A blue kayak on calm river water with trees and rocky cliffs in the background.

Find hotels in De Soto, MO from 1.612.141 ₫

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Filter by

Star rating

Guest rating

Our top choices for De Soto hotels

A modern kitchen with a central island, built-in appliances, and a view into the dining area.
A reception desk with a modern design, a digital screen, and a sign indicating 'IHG' branding.
A hotel room with a bed, a desk, a microwave, a coffee maker, and a TV mounted on the wall.
A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

1. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Festus
United States
Terry
2.254.692 ₫
2.578.240 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
A hotel lobby with a reception desk, two red armchairs, a floral centerpiece, a framed cityscape picture, and a dining area in the background.
A hotel lobby with a reception desk, two red armchairs, a coffee table, a floral centerpiece, and a dining area with wooden tables and chairs.
A hotel room with a living area, kitchenette, and a desk with a computer and chair.
A hotel room with a shower, a bathtub, a toilet, a bed, a desk, a chair, and a television.

2. Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
Festus
United States
Michelle
1.845.219 ₫
2.156.138 ₫ total
includes taxes & fees
4 Nov - 5 Nov
Comfort Inn Festus - St Louis South
A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.

3. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
United States
Abram
2.317.802 ₫
2.650.407 ₫ total
includes taxes & fees
29 Oct - 30 Oct
Hampton Inn & Suites By Hilton Festus
A modern lobby with seating areas, a patterned carpet, and a cityscape mural on the wall.
A hotel room with a large bed, a bedside table with a lamp, a vanity with a mirror, and a wall with framed pictures.
A spacious lobby with a modern design, featuring a large seating area with purple and gray chairs, a patterned carpet, and a cityscape mural on the wall.
A swimming pool with lounge chairs and a view of the night sky.

4. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
Festus
United States
Debra S
2.180.831 ₫
2.493.780 ₫ total
includes taxes & fees
1 Nov - 2 Nov
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
A hotel room with a large bed, a desk with a lamp, a television, and a bathroom visible in the background.
A corridor with a wooden floor, beige walls, and a painting on the left.
A multi-story hotel with a brick facade and large windows, featuring a parking lot in front.
An indoor swimming pool with a tiled edge, surrounded by lounge chairs and a potted plant.

5. Baymont by Wyndham Festus

Baymont by Wyndham Festus
Festus
United States
Gretchen
1.586.059 ₫
1.813.658 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Baymont by Wyndham Festus
A lobby with a reception desk, blue sofas, a coffee table, and a plant display.
A hotel room with a desk, two beds, a television, a lamp, and a cityscape painting on the wall.
A hotel room with a TV, a sofa, a small table, a lamp, and a carpeted floor.
A spacious dining area with multiple tables and chairs, large windows, and ceiling lights.

6. Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold
Arnold
United States
Bailey
3.265.157 ₫
3.774.521 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Drury Inn & Suites St. Louis Arnold
A hotel lobby with a reception desk, a revolving door, seating area with sofas, and a patterned rug.
A corridor with a wooden floor, beige walls, and a painting on the left.
A hotel room with two beds, a nightstand, a lamp, and a painting on the wall.
A hotel with a brick facade, multiple windows, and a parking lot.

7. Days Inn & Suites By Wyndham Festus

Days Inn & Suites By Wyndham Festus
Festus
United States
Larry
1.983.798 ₫
2.268.472 ₫ total
includes taxes & fees
15 Oct - 16 Oct
Days Inn & Suites By Wyndham Festus
A modern interior with a high ceiling, large windows, and a brick wall. There are orange chairs and a green sofa with orange cushions.
A modern building with a prominent entrance, large windows, and a covered parking area.
A modern indoor space with a large window, a seating area with sofas and chairs, and a dining area with tables and chairs.
A lobby with a reception desk, seating area, and large windows.

8. Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold
Arnold
United States
Lynda
2.332.181 ₫
2.696.002 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Pear Tree Inn St. Louis Arnold
A bedroom with a bed, a wooden headboard, a window with a view of greenery, and a tray with breakfast items.
A rustic cabin with a wooden exterior, a small deck, and a picnic table.
A cabin with two Adirondack chairs outside, a picnic table, and a small black structure with a window and a sign.
Property amenity

9. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village
United States
cynthia
2.619.132 ₫
4.153.684 ₫ total
includes taxes & fees
12 Nov - 13 Nov
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.
A modern bathroom with a bathtub, a window with curtains, and a view of a green landscape.
A spacious hotel lobby with a dining area, kitchen, and large windows.
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

10. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
Farmington
United States
CURTIS
2.623.022 ₫
2.999.426 ₫ total
includes taxes & fees
25 Oct - 26 Oct
Crown Pointe Lodge, BW Signature Collection
Room
Exterior
Property amenity
Pool

11. Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely
Pevely
United States
Steve
1.586.059 ₫
1.821.588 ₫ total
includes taxes & fees
25 Oct - 26 Oct
Super 8 by Wyndham Pevely
A hotel room with a bed, a sofa, a desk, and a chair.
A hotel lobby with a central reception desk, multiple seating areas, and a tiled floor.
A coffee station with two coffee machines, a coffee press, and various coffee-related items on a wooden counter.
A modern living room with a sofa, armchairs, a coffee table, and a painting on the wall.

12. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
Farmington
United States
Sheila
3.059.976 ₫
3.499.082 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Holiday Inn Express & Suites Farmington by IHG
An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.
A hotel room with two beds, a flat-screen TV, a desk, and a window with blinds.
A hotel room with a wooden desk, a chair, a television, a microwave, and a minibar.
A modern hotel lobby with multiple seating areas, a large flat-screen TV mounted on the wall, and a visible exit sign.

13. Hampton Inn Farmington

Hampton Inn Farmington
Farmington
United States
Charlie
2.511.260 ₫
2.871.627 ₫ total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn Farmington
A stone building with a white porch and a small garden with yellow flowers.
A cozy seating area with wicker chairs and a coffee table, a brick wall, and a window with a view of greenery.
A vintage upright piano with a mirror above it, a lamp, and a floral wallpaper pattern.
A dining room with a long table set for a meal, surrounded by chairs with lace covers. A piano and a bookshelf are visible in the background.

14. Corner George Inn Bed & Breakfast

Corner George Inn Bed & Breakfast
Maeystown
United States
Mark
3.333.316 ₫
3.699.314 ₫ total
includes taxes & fees
14 Nov - 15 Nov
Corner George Inn Bed & Breakfast
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.
A hotel room with a large bed, two sofas, a desk with a lamp, a microwave, and a TV.
A parking lot with a tree in bloom, a red fire hydrant, and a building in the background.
A gym with cardio equipment, a bench press, and a squat rack.

15. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
Farmington
United States
stewart
1.409.830 ₫
1.612.141 ₫ total
includes taxes & fees
11 Nov - 12 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A modern hotel room with a large bed, a desk with a lamp, a TV, and a wardrobe.
A reception area with a large number '6' sign, a modern counter, and a colorful striped wall.
A motel with a prominent '6' sign, a well-lit entrance, and a visible parking area.
A modern kitchen with a black microwave, a refrigerator, and a flat-screen TV mounted above a desk with a yellow lamp.

16. Motel 6 Bonne Terre, MO

Motel 6 Bonne Terre, MO
Bonne Terre
United States
Kathleen
1.590.751 ₫
1.877.019 ₫ total
includes taxes & fees
13 Nov - 14 Nov
Motel 6 Bonne Terre, MO
A wooden deck with two Adirondack chairs and a hammock.
A spacious living room with a wooden ceiling, a fireplace, and a television.
A bedroom with a large bed, wooden ceiling, and a view of the outdoors.
A spacious living room with wooden floors, a stone fireplace, and a mounted television.

17. Tiny Houses of French Village

Tiny Houses of French Village
French Village
United States
Chris
5.124.164 ₫
8.042.734 ₫ total
includes taxes & fees
15 Oct - 16 Oct
Tiny Houses of French Village
A large, two-story house with a wrap-around porch and a central tower.
A dining room with a wooden table set for four, surrounded by upholstered chairs. A large wooden cabinet with intricate carvings is positioned against the wall.
A room with a red velvet sofa, a chandelier, a mirror, and a vanity with a sink.
A four-poster canopy bed with a wooden headboard, a chandelier, and a radiator on the floor.

18. The Conner House B&B

The Conner House B&B
Prairie du Rocher
United States
James
4.049.375 ₫
4.493.997 ₫ total
includes taxes & fees
15 Oct - 16 Oct
The Conner House B&B
A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.
A modern waiting area with a grey sofa, a small table, and a black office chair. There are two doors with signs indicating restrooms.
An indoor swimming pool with clear lanes, a sunlit room with a view, and a staircase leading to an upper level.
A hotel reception area with a green carpet, a reception desk, a seating area with chairs, and a poster advertising the hotel.

19. Quality Inn Farmington

Quality Inn Farmington
Farmington
United States
Tracy
1.512.199 ₫
1.818.104 ₫ total
includes taxes & fees
12 Nov - 13 Nov
Quality Inn Farmington
A multi-story hotel with a prominent sign reading "Woodspring Suites".
A hallway with a reception desk, framed artwork on the walls, and a QR code on the floor.
A hotel room with a bed, a desk, a chair, a microwave, and a painting on the wall.
A person loading a washing machine with a basket of clothes.

