Photo by Visit Greenville, South Carolina

Search Spa Hotels in Greenville

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Spa Hotels

Tonight
21 Dec - 22 Dec
Tomorrow
22 Dec - 23 Dec
Next weekend
26 Dec - 28 Dec
In two weeks
2 Jan - 4 Jan

Our top choices for Greenville hotels with a spa

Spa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (421)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is 7.078.735 ₫
7.998.970 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Grand Bohemian Lodge Greenville, Autograph Collection
Couples treatment room(s), body treatments, body wraps, body scrubs
Hotel Hartness

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (631)
"Beautiful location, friendly staff"
United States
Andrew
The price is 3.982.512 ₫
5.269.316 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Hotel Hartness
Courtyard
Hotel Domestique

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.8 out of 10, Exceptional, (31)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is 7.236.625 ₫
7.960.288 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Hotel Domestique
View from property
The Orchard Inn

The Orchard Inn

The Orchard Inn
3.0 star property
Saluda
9.4 out of 10, Exceptional, (139)
"Friendly and helpful staff. Excellent breakfast."
United States
John E
The Orchard Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Greenville Hotel Reviews

Frequently asked questions

Looking to holiday at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travellers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your holiday. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
How many spa hotels will I find in Greenville?
Among Expedia's 685 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Greenville Zoo and Fluor Field at the West End.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas which offer services including facials and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on holiday.