Photo by Margherita Sidoti

Compare and book 4 Star hotels in Syracuse, Sicily

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Syracuse 4 Star Hotels

Our top choices for Syracuse 4-star hotels

Front of property – evening/night
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel
4.0 star property
Ortigia
9.6 out of 10, Exceptional, (908)
"The breakfast was delicious, the staff impeccable and the room delightful. All in all an excellent stay which I would wholeheartedly recommend. "
United Kingdom
Sarah
Algila' Ortigia Charme Hotel
Outdoor pool
Mercure Siracusa Prometeo

Mercure Siracusa Prometeo

Mercure Siracusa Prometeo
4.0 star property
Neapolis
9.0 out of 10, Wonderful, (486)
" Wry welcoming place to stay "
United Kingdom
Keith
Mercure Siracusa Prometeo
Seasonal outdoor pool
Grand Hotel Villa Politi

Grand Hotel Villa Politi

Grand Hotel Villa Politi
4.0 star property
Grottasanta
8.6 out of 10, Excellent, (943)
"Wonderful hotel, nice area and great buffet breakfast"
United States
paula
The price is 2.899.285 ₫
3.305.209 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Grand Hotel Villa Politi
Garden
Eureka Palace Hotel Spa Resort

Eureka Palace Hotel Spa Resort

Eureka Palace Hotel Spa Resort
4.0 star property
Syracuse
8.0 out of 10, Very good, (324)
"It’s amazing if you have your own car and are able to move around. Breakfast is good, the rooms are a little old but they are comfortable and clean, the staff is very kind. I’ve stayed at this hotel for the last 4 or 5 summer vacations. It’s an amazing place to stay if you want to explore the area."
United States
Giovanni
Eureka Palace Hotel Spa Resort
Exterior detail
Hotel Parco delle Fontane

Hotel Parco delle Fontane

Hotel Parco delle Fontane
4.0 star property
Tiche
9.2 out of 10, Wonderful, (281)
"Pool was excellent and the surrounding gardens superb "
United States
ROBERT
The price is 2.276.528 ₫
2.595.382 ₫ total
includes taxes & fees
14 Jan - 15 Jan 2026
Hotel Parco delle Fontane
Pool
UNA HOTELS One Siracusa

UNA HOTELS One Siracusa

UNA HOTELS One Siracusa
4.0 star property
Grottasanta
8.6 out of 10, Excellent, (540)
"Very nice hotel, nice sized rooms, great staff that was very helpful."
United States
Mark
The price is 3.625.582 ₫
4.133.135 ₫ total
includes taxes & fees
21 Dec - 22 Dec
UNA HOTELS One Siracusa
Reception
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection
4.0 star property
Ortigia
9.4 out of 10, Exceptional, (659)
"Great hotel"
United States
Caterina
The price is 4.743.891 ₫
5.527.438 ₫ total
includes taxes & fees
19 Dec - 20 Dec
Palazzo Artemide - VRetreats, SLH Collection
Aerial view
Grande Albergo Alfeo

Grande Albergo Alfeo

Grande Albergo Alfeo
4.0 star property
Santa Lucia
8.6 out of 10, Excellent, (651)
"The room was nice the location convenient. No view to speak of but centrally located"
Canada
Eric
Grande Albergo Alfeo
Suite | Soundproofing, free WiFi
Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri

Hotel Palazzo Cavalieri
4.0 star property
Santa Lucia
8.8 out of 10, Excellent, (39)
"The location of this hotel is ideal! Directly between the train station and Ortigia. Easy walking to many different restaurants. We very much enjoyed our short stay here and the daily activities hosted by the Hotel. My only iffy thing was the tiles in the bathroom (the shower specifically) seemed a bit older and maybe not as cleanly as it could be, but all in all the room was quite nice. "
Canada
Lindsay
The price is 3.123.903 ₫
3.561.193 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
Hotel Palazzo Cavalieri
Classic Double Room, Partial Sea View | View from room
Charme Hotel Henry's House

Charme Hotel Henry's House

Charme Hotel Henry's House
4.0 star property
Ortigia
9.6 out of 10, Exceptional, (322)
"Great location. Very friendly and helpful staff. Nice breakfast."
United States
Alan
The price is 7.457.907 ₫
8.512.856 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Charme Hotel Henry's House
Outdoor pool, pool loungers
Hotel Villamare

Hotel Villamare

Hotel Villamare
4.0 star property
Syracuse
9.2 out of 10, Wonderful, (109)
"All staff were very professional and friendly, took time to understand our needs. Breakfast was excellent, good range. Evening meals good but limited menu. Good location near a very nice beach and easy to get around by car"
United Kingdom
Colin
Hotel Villamare
Seasonal outdoor pool
Hotel Relax