20. WoodSpring Suites St. Louis Arnold

WoodSpring Suites St. Louis Arnold
Arnold
United States
Lori
2.203.961 ₫
2.547.779 ₫ total
includes taxes & fees
15 Oct - 16 Oct
WoodSpring Suites St. Louis Arnold
View all properties
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular De Soto attractions

Eastside Community Park

This area park offers a playground, basketball court, and shaded pavilion for family gatherings. Enjoy a picnic under mature trees or shoot hoops while children explore the age-appropriate play equipment.
See properties

Big Lake

Missouri's largest oxbow lake offers serene waters for boating and premier bird-watching. Explore the surrounding wetlands during spring migrations when hundreds of species make this natural haven their temporary home.
See properties

Sunrise Lake Beach

Why not spend a lazy afternoon at Sunrise Lake Beach during your trip to De Soto?
See properties

Sunrise Lake Park

Sunrise Lake Park offers serene fishing and kayaking on tranquil waters surrounded by Missouri's natural beauty. Pack a picnic lunch to enjoy lakeside views while watching for local wildlife.
See properties

Ritcher Park

After visiting Ritcher Park, make a plan to see the other sights and activities in De Soto.
See properties

Sunrise Lake

Commune with nature and explore the great outdoors at Sunrise Lake during your travels in De Soto.
See properties

Valle Lake Beach

Valle Lake Beach offers a private sanctuary for fishing and boating within De Soto's gated community. Residents and their guests enjoy the serene shoreline, perfect for picnics amid Missouri's natural beauty.
See properties

Joachim Park

This community park alongside Joachim Creek offers two full-size basketball courts in a serene natural setting. Enjoy a pickup game or relax by the water, with convenient off-street parking available.
See properties

Learn more about De Soto

Get away to De Soto! Enjoy the local cuisine and more.

See all hotels in De Soto
A blue kayak on calm river water with trees and rocky cliffs in the background.
Photo by Jessica King

Top De Soto Hotel Reviews

Quality Inn Farmington

Quality Inn Farmington

8/10 Good
"Staff clean room"
julie 1-night trip
Posted 1 day ago
Quality Inn Farmington
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

10/10 Excellent
"I think this hotel and staff are the best ive ever stayed at i will be back i was very well treated and it was a awsome stay"
Terry 2-night trip
Posted 1 day ago
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi

10/10 Excellent
"Great staff. Renovated rooms. Also complimentary breakfast."
Ryan 1-night trip
Posted 2 days ago
Super 8 by Wyndham Potosi
Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus

10/10 Excellent
"This is a very new and clean hotel. It just opened in July 2026. Everything felt fresh and clean."
Beverly 2-night trip
Posted 2 days ago
Hampton Inn & Suites By Hilton Festus
Days Inn & Suites By Wyndham Festus

Days Inn & Suites By Wyndham Festus

8/10 Good
"There was a nice vanity in the bathroom obviously bought at Hood's across the street. Then there was a round toilet seat on an extended toilet and a hole in the ceiling."
Larry 1-night trip
Posted 3 days ago
Days Inn & Suites By Wyndham Festus
Drury Inn & Suites St. Louis Arnold

Drury Inn & Suites St. Louis Arnold

8/10 Good
"When I walked in, my first thought was 'Icould have gotten this same room at Super 8.' It was.clean with no surprises, and the bathroom set it apart."
Larry 1-night trip
Posted 3 days ago
Drury Inn & Suites St. Louis Arnold
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"The room was clean and the staff was very helpful. A great getaway for anyone who likes nature"
Davonne 3-night trip
Posted 4 days ago
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

More cheap stays in De Soto

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO
1.409.830 ₫
1.612.141 ₫ total
11 Nov - 12 Nov
includes taxes & fees
8/10 Very good! (1,001 reviews)
Baymont Inn and Suites by Wyndham Farmington, MO
Super 8 by Wyndham Bonne Terre

Super 8 by Wyndham Bonne Terre

8 Northwood Drive Highway 67 A Bonne Terre MO
1.633.716 ₫
1.794.637 ₫ total
1 Nov - 2 Nov
includes taxes & fees
Super 8 by Wyndham Bonne Terre
Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO
1.845.219 ₫
2.156.138 ₫ total
4 Nov - 5 Nov
includes taxes & fees
Comfort Inn Festus - St Louis South
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

1802 Gamel Cemetery Road Festus MO
2.254.692 ₫
2.578.240 ₫ total
1 Nov - 2 Nov
includes taxes & fees
9.4/10 Exceptional! (784 reviews)
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Pear Tree Inn St. Louis Arnold

Pear Tree Inn St. Louis Arnold

1201 Drury Ln Arnold MO
2.332.181 ₫
2.696.002 ₫ total
18 Oct - 19 Oct
includes taxes & fees
Pear Tree Inn St. Louis Arnold
Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection

4245 Hunt Rd Farmington MO
2.623.022 ₫
2.999.426 ₫ total
25 Oct - 26 Oct
includes taxes & fees
8.8/10 Excellent! (693 reviews)
Crown Pointe Lodge, BW Signature Collection

Hotels in De Soto with star rating

Frequently asked questions

What's the seasonal weather like in De Soto?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 3°C. Average annual precipitation for De Soto is 1181 mm.

Explore a world of travel with Expedia