The Best Hotels in Downtown South San Francisco, San Francisco - 2026 Updated Prices

An aerial view of a city with a large stadium, several schools, and a dense residential area.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

Downtown South San Francisco

Denis

4.001.828 ₫ total

includes taxes & fees

23 Aug - 24 Aug

2. Airport Inn

Downtown South San Francisco

Ernest

3.523.678 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Premium bedding, pillow-top beds, in-room safe, desk

3. Inn By The SFO

Downtown South San Francisco

Marco

2.710.443 ₫ total

includes taxes & fees

11 Sept - 12 Sept

Deluxe Room | 1 bedroom, desk, laptop workspace, iron/ironing board

4. Miller Apartments

Downtown South San Francisco

Lina

3.718.806 ₫ total

includes taxes & fees

21 Aug - 22 Aug

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

The East Side, 1.4 km from Downtown South San Francisco

Alain

4.507.988 ₫ total

includes taxes & fees

11 Sept - 12 Sept

6. DoubleTree by Hilton San Francisco South Airport Blvd

1.5 km from Downtown South San Francisco

Ashley

4.018.358 ₫ total

includes taxes & fees

6 Sept - 7 Sept

7. Best Western Plus Grosvenor Airport Hotel

1.8 km from Downtown South San Francisco

EDDIE

3.146.931 ₫ total

includes taxes & fees

30 Aug - 31 Aug

8. Sonesta Select San Francisco Airport Oyster Point Waterfront

Oyster Point, 2.2 km from Downtown South San Francisco

Renato

3.576.371 ₫ total

includes taxes & fees

23 Aug - 24 Aug

9. Home2 Suites by Hilton San Francisco Airport North

The East Side, 1.5 km from Downtown South San Francisco

Lizset

3.640.313 ₫ total

includes taxes & fees

6 Sept - 7 Sept

10. Bay Landing San Francisco Airport Hotel

7.9 km from Downtown South San Francisco

Satveer

4.461.055 ₫ total

includes taxes & fees

22 Aug - 23 Aug

Business Room, 1 King Bed | Desk, blackout curtains, iron/ironing board, free WiFi

11. Hotel Nova SFO

1.9 km from Downtown South San Francisco

Aarzu

3.848.021 ₫ total

includes taxes & fees

14 Aug - 15 Aug

12. Comfort Inn and Suites San Francisco Airport North

The East Side, 1.1 km from Downtown South San Francisco

Penni

3.075.237 ₫ total

includes taxes & fees

6 Sept - 7 Sept

13. The Millwood - A Boutique Hotel

5.4 km from Downtown South San Francisco

Susan

4.630.251 ₫ total

includes taxes & fees

7 Sept - 8 Sept

14. Aloft by Marriott San Francisco Airport

6.9 km from Downtown South San Francisco

Jeffrey

3.825.410 ₫ total

includes taxes & fees

6 Sept - 7 Sept

Executive Room, 1 King Bed (Premium King Room) | Premium bedding, pillow-top beds, in-room safe, desk

15. Villa Montes Hotel

3.4 km from Downtown South San Francisco

Anna

4.009.958 ₫ total

includes taxes & fees

5 Sept - 6 Sept

16. Hilton San Francisco Airport Bayfront

9.9 km from Downtown South San Francisco

Richard

3.307.504 ₫ total

includes taxes & fees

23 Aug - 24 Aug

17. La Quinta Inn & Suites by Wyndham San Francisco Airport West

5.4 km from Downtown South San Francisco

Colleen

3.721.415 ₫ total

includes taxes & fees

7 Sept - 8 Sept

Hypo-allergenic bedding, pillow-top beds, laptop workspace

18. The Atrium Hotel

3 km from Downtown South San Francisco

SOHAIL

3.825.933 ₫ total

includes taxes & fees

23 Aug - 24 Aug

Standard Room, 2 Queen Beds | In-room safe, desk, laptop workspace, iron/ironing board

19. Hotel Skye SFO

3.9 km from Downtown South San Francisco

Jaspreet

3.527.320 ₫ total

includes taxes & fees

23 Aug - 24 Aug

20. DoubleTree by Hilton San Francisco Airport North Bayfront

3.1 km from Downtown South San Francisco

Robert

3.012.003 ₫ total

includes taxes & fees

10 Sept - 11 Sept

View all properties

Where to stay in Downtown South San Francisco

Find the best Downtown South San Francisco areas for the activities you enjoy most.

A street with shops, including a crystal shop and a crepes cafe.

Fisherman's Wharf

Travellers love Fisherman's Wharf for its popular shops, and you can see more of San Francisco by jumping on the metro at Jones St and Beach St Stop or Jefferson St & Taylor St Stop. You might spend time checking out top sights like Pier 39 and San Francisco Bay.

