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Our top choices for Daphne hotels with a spa

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Comfort Suites Mobile-South Alabama University Area

Comfort Suites Mobile-South Alabama University Area

2.5 star property
Dauphin Acres
7.8 out of 10, Good, (1000)
"Staff was friendly Hotel was very nice Breakfast was ok"
United States
Lisa - Jason
The price is 1.994.285 ₫
2.333.313 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Comfort Suites Mobile-South Alabama University Area
2 bars/lounges, poolside bar
The Battle House Renaissance Mobile Hotel & Spa

The Battle House Renaissance Mobile Hotel & Spa

4.0 star property
Mobile Central Business District
9.2 out of 10, Wonderful, (1000)
"Beautiful place great staff"
United States
stephen
The price is 4.903.332 ₫
5.761.415 ₫ total
includes taxes & fees
17 Dec - 18 Dec
The Battle House Renaissance Mobile Hotel & Spa
Sauna, hot tub, steam room, body treatments, aromatherapy, body wraps
Grand Hotel Golf Resort & Spa, Autograph Collection

Grand Hotel Golf Resort & Spa, Autograph Collection

4.0 star property
Fairhope
9.6 out of 10, Exceptional, (639)
"Great facility, grounds, and things to do."
United States
Laurence
The price is 8.936.718 ₫
11.305.080 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Grand Hotel Golf Resort & Spa, Autograph Collection
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

Looking for a spa hotel in Daphne?
Soothe the senses with some time in one of our wonderful spa hotels. Travellers recommend the popular shops and gourmet restaurants in Daphne. Enjoy the entertainment choices and beaches during your holiday. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your stay.
What's there to see and do in Daphne?
Experience Daphne with a stop at Daphne Civic Center, Daphne Sports Complex and Daphne Bayfront Park. If you have spare time during your trip, you might want to make a stop at Mobile Bay and De-Cuba.
What is a Daphne spa hotel?
Spa hotels in Daphne provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.