Hotel Relax

Hotel Relax
4.0 star property
Epipoli
8.2 out of 10, Very good, (33)
"Camera spaziosa e pulita, dintorni silenziosi, personale molto attento agli ospiti, gentile e cordiale, colazione a buffet con molte opzioni abbondanti, puntuali."
Italy
Gabriella
The price is 2.529.476 ₫
2.883.519 ₫ total
includes taxes & fees
17 Jan - 18 Jan 2026
Hotel Relax
2 bars/lounges
Aretusa Palace Hotel

Aretusa Palace Hotel

Aretusa Palace Hotel
4.0 star property
Syracuse
6.8 out of 10, (98)
"Ruggine sui tetti del bagno. "
Italy
Vincenzo
Aretusa Palace Hotel
Interior
Dolce by Wyndham Siracusa I Monasteri Golf & Spa

Dolce by Wyndham Siracusa I Monasteri Golf & Spa

Dolce by Wyndham Siracusa I Monasteri Golf & Spa
4.0 star property
Syracuse
7.2 out of 10, Good, (32)
"Great upgrade Wonderful place "
United States
Veronique
The price is 3.035.371 ₫
3.460.407 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Dolce by Wyndham Siracusa I Monasteri Golf & Spa
Reception
Hotel Centrale

Hotel Centrale

Hotel Centrale
4.0 star property
Syracuse
7.2 out of 10, Good, (92)
"Close to station and Ortigia -clean and helpful - great staging post."
United Kingdom
Philippa
The price is 8.210.860 ₫
9.360.294 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Hotel Centrale
Courtyard
Borgo Pantano

Borgo Pantano

Borgo Pantano
4.0 star property
Syracuse
9.8 out of 10, Exceptional, (276)
"Beautiful property and excellent breakfast. Lived our stay! "
United States
Feldman
Borgo Pantano
2 outdoor pools, pool umbrellas, pool loungers
VOI Arenella Resort

VOI Arenella Resort

VOI Arenella Resort
4.0 star property
Syracuse
8.0 out of 10, Very good, (130)
"Loved area"
United States
Frank
VOI Arenella Resort
Terrace/patio
Villa Fanusa

Villa Fanusa

Villa Fanusa
4.0 star property
Syracuse
8.4 out of 10, Very good, (44)
"The hotel is located in the countryside so is a bit remote. There are buses but having a car is better. We visited out of high season and had the pool to ourselves every day. We loved that."
United Kingdom
J
Villa Fanusa
Lobby
Il Podere Hotel Restaurant

Il Podere Hotel Restaurant

Il Podere Hotel Restaurant
4.0 star property
Syracuse
8.4 out of 10, Very good, (118)
"Staff was very friendly and kind. The rooms are large with enough space for our lugage. We had our own terrasse. The pool was great. "
United States
Tania
Il Podere Hotel Restaurant
Seasonal outdoor pool, open 10:00 AM to 6:00 PM, pool loungers
Life Hotels Kalaonda Resort

Life Hotels Kalaonda Resort

Life Hotels Kalaonda Resort
4.0 star property
Syracuse
8.6 out of 10, Excellent, (109)
"Lovely place!"
Canada
Hyun Jin
Life Hotels Kalaonda Resort
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Syracuse.
Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection

Via Riva Nazario Sauro Syracuse SR
The price is 5.823.134 ₫ per night from 12 Jan to 13 Jan
5.823.134 ₫
6.714.606 ₫ total
12 Jan - 13 Jan 2026
includes taxes & fees
9.2/10 Wonderful! (250 reviews)
Still don't see what you're looking for?
See all properties in Syracuse.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe

Top Syracuse Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Syracuse?
Kick back in 4-star hotel comfort at Algila Ortigia Charme Hotel. Rated highly by many of our guests, it offers concierge services and room service. Also check out Hotel Roma. Limousine services and premium bedding help make this getaway another leading pick in Syracuse.
How much does it cost to stay in a 4-star hotel in Syracuse?
To lock in a 4-star hotel in Syracuse that's within your budget, make use of Expedia's search and sort filters. Check out the availability during your chosen dates and use our pricing filter to set your limit. You can also list your results by the cheapest retreat first.

  • Search for the lowest price from 4.173.635 ₫

What's the difference between 5-star and 4-star hotels in Syracuse?
Offering a welcoming guest experience and upmarket décor, 4-star hotels are an excellent option for your Syracuse escape. These kinds of accommodation generally come with loads of handy amenities that make it simple to unpack and relax — think complimentary bathrobes, gyms and pools. Or live in the lap of luxury at a 5-star hotel designed to pamper with luxury perks and amenities. On-site health clubs, premium toiletries and fine dining are typically featured at these plush properties.