Compare and book 4 Star hotels in Big Pine Key, Florida

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Check availability on Big Pine Key 4 Star Hotels

Top Big Pine Key 4 Star Hotels

Our top choices for Big Pine Key 4-star hotels

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
2 outdoor pools, pool umbrellas, pool loungers

Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton

4.0 star property
8.8 out of 10, Excellent, (1286)
"Great stay "
The price is 4.223.810 ₫
5.787.165 ₫ total
includes taxes & fees
25 Aug - 26 Aug
Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
Tranquility Bay Beachfront Hotel and Resort
Terrace/patio

Tranquility Bay Beachfront Hotel and Resort

4.0 star property
8.8 out of 10, Excellent, (1000)
"Excellent stay. "
The price is 5.895.981 ₫
8.326.183 ₫ total
includes taxes & fees
9 Sept - 10 Sept
Tranquility Bay Beachfront Hotel and Resort
The Reef at Marathon, Florida Keys
Deluxe Villa | Private kitchen | Full-sized fridge, microwave, oven, stovetop

The Reef at Marathon, Florida Keys

4.0 star property
9.4 out of 10, Exceptional, (8)
"It’s always been my favorite. The villas fit all my needs. Fantastic location and friendly staff."
The Reef at Marathon, Florida Keys
Marlin Bay Resort & Marina
Property entrance

Marlin Bay Resort & Marina

4.5 star property
Marlin Bay Resort & Marina
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Villa, 3 Bedrooms | Balcony

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

4.0 star property
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Indigo Reef Marina Homes by Pack and Relax
Villa, 3 Bedrooms | Pool | Outdoor pool

Indigo Reef Marina Homes by Pack and Relax

4.0 star property
Indigo Reef Marina Homes by Pack and Relax
Indigo Reef Marina Pet Friendly Homes by Pack and Relax
Villa, 3 Bedrooms | Pool | Outdoor pool

Indigo Reef Marina Pet Friendly Homes by Pack and Relax

4.0 star property
Indigo Reef Marina Pet Friendly Homes by Pack and Relax
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard, MM 47, Marathon, FL
The price is 6.128.665 ₫ per night from 7 Sept to 8 Sept
6.128.665 ₫
8.462.014 ₫ total
7 Sept - 8 Sept
includes taxes & fees
9/10 Wonderful! (1,030 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colourful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key
Big Pine Key showing a bay or harbour, a coastal town and general coastal views

Top Big Pine Key Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?
Create unforgettable holiday memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. A favourite with our guests, this 4-star hotel offers loads of conveniences for a relaxing and comfortable stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To find a 4-star hotel in Big Pine Key that fits your budget, use Expedia's handy filters. Take a look at the available options during your holiday dates and use our pricing filter to set your limit. You can also list your results by the most budget-friendly stay first.

  • Search for the lowest price from 6.128.665 ₫

What's the difference between 5-star and 4-star hotels in Big Pine Key?
Treat yourself to luxury living during your Big Pine Key getaway by checking in to a 4-star hotel. As well as featuring upscale accommodation, these retreats are usually packed with amenities like large beds, complimentary bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour concierge assistance, elegant furnishings and world-class dining are only the start of the exclusive services and conveniences you'll likely have access to.