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Our top choices for Islamorada hotels with a spa

Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
2.5 star property
Rock Harbor
9.8 out of 10, Exceptional, (295)
"The Kona Kai Resort was perfect for us. We especially appreciated the small resort with quiet spaces to relax, read and admire the view. "
United States
Bastianella
Kona Kai Resort and Gallery - Adults Only

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1001)
"Beautiful location, great views, very clean property, room was great (great bed), friendly staff."
United States
Scott
The price is 9.032.219 ₫
11.612.985 ₫ total
includes taxes & fees
19 Jan - 20 Jan 2026
Playa Largo Resort & Spa, Autograph Collection

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1278)
"Fabulous waterfront, activities, and dining as well as the staff. "
Canada
David
The price is 10.499.685 ₫
13.736.693 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Cheeca Lodge & Spa

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.8 out of 10, Exceptional, (70)
"Great for family vacation with kids. love it"
United States
Dixania
The price is 16.025.835 ₫
19.479.679 ₫ total
includes taxes & fees
12 Jan - 13 Jan 2026
The Islands of Islamorada

Reefhouse Resort & Marina

Reefhouse Resort & Marina
3.5 star property
Key Largo
9.2 out of 10, Wonderful, (1331)
"Nice hotel with great staff."
United States
David
The price is 6.556.917 ₫
8.429.983 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Reefhouse Resort & Marina

Hawks Cay Resort

Hawks Cay Resort
4.0 star property
Marathon
8.0 out of 10, Very good, (1003)
"Excellent place for family vacation "
United States
Aneesah
The price is 7.426.093 ₫
10.193.247 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hawks Cay Resort

Premium Floating Bungalow by Stay Ombi

Premium Floating Bungalow by Stay Ombi
3.5 star property
Key Largo
The price is 33.137.164 ₫
37.279.309 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Premium Floating Bungalow by Stay Ombi
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Islamorada Hotel Reviews

Frequently asked questions

Looking for a spa hotel in Islamorada?
Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Travellers love the sea views in Islamorada. Make sure you enjoy activities such as snorkelling and fishing during your stay. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday.
How many spa hotels will I find in Islamorada?
Among Expedia's 912 accommodation options in Islamorada, there is 1 spa hotel.
What's there to see and do in Islamorada?
Enjoy Islamorada with a stop at Everglades National Park, Florida Keys Brewing Co. and Bud n' Mary's Dive Center. If you have some spare time during your trip, you might want to check out Islamorada County Park and Founders Park.
What is a Islamorada spa hotel?
Spa hotels in Islamorada provide lodging and have a full on-site spa offering services including couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on holiday.