Serra Mesa Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
US Grant Hotel

Downtown San Diego

4 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Serra Mesa

Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is 6.231.437 ₫ per night from 5 Apr to 6 Apr
6.231.437 ₫
8.556.734 ₫ total
5 Apr - 6 Apr
includes taxes & fees
8.6/10 Excellent! (2,476 reviews)
The location is very beautiful. The property sits on the water and has great views. The rooms are good size. The food was just ok, the location of the restaurant and bar are again very pretty . We waited 40 minutes one night to get some bread and a salad. We kept getting other people’s orders that ...

Reviewed on 25 Mar 2026

Paradise Point Resort & Spa
Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
Fully refundableReserve now, pay when you stay
The price is 2.157.755 ₫ per night from 1 Apr to 2 Apr
2.157.755 ₫
2.480.231 ₫ total
1 Apr - 2 Apr
includes taxes & fees
7.8/10 Good! (3,334 reviews)
Good location. Clean. Security on site.

Reviewed on 25 Mar 2026

Best Western Seven Seas
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is 4.826.954 ₫ per night from 2 Apr to 3 Apr
4.826.954 ₫
6.868.108 ₫ total
2 Apr - 3 Apr
includes taxes & fees
9/10 Wonderful! (3,433 reviews)
Staff was friendly and the view from our room was spectacular

Reviewed on 25 Mar 2026

Hard Rock Hotel San Diego
See all 9,020 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Serra Mesa holiday package cost?
Be ready to book, because a trip to Serra Mesa starts from just . When you bundle your hotels, flights and car rentals into a package, you'll land the lowest prices.
How do I get a cheap travel package to Serra Mesa?
One of the simplest ways to save dollars (and time) is to bundle your bookings with Expedia. Flights, hotels, activities and rental cars — we've got everything you need. Pick the combination that best suits you and watch your savings pile up. Of course, a travel package is never one-size-fits-all. That's why we offer more than 550 partner airlines and 1null000null000 hotel options worldwide, which lets you customize your Serra Mesa holiday.
Where should I stay in Serra Mesa?
Most visitors to Serra Mesa put both San Diego Zoo and Balboa Park on their itineraries. Why not go for a hotel that's close to these fantastic attractions?
What are the top hotels in Serra Mesa?
Get your escape off to an excellent start by locking in a room at Central Location - 3br/2ba. Stay Weekly. Clean. It's one of most sought-after properties in Serra Mesa. Another comfortable option is Newly Remodeled Beautiful Beach Bound And Centrally Located San Diego Home.
How far in advance should I book my Serra Mesa holiday?
It's difficult to pick the best time for airfares, but we normally say the earlier, the better. Most international flights on Expedia become available up to 12 months in advance. If you're booking late, fear not. Budget prices appear from time to time just weeks before departure dates.
What does an Expedia Serra Mesa travel package include?
From flights and hotels to rental cars, Expedia can help you craft a Serra Mesa package that's perfect for you. Holidaying for a few weeks? Consider a flight, hotel and rental car bundle. If your break is short, a flight and hotel deal could be what you're after. Experiences can also be added once you've made your booking. Our travel packages make it a cinch to plan and save.
What should I know before booking a Serra Mesa travel package?
You can save a tidy sum by combining your hotels, airfares and rental cars. Once you've made your booking, you can add on things like day tours or experiences. Your next unforgettable holiday is only a few clicks away.
Can I choose my airline with a Serra Mesa Expedia holiday package?
With a holiday package, you're the one in charge. Whether you'd like to fly to Serra Mesa in economy or first class, simply choose from the available airline options. Expedia has access to over 550 partner airlines all over the world.
If I'm not able to travel, can I cancel my Serra Mesa holiday package?
Plans can change in the blink of an eye, so yes. You may be able to cancel or alter your Serra Mesa holiday package at no cost if you've booked in the last 24 hours. For bookings made more than 24 hours ago, you can still make the necessary changes, but your car rental company, hotel or airline may impose a charge. Want more information? Check out our Customer Service Portal. We'll help make sure your getaway goes off without a hitch.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

4.5/5(47 reviews)

Why not visit the animals who live at San Diego Zoo and see why this is a popular attraction in San Diego? Stroll along the area's seaside or experience its acclaimed theatre scene.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4/5(18 reviews)

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's fascinating museums and acclaimed art galleries.

San Diego Convention Center
Mission Bay featuring a beach

Mission Bay

4.5/5(31 reviews)

Explore the great outdoors at Mission Bay, a popular spot to commune with nature in San Diego. Stroll along the seaside in this family-friendly area or visit its top-notch restaurants.

Mission Bay