Otay Mesa West Holidays

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Where to stay in Otay Mesa West

Find the best Otay Mesa West areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa West
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa West

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 4.019.651 ₫ per night from 5 Oct to 6 Oct
4.019.651 ₫
5.426.735 ₫ total
5 Oct - 6 Oct
includes taxes & fees
8.2/10 Very Good! (5,942 reviews)
"Hotel is in a great location right near airport and trolley. Has an airport shuttle, pool, 3 restaurants on site and a few access the street. Best of all the staff and management are really friendly and professional."

Reviewed on 1 Oct 2025

Wyndham San Diego Bayside
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 5.787.075 ₫ per night from 4 Oct to 5 Oct
5.787.075 ₫
8.147.343 ₫ total
4 Oct - 5 Oct
includes taxes & fees
9/10 Wonderful! (2,813 reviews)
"The hotel is nice but more tailored for the convention fare & less of a resort ambiance. Service was efficient yet impersonal & why no concierge? They make a hotel experience."

Reviewed on 22 Sept 2025

Manchester Grand Hyatt San Diego
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is 3.149.145 ₫ per night from 7 Oct to 8 Oct
3.149.145 ₫
3.651.276 ₫ total
7 Oct - 8 Oct
includes taxes & fees
8.6/10 Excellent! (467 reviews)
"Great staff, loved the beds and pillows. Would have loved a nicer pool area, it was clean but very basic. We really liked the proximity to little Italy."

Reviewed on 25 Sept 2025

The DEXTRO Little Italy, BW Premier Collection
See all 6,709 properties in Otay Mesa West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa West holiday package cost?
Discover the best of Otay Mesa West from as little as . Choose from a wonderful selection of flights, hotels and rental cars to suit every style and budget. You can score even better deals when you add some experiences or tours to your package.
How do I get a cheap travel package to Otay Mesa West?
Booking an Otay Mesa West holiday package with Expedia is the easiest way to save. We have over 550 partner airlines and 1null000null000 properties across the globe. With such an awesome range to select from, you'll have no trouble putting together your next dream holiday.
Where should I stay in Otay Mesa West?
You'll want to stay where the action is. Many people book hotels around popular attractions, like Las Americas Premium Outlets, North Island Credit Union Amphitheatre and Aquatica.
How far in advance should I book my Otay Mesa West holiday?
Smart travellers will likely want to book early. You can normally start comparing international fares on Expedia up to a year before your intended flight. If you're booking last minute, don't despair. Low prices sometimes appear just weeks before departure dates.
What does an Expedia Otay Mesa West travel package include?
It all depends on what type of getaway you're contemplating. Otay Mesa West holiday deals can include hotels, car rentals and flights. You can mix and match to find the travel package that fits your needs. You can also add on experiences and activities after you've booked to score even bigger discounts.
What should I know before booking an Otay Mesa West travel package?
Get ready to save with an Expedia travel package. Bundle your airfares, rental cars and hotels and pick up fabulous discounts. You're not limited to hotels, though. Book with us and select from beach villas, mountain cabins and everything in between!
Can I choose my airline with an Otay Mesa West Expedia holiday package?
With a holiday package, you're the boss. Whether you'd like to fly to Otay Mesa West in economy or business class, simply pick from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Otay Mesa West holiday package?
You can. We get that even the best-laid plans can go awry, so we're here to help if you need to make changes to your Otay Mesa West holiday package. You may be able to cancel or change your itinerary for free if you've booked within 24 hours. Your hotel, airline or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for further information. Also, be sure to check your itinerary for the nitty-gritty on change fees.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

Why not visit the animals who live at San Diego Zoo and see why this is a popular attraction in San Diego? Stroll along the area's beautiful beaches or experience its acclaimed theatre scene.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.

San Diego Convention Center
Mission Bay featuring a beach

Mission Bay

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the beautiful beaches in this family-friendly area or visit its top-notch restaurants.

Mission Bay