See properties

A cityscape with tall buildings, a central plaza with palm trees, and a flag on one of the buildings.

Union Square

Known for its charming cafes and popular shops, there's plenty to explore in Union Square. Check out top attractions like Westin St Francis Hotel Glass Elevators and Union Square, and jump on the metro at Powell St & Geary Blvd Stop or Powell St & Post St Stop to see more of the city.

See properties

A trolley on a street with buildings and a clock tower.

Downtown San Francisco

Known for its fascinating museums, popular shops and acclaimed art galleries, there's plenty to explore in Downtown San Francisco. Top attractions like Oracle Park and Chase Center are major draws. Catch the metro at Market St & 5th St Stop or Market St & Taylor St Stop to see more of the city.

See properties

A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

Gourmet restaurants great entertainment and top sights from Oracle Park to Chase Center – discover South of Market, a destination also famous for its shopping.

See properties

A street lined with historic buildings, parked cars, and a clear blue sky.

Nob Hill

Gourmet restaurants Chinatown and top sights from SF Masonic Auditorium to Cable Car Museum – discover Nob Hill, a destination also famous for its shopping.

See properties

Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

8/10 Good

"The breakfast was excellent, good variety and very polite staff that kept it constantly topped up. The hotel also had a grab and go which had coffee, food and snacks until 10 at night.The location made it easy to get around. It was walkable to pier 39 , fisherman’s wharf sign and lots more . There was a tram stop and 2 bus stops nearby. Bus 28 takes you to the bridge and then you can get back on and go to the park. Our room was on a cross road which made it very noisy at night, loud cars constantly driving up and down, the tram and lots of other noise which of course isn’t the hotels fault , it’s just because it is so near to the front. There are quite a lot of homeless in the city and they are often around the fire pits at the hotel but we never had a problem with them."

Handlery Union Square Hotel

10/10 Excellent

"Excellent location, charming early 1900’s classic vibe, very clean, cozy and the staff are really extra nice. We’ll definitely be back. Close public parking garage for $38/day if you don’t need the car or $43/day if you need in/out parking. This is much less than typical downtown SF hotel valet parking. Great restaurants all over the area too!"

Chancellor Hotel on Union Square

10/10 Excellent

"This is a hidden gem! We were somewhat leery booking this property because the price was $150 for the night. What we experienced was a great boutique style hotel. The room was smaller but had a large walk in closet, which you don’t see in hotels. This allowed us to put luggage in there and made the room feel bigger. Highly recommend staying here!"

Frequently asked questions

What's it like in Downtown South San Francisco?

You'll be sure to have fun exploring South San Francisco's Downtown South San Francisco neighbourhood.

How many hotels should I expect to find in the Downtown South San Francisco area?

When you want to put your feet up after a day of exploring the sights in South San Francisco, you can choose from 10 Expedia hotels and other accommodation options in Downtown South San Francisco.

If I need to cancel my hotel reservation in Downtown South San Francisco, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the best options available in Downtown South San Francisco.

What can I see and do in this South San Francisco neighbourhood?

South San Francisco Hillside Sign, Sign Hill Park and See's Candies are just a few of the places to visit in and around Downtown South San Francisco. Cinemark Century at Tanforan and K1 Speed San Francisco are also worth a visit when you're out sightseeing in South San Francisco.

Search Hotels in Downtown South San Francisco, San Francisco

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Downtown South San Francisco hotels

1. La Quinta Inn & Suites by Wyndham San Francisco Airport N

2. Airport Inn

3. Inn By The SFO

4. Miller Apartments

5. Embassy Suites by Hilton San Francisco Airport Oyster Point

6. DoubleTree by Hilton San Francisco South Airport Blvd

7. Best Western Plus Grosvenor Airport Hotel

8. Sonesta Select San Francisco Airport Oyster Point Waterfront

9. Home2 Suites by Hilton San Francisco Airport North

10. Bay Landing San Francisco Airport Hotel

11. Hotel Nova SFO

12. Comfort Inn and Suites San Francisco Airport North

13. The Millwood - A Boutique Hotel

14. Aloft by Marriott San Francisco Airport

15. Villa Montes Hotel

16. Hilton San Francisco Airport Bayfront

17. La Quinta Inn & Suites by Wyndham San Francisco Airport West

18. The Atrium Hotel

19. Hotel Skye SFO

20. DoubleTree by Hilton San Francisco Airport North Bayfront

Where to stay in Downtown South San Francisco

Fisherman's Wharf

Union Square

Downtown San Francisco

South of Market

Nob Hill

Top Downtown South San Francisco Hotel Reviews

Hotel Riu Plaza Fisherman's Wharf

Frequently asked questions

Explore a world of travel with Expedia