Find hotels in Center, MO from 1.311.975 ₫

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Go beyond your typical stay in Center

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Pool
Pool
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Pet friendly
Pet friendly

Check prices for these dates

Tonight
5 Nov - 6 Nov
Tomorrow
6 Nov - 7 Nov
This weekend
6 Nov - 8 Nov
Next weekend
13 Nov - 15 Nov

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Our top choices for Center hotels

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

1. Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
Hannibal
9.6 out of 10, Exceptional, (1,000 reviews)
"Great stay- within walking distance of good restaurant and coffee shop. Breakfast included hot items with adequate seating."
United States
ELAINE
The price is 2.820.746 ₫
3.281.939 ₫ total
includes taxes & fees
6 Dec - 7 Dec
Sleep Inn & Suites Hannibal West
A hotel room with a bed, a sofa, a desk, and a lamp.

2. Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
Hannibal
7.6 out of 10, Good, (772 reviews)
"Front desk helpful Clean rooms Great breakfast and lady fixing our breakfast was helpful and kept plenty of food ready for all"
United States
Jerry
The price is 1.917.027 ₫
2.288.466 ₫ total
includes taxes & fees
25 Nov - 26 Nov
Comfort Inn & Suites - Hannibal
A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

3. Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
Hannibal
8.0 out of 10, Very good, (1,002 reviews)
"Our go to hotel for years when we visit Hannibal."
United States
Gayle
The price is 1.830.334 ₫
2.129.592 ₫ total
includes taxes & fees
25 Nov - 26 Nov
Quality Inn & Suites Hannibal West
A park with a pond, picnic tables, and a gazebo.

4. Cannon Dam Cabins

Cannon Dam Cabins
3.0 star property
Perry
9.4 out of 10, Exceptional, (26 reviews)
"Amazing place to stay! You can’t beat the indoor pool whether it is storming or feels like the fires from hell are raining on earth you can still enjoy a great swim without worrying about lightning or burning to death. The people are incredibly kind and on top of anything you may need and the cabins are a perfect relaxing get away with nice a/c and plenty of sleeping space! Thank you for another amazing stay!"
United States
Erika
The price is 2.641.958 ₫
2.810.383 ₫ total
includes taxes & fees
17 Nov - 18 Nov
Cannon Dam Cabins
A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

5. Best Western On The River

Best Western On The River
2.5 star property
Hannibal
8.8 out of 10, Excellent, (1,002 reviews)
"Location was great!"
United States
Rob
The price is 2.597.968 ₫
2.996.706 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Best Western On The River
A hotel room with two beds, a nightstand, and a lamp.

6. The Junction Inn

The Junction Inn
2.0 star property
Perry
6.4 out of 10, (48 reviews)
"good beds nice people good if your fishing Mark Twain"
United States
PAUL
The price is 1.719.073 ₫
1.828.664 ₫ total
includes taxes & fees
5 Dec - 6 Dec
The Junction Inn
A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

7. Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
Hannibal
7.2 out of 10, Good, (1,004 reviews)
"Clean, safe hotel and friendly staff"
United States
Julie
The price is 1.504.912 ₫
1.735.917 ₫ total
includes taxes & fees
3 Dec - 4 Dec
Super 8 by Wyndham Hannibal
A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

8. Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
Hannibal
7.4 out of 10, Good, (1,000 reviews)
"Excellent place to stay"
United States
Jared
The price is 1.491.793 ₫
1.720.746 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Motel 6 Hannibal, MO
An indoor swimming pool with a tiled ceiling, multiple levels with windows, and seating areas around the pool.

9. Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
Hannibal
6.4 out of 10, (830 reviews)
"Thanks for the hospitality. We enjoyed this stay very clean."
United States
Natasha
The price is 1.311.975 ₫
1.523.531 ₫ total
includes taxes & fees
1 Dec - 2 Dec
Baymont by Wyndham Hannibal
A living room with a sofa, coffee table, and patterned rug. There are large windows with blinds, a chandelier, and a view of the outside.

10. FairBridge Inn Express, Monroe City

FairBridge Inn Express, Monroe City
2.0 star property
Monroe City
8.4 out of 10, Very good, (495 reviews)
"Nice place to stop for a one night stay."
United States
Ron
The price is 2.315.250 ₫
2.514.362 ₫ total
includes taxes & fees
19 Nov - 20 Nov
FairBridge Inn Express, Monroe City
A hotel room with two beds, a wooden headboard, a nightstand with a phone, and a wall-mounted lamp.

11. Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
Hannibal
7.4 out of 10, Good, (296 reviews)
"Pretty good place to stay at with a great price !!"
United States
Christian
The price is 1.800.750 ₫
2.077.294 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Days Inn by Wyndham Hannibal
A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.

12. Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
Hannibal
7.4 out of 10, Good, (188 reviews)
"Great price! Nice comfortable clean room"
United States
Debbie
The price is 1.504.913 ₫
1.747.581 ₫ total
includes taxes & fees
1 Dec - 2 Dec
Howard Johnson BY Wyndham Hannibal
A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

13. Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
Hannibal
8.8 out of 10, Excellent, (47 reviews)
"The room was very clean. It had a hot tub in it and it was also very clean and worked properly. We enjoyed our stay there."
United States
Connie
The price is 4.104.241 ₫
5.625.735 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Lighthouse Inn & Suites
A view from a window overlooking a grassy area with a body of water and a distant shoreline.

14. Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
Hannibal
9.6 out of 10, Exceptional, (204 reviews)
"Very nice room and great view of the river. Very comfortable bed and very nice shower. Walking distance to so many restaurants and shops. We enjoyed our stay very much!"
United States
Christina
The price is 3.901.281 ₫
5.390.342 ₫ total
includes taxes & fees
8 Nov - 9 Nov
Riverside Inn Hannibal
A wooden staircase with a handrail, a small table with a lamp, and a chair in a room with a door and windows.

15. Garden House Bed and Breakfast

Garden House Bed and Breakfast
3.0 star property
Hannibal
8.4 out of 10, Very good, (57 reviews)
"Beautiful Queen Ann B&B, was reasonably priced and within walking distance to the river and down town Hannibal attractions."
United States
Debbie
The price is 2.479.599 ₫
2.860.216 ₫ total
includes taxes & fees
6 Nov - 7 Nov
Garden House Bed and Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Center Hotel Reviews

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.
Best Western On The River

Best Western On The River

Best Western On The River
Hannibal

10/10 Excellent

Very nice one night stay here
United Kingdom
Wendy
Reviewed June 30, 2026
Best Western On The River

Frequently Asked Questions

What's the seasonal weather in Center?

The hottest months are usually July and August, with an average temperature of 23°C, while the coldest months are January and February, with an average of 2°C. Average annual precipitation for Center is 1199 mm.