Cape Girardeau County Holidays

Book a Hotel + Flight or Car together to unlock savings

Photo by Jessica King

Top hotels in Cape Girardeau County

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.367.367 ₫ per night from 21 Dec to 22 Dec
2.367.367 ₫
2.670.424 ₫ total
21 Dec - 22 Dec
includes taxes & fees
9.4/10 Exceptional! (1,004 reviews)
Beds were great. Very clean all around. Very nice breakfast with glutten free bread for my wife.

Reviewed on 8 Dec 2025

Drury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is 2.533.364 ₫ per night from 18 Dec to 19 Dec
2.533.364 ₫
2.857.989 ₫ total
18 Dec - 19 Dec
includes taxes & fees
9.2/10 Wonderful! (470 reviews)
Didn’t eat breakfast

Reviewed on 11 Dec 2025

The Riverview
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3 out of 5
3003 SOUTH OLD ORCHARD ROAD Jackson MO
Fully refundableReserve now, pay when you stay
The price is 2.214.155 ₫ per night from 7 Jan to 8 Jan
2.214.155 ₫
2.396.269 ₫ total
7 Jan - 8 Jan 2026
includes taxes & fees
8.8/10 Excellent! (663 reviews)
Was a great stay. Room walls could have been a bit cleaner but nothing to worry about in the end. Will be staying again. Staff was amazing, bathroom was clean, breakfast was good.

Reviewed on 6 Dec 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
See all 249 properties in Cape Girardeau County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Cape Girardeau County holiday package cost?
Perhaps less than you imagined — from a tempting , actually! By bundling hotels, flights and car rentals into your own customized travel package, your trip to Cape Girardeau County is just a few clicks away.
How do I get a cheap travel package to Cape Girardeau County?
Creating your own Cape Girardeau County holiday package with Expedia is one of the easiest ways to save. We have access to more than 550 air carriers and 1null000null000 properties spread across the globe. With such an awesome range to select from, you'll have no trouble creating your ideal trip.
What are the top hotels in Cape Girardeau County?
For hotels in Cape Girardeau with cosy beds and friendly service, you can't go past Drury Plaza Hotel Cape Girardeau Conference Centre and Pear Tree Inn Cape Girardeau West. If you're swinging by Jackson as well, you can look forward to a relaxing night's sleep at Holiday Inn Express Hotel & Suites Cape Girardeau I-55null an IHG Hotel or Auburn Place Hotel And Suites.
How far in advance should I book my Cape Girardeau County holiday?
Reserving your spot early with Expedia means one less thing to worry about. Most carriers advertise tickets up to 12 months in advance. Generally, this is the cheapest time to book. If circumstances have left you booking late, discount tickets to Cape Girardeau County sometimes occur in the weeks leading up to departure.
What does an Expedia Cape Girardeau County travel package include?
Choose from a combination of rental cars, hotels and flights. Once you've made your booking, you can add activities and tours. Want to pick your fare class? That's also possible. The choice is all yours when it comes to planning your perfect Cape Girardeau County getaway.
What should I know before booking a Cape Girardeau County travel package?
You'll save plenty with an Expedia travel package. Combine your flights, rental cars and hotels and land exciting discounts. Hotels aren't your only option, though. We have oceanfront condos, city apartments and everything in between!
Can I choose my airline with a Cape Girardeau County Expedia holiday package?
Definitely. Expedia has more than 550 airline partners to choose from around the world. With so much choice, finding the right carrier to bring you to Cape Girardeau County will be a breeze.
If I'm not able to travel, can I cancel my Cape Girardeau County holiday package?
Yes, you can. We realise life happens, so we're here to help if you have to make changes to your Cape Girardeau County holiday package. You may be able to cancel or amend your itinerary for free if you've booked in the last 24 hours. Your airline, hotel or car rental company may charge you a fee if you booked more than 24 hours ago. Take a look at our Customer Service Portal for more information. Also, check your itinerary for the finer details on change fees.