees
26 Dec - 27 Dec
The Westin St. Francis San Francisco on Union Square
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Downtown San Francisco Hotel Reviews

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Frequently asked questions

Why book your business-friendly hotel in Downtown San Francisco with Expedia?
At Expedia, our top task is to help you locate an excellent stay at the right price. From luxurious, corporate-friendly escapes to affordable hotels filled with conveniences, you'll have your next work trip arranged in a couple of clicks.
How can I find cheap business-friendly hotels in Downtown San Francisco?
When work takes you to Downtown San Francisco, our "business friendly" filter will help you find the perfect hotel. From fast WiFi to conference spaces and in-room desks, they have the amenities you need to do your job. You can also refine your search by your preferred star rating and budget to view the most affordable stays.