Grand Isle Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Grand Isle

Find the best Grand Isle areas and neighborhoods for the activities you enjoy most. Learn more about Grand Isle
An aerial view of a town with a mix of commercial and residential buildings, a large parking lot, and a body of water.

Downtown Port St. Joe

If you're spending some time in Downtown Port St. Joe, Port Saint Joe City Hall and Port St. Joe Marina are top sights worth seeing.

Find hotels in Downtown Port St. Joe

Top hotels in Grand Isle

Days Inn by Wyndham Panama City/Callaway

Days Inn by Wyndham Panama City/Callaway

2 out of 5
435 North Tyndall Parkway Panama City FL
Fully refundableReserve now, pay when you stay
The price is 1.722.906 ₫ per night from 13 Aug to 14 Aug
1.722.906 ₫
1.861.945 ₫ total
13 Aug - 14 Aug
includes taxes & fees
Days Inn by Wyndham Panama City/Callaway
Driftwood Inn

Driftwood Inn

2 out of 5
2105 U.S. 98 Mexico Beach FL
Fully refundableReserve now, pay when you stay
The price is 7.113.798 ₫ per night from 2 Aug to 3 Aug
7.113.798 ₫
7.967.222 ₫ total
2 Aug - 3 Aug
includes taxes & fees
9.6/10 Exceptional! (84 reviews)
"Lots of character and charm. Enjoyed all the different bird houses and water fountains. Quick and easy access to the beach. Will be back!"

Reviewed on 26 Jul 2026

Driftwood Inn
MainStay Suites Port Saint Joe South

MainStay Suites Port Saint Joe South

2.5 out of 5
3951 E Highway 98 Port St. Joe FL
Fully refundableReserve now, pay when you stay
The price is 3.689.835 ₫ per night from 17 Aug to 18 Aug
3.689.835 ₫
4.132.615 ₫ total
17 Aug - 18 Aug
includes taxes & fees
8.6/10 Excellent! (749 reviews)
"We stayed here prior to our week in a house on Cape San Blas. Great stay! With full refrigerator/freezer, we were able to unload our ice chest to keep food items cold or frozen until we could check-in to the beach house. Location is good - close to hospital - a few miles from Port St. Joe. Quiet ..."

Reviewed on 25 Jul 2026

MainStay Suites Port Saint Joe South
See all 2,287 properties in Grand Isle
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Grand Isle holiday package cost?
We make it simple to travel the world, with Grand Isle packages starting from just . You'll have the flexibility to bundle your preferred airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Grand Isle?
Booking a Grand Isle holiday package with Expedia is one of the easiest ways to save. We offer more than 550 air carriers and 1null000null000 properties throughout the world. With such a broad range to select from, you'll have no worries putting together your perfect adventure.
Where should I stay in Grand Isle?
If you're interested in visiting Mexico Beach, save yourself the stress of commuting and book a hotel nearby. It's one of the top attractions in this neighbourhood.
What are the top hotels in Grand Isle?
Beautiful Fully Remodeled Home With Private Pool is one of Grand Isle's most sought-after properties. Secure a room here and you can snooze soundly knowing you're in capable hands.
How far in advance should I book my Grand Isle holiday?
It's always wise to book early. Air carriers generally advertise flight tickets around a year prior to departure, and this is an excellent opportunity to pick up some of the cheapest prices. Boss just told you to take some holiday time next month? No problem! Expedia are never short of fantastic bargains to send you off on the getaway of your dreams, at an affordable price.
What does an Expedia Grand Isle travel package include?
Flights, hotels and a reliable car for all your road trip adventures. Simply select your favourite bundle and gain access to great discounts. Once you've made your booking, add on some experiences and tours and watch your savings pile up. When it comes to crafting your Grand Isle holiday, you're in charge!
What should I know before booking a Grand Isle travel package?
A travel package can be tailored to your budget and is a great way to make your hard-earned dollars stretch further. How little or much you include is up to you. Rental cars, hotels and flights — mix and match whatever combination works with your plans.
Can I choose my airline with a Grand Isle Expedia holiday package?
With a holiday package, you're always in charge. Whether you're eager to fly to Grand Isle in economy or first class, simply select from the available airline options. Expedia has access to more than 550 airline partners across the world.
If I'm not able to travel, can I cancel my Grand Isle holiday package?
Because we understand life can throw you a few curveballs, the answer is yes. For further information, head to our Customer Service Portal. But generally speaking, if you've booked your Grand Isle holiday package in the last 24 hours, you may be able to cancel or change it free of charge. Your airline, hotel or car rental company may impose a fee if you made your booking a while ago.