A river, a highway, and a dense forest.

Compare and book 4 Star hotels in Picayune, Mississippi

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Picayune 4 Star Hotels

Tonight
26 Sep - 27 Sep
Tomorrow
27 Sep - 28 Sep
Next weekend
2 Oct - 4 Oct
In two weeks
9 Oct - 11 Oct

Our top choices for Picayune 4-star hotels

A modern hotel lobby with a reception desk, seating area, and a dining space.
A hotel room with two beds, a desk, a chair, a nightstand, and a kitchenette in the background.
A modern cafe with seating areas, a coffee press, and large windows.
A hotel with a brick facade, a gas station, and a covered parking area.

1. Holiday Inn Express Picayune-Stennis Space Center by IHG

Holiday Inn Express Picayune-Stennis Space Center by IHG
Picayune
United States
Ken
2.961.036 ₫
3.227.529 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express Picayune-Stennis Space Center by IHG
A hotel room with a large bed, a sitting area with a chair, a desk, a television, and a bathtub.
A gym with exercise equipment, a mirror, and a wall-mounted TV.
A reception desk at a Days Inn with a chandelier above and a patterned border on the wall.
A Days Inn with a blue roof, a covered entrance, and a row of rooms.

2. Days Inn by Wyndham Picayune

Days Inn by Wyndham Picayune
Picayune
United States
Perry
1.435.064 ₫
1.564.220 ₫ total
includes taxes & fees
29 Sept - 30 Sept
Days Inn by Wyndham Picayune
A hotel room with two beds, a nightstand, a lamp, and a large floral painting on the wall.
A Coca-Cola branded vending machine with a reward program sign, located next to a white brick wall.
A small breakfast area with a counter, a coffee machine, and a trash can.
A reception area with a counter, a ceiling fan, a wall-mounted air vent, and a framed welcome sign.

3. Super 8 by Wyndham Picayune

Super 8 by Wyndham Picayune
Picayune
United States
Christine
1.532.466 ₫
1.670.388 ₫ total
includes taxes & fees
30 Sept - 1 Oct
Super 8 by Wyndham Picayune
A brick building with a sign reading "VILLAGE INN".
A hotel room with a sofa, a dining table, chairs, a potted plant, and a painting on the wall.
A dining area with a table and chairs, a kitchen area with a counter, and a sign that reads "Free Breakfast."
A hotel room with a bed, a desk with a television, a lamp, and a coat rack.

4. Heritage Inn Picayune

Heritage Inn Picayune
Picayune
United States
Jamie
2.103.634 ₫
2.292.962 ₫ total
includes taxes & fees
27 Sept - 28 Sept
Heritage Inn Picayune
A brown leather sofa, an orange armchair, and a marble coffee table with a floral centerpiece in a room with large windows and a view of the outdoors.
A hotel room with two beds, a desk, a chair, and a bathroom with a mirror.
A reception area with a glass door, a desk with a computer, and a red carpet with a logo.
A hotel kitchen with a coffee station, a clock, and a dining area with chairs and a table.

5. Econo Lodge Picayune

Econo Lodge Picayune
Picayune
United States
Cindy
1.862.336 ₫
2.029.947 ₫ total
includes taxes & fees
26 Oct - 27 Oct
Econo Lodge Picayune
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Picayune

Stroll through Crosby Arboretum's 700 acres of native plants and winding trails, then cool off at Friendship Park's splash pad. Don't miss the chance to explore local history at the Picayune Railway Museum or catch a show at the historic Picayune on Stage theatre.

See all hotels in Picayune
A river, a highway, and a dense forest.

Top Picayune Hotel Reviews

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Picayune?
With Expedia's handy search filters, bagging a superb deal on a 4-star hotel in Picayune just got easier. Start by keying in your chosen travel dates and length of your trip. Then list the results by price and pick a hotel that best fits your budget and style.
  • Search for the lowest price from 5.700.651 ₫
What's the difference between 5-star and 4-star hotels in Picayune?
Treat yourself to refined living during your Picayune escape by staying at a 4-star hotel. As well as featuring upscale accommodation, these properties are usually packed with amenities, including bathrobes, large beds and more. A 5-star hotel will go the extra mile to make your trip an even more lavish and unforgettable one. Round-the-clock concierge assistance, elegant décor and gourmet dining are a few of the first-rate services and conveniences you'll likely be able to enjoy.
Does Picayune have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to search for your next escape in Picayune where just about everything is taken care of, from your accommodation to your meals, entertainment and activities. We can also help you find standard 4-star stays in and around this destination.

Explore a world of travel with Expedia