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Check availability on Key Largo Luxury Hotels

Our top choices for Key Largo luxury hotels

Exterior
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
8.8 out of 10, Excellent, (1000)
"Beautiful location, great views, very clean property, room was great (great bed), friendly staff."
United States
Scott
The price is 9.031.533 ₫
11.612.103 ₫ total
includes taxes & fees
19 Jan - 20 Jan 2026
Playa Largo Resort & Spa, Autograph Collection
Property grounds
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
4.0 star property
Key Largo
8.6 out of 10, Excellent, (1001)
"Beautiful Hotel and Calusa Restaurant was outstanding "
United States
Darlene
The price is 10.555.398 ₫
13.326.064 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Baker's Cay Resort Key Largo, Curio Collection by Hilton
Exterior
Islander Resort

Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1003)
"The resort was perfect Everyone from checking in and during our stay could not have been nicer and helpful"
United States
Theresa
The price is 7.370.720 ₫
10.068.931 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Islander Resort
Alligator Reef Oceanfront Room King Lanai with Queen Sofabed | View from room
Amara Cay Resort

Amara Cay Resort

Amara Cay Resort
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1262)
"Friendly staff and beautiful property !"
United States
ron
The price is 6.201.276 ₫
8.723.823 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Amara Cay Resort
In-room safe, individually decorated, individually furnished
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
4.0 star property
Islamorada
9.0 out of 10, Wonderful, (116)
"Beautiful place to stay"
United States
Jonathan
The price is 6.915.837 ₫
9.528.168 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Suite, 1 King Bed with Sofa bed, Ocean View | Egyptian cotton sheets, premium bedding, pillow-top beds, in-room safe
La Siesta Resort & Villas

La Siesta Resort & Villas

La Siesta Resort & Villas
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1001)
"Great stay and beautiful space"
United States
Amir
The price is 5.490.528 ₫
7.924.230 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
La Siesta Resort & Villas
On the beach, sun-loungers, beach umbrellas, beach towels
The Islands of Islamorada

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.8 out of 10, Exceptional, (69)
"Great for family vacation with kids. love it"
United States
Dixania
The price is 16.031.316 ₫
19.486.341 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
The Islands of Islamorada
Balcony
Cheeca Lodge & Spa

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1271)
"It was awesome, great service, staff members are helpful, clean and tidy room with excellent views!"
United States
Sami
The price is 10.503.276 ₫
13.741.391 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Cheeca Lodge & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Key Largo Hotel Reviews

Sunset Cove Beach Resort

Sunset Cove Beach Resort

10/10 Excellent
"Very welcoming to my dog, very clean, quaint, beautiful grounds."
Pamela 3-night trip
Posted 4 days ago
Sunset Cove Beach Resort
Reefhouse Resort & Marina

Reefhouse Resort & Marina

10/10 Excellent
"Staff was amazing and food was excellent"
Elena 3-night trip
Posted 2 weeks ago
Reefhouse Resort & Marina

Frequently asked questions

Are you searching for a great accommodation for your luxury holiday in Key Largo?
Known for its sunsets and boating, Key Largo also has some interesting things to see and do including Everglades National Park, so you may want to take in the local sights during your visit.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 29°C, while the coldest months are January and February, with an average of 22°C. Average annual precipitation for Key Largo is 1122 mm.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Everglades National Park, Jimmy Johnson's Big Chill and Jacob's Aquatic Center. If you have a little extra time during your trip, you might want to make a stop at Bluefin Rock Harbor Marina and John Pennekamp Coral Reef State Park.