Lodging Image

Search Hotels in Main Street Fort Pierce, Fort Pierce

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
4 Sep - 6 Sep
In two weeks
11 Sep - 13 Sep

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Main Street Fort Pierce hotels

A hotel room with two beds, a small round table, and artwork depicting a beach scene and a zebra.

1. Redfinn Inn

Redfinn Inn
2.5 star property
0.7 km from Main Street Fort Pierce
6.4 out of 10, (413 reviews)
"Great newish renovated property, super clean very quiet excellent staff!"
United States
Robert
The price is 1.373.007 ₫
1.537.768 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Redfinn Inn
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

2. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,393 reviews)
"Great place to stay and enjoy the beach!"
United States
Kathleen
The price is 2.472.716 ₫
3.257.664 ₫ total
includes taxes & fees
2 Sept - 3 Sept
Hutchinson Island Hotel
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (881 reviews)
"Great place to stay."
United States
Melissa
The price is 2.633.878 ₫
2.949.943 ₫ total
includes taxes & fees
11 Sept - 12 Sept
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
A pathway leading to a beach with palm trees and a clear blue sky.

4. Prestige Hotel Vero Beach

Prestige Hotel Vero Beach
2.0 star property
20.5 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,002 reviews)
"Great location, well kept property."
United States
HUGH
The price is 2.842.502 ₫
3.183.602 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Prestige Hotel Vero Beach
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

5. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.4 out of 10, Very good, (1,001 reviews)
"Very clean friendly staff good breakfast"
United States
riad
The price is 2.294.864 ₫
2.570.248 ₫ total
includes taxes & fees
2 Sept - 3 Sept
La Quinta Inn & Suites by Wyndham Ft. Pierce
A modern bar area with wooden tables and blue chairs, featuring black pendant lights and a large abstract mural on the wall.

6. TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95
3.0 star property
21.9 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,006 reviews)
"I love the cleanliness of the rooms and property and the beautiful decor. Breakfast was also very good!"
United States
Melinda
The price is 2.558.252 ₫
2.865.243 ₫ total
includes taxes & fees
3 Sept - 4 Sept
TownePlace Suites by Marriott Port St. Lucie I-95
A hotel lobby with a long dining table, multiple chairs, and a coffee bar with various beverages.

7. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,003 reviews)
"EVERYTHING WAS EXCELLENT"
United States
ROOSEVELT
The price is 2.330.852 ₫
2.610.554 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Hampton Inn & Suites Ft. Pierce
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

8. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (958 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is 2.172.297 ₫
2.432.973 ₫ total
includes taxes & fees
6 Sept - 7 Sept
Comfort Suites Fort Pierce I-95
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

9. The Royal Inn Beach Hotel Hutchinson Island

The Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,000 reviews)
"Close to the ocean! Easy beach access."
United States
Lisa
The price is 2.679.650 ₫
3.419.760 ₫ total
includes taxes & fees
15 Sept - 16 Sept
The Royal Inn Beach Hotel Hutchinson Island
A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

10. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,005 reviews)
"Nice hotel, good location"
United States
Wilmer
The price is 2.416.127 ₫
2.706.061 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Fairfield Inn & Suites by Marriott Fort Pierce
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

11. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,001 reviews)
"Clean rooms - great hotel to stay at!"
United States
Richard
The price is 1.558.421 ₫
1.745.432 ₫ total
includes taxes & fees
6 Sept - 7 Sept
Days Inn & Suites by Wyndham Fort Pierce I-95
A hotel entrance with a welcome sign, a black mat, and two potted plants.

12. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.0 out of 10, Very good, (1,268 reviews)
"Love the hotel"
United States
Eric
The price is 1.760.004 ₫
1.971.204 ₫ total
includes taxes & fees
31 Aug - 1 Sept
At Home Inn
An outdoor patio area with a fire pit, red and black wicker furniture, and string lights.

13. Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,000 reviews)
"Great stay"
United States
Sara
The price is 2.633.878 ₫
2.949.943 ₫ total
includes taxes & fees
2 Sept - 3 Sept
Residence Inn by Marriott Port St. Lucie
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

14. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,003 reviews)
"Great location! Lots of food options and stores nearby. High ceilings, spacious rooms and great breakfast included!"
Canada
Roxana
The price is 2.274.002 ₫
2.546.882 ₫ total
includes taxes & fees
6 Sept - 7 Sept
SpringHill Suites Port St. Lucie
A modern lobby with a fireplace, comfortable seating, and a framed painting above the fireplace.

15. Homewood Suites by Hilton Port Saint Lucie-Tradition

Homewood Suites by Hilton Port Saint Lucie-Tradition
3.0 star property
23.1 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,001 reviews)
"Great stay. Friendly and helpful staff. Conveniently located to all the shops and restaurants."
United States
Christina
The price is 2.437.590 ₫
2.730.110 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Homewood Suites by Hilton Port Saint Lucie-Tradition
A modern kitchen with wooden cabinets, a stainless steel refrigerator, and a bar stool.

16. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (701 reviews)
"Great place to stay. Clean. Friendly staff. If in the area again I will be staying here."
United States
Trever
The price is 3.025.048 ₫
3.388.053 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Staybridge Suites Vero Beach by IHG
An outdoor seating area with fire feature, stone walls, and a view into the building.

17. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (269 reviews)
"Nice little breakfast...very clean and easy check in and check out..."
United States
JERRY
The price is 2.972.210 ₫
3.328.869 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Home2 Suites by Hilton Ft. Pierce I-95
A hotel atrium with a central lawn, palm trees, and a blue umbrella.

18. Star Suites: An Extended Stay Hotel

Star Suites: An Extended Stay Hotel
2.5 star property
24.2 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (761 reviews)
"Pet friendly hotel. Nice and clean and the front desk was super friendly and helpful. Loved the location...will definitely stay here again!"
United States
William
The price is 2.416.127 ₫
2.706.114 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Star Suites: An Extended Stay Hotel

19. Red Roof Inn Ft Pierce

Red Roof Inn Ft Pierce
2.0 star property
4.6 km from Main Street Fort Pierce
7.2 out of 10, Good, (812 reviews)
"Decent"
United States
Colton
The price is 1.929.772 ₫
2.161.345 ₫ total
includes taxes & fees
31 Aug - 1 Sept
Red Roof Inn Ft Pierce
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

20. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,005 reviews)
"Great short term stay"
United States
Patsy
The price is 2.229.408 ₫
2.496.936 ₫ total
includes taxes & fees
13 Sept - 14 Sept
Best Western Port St. Lucie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

When in Lakewood Park, you can plan a visit to McKee Botanical Garden and Harbor Branch Ocean Discovery Center, some noteworthy sights in the nearby area.

Spanish Lakes Country Club Village

While Spanish Lakes Country Club Village isn't home to many top sights, Harbor Branch Ocean Discovery Center and McKee Botanical Garden are some notable places to visit nearby.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While there might not be top attractions in Spanish Lakes Fairways, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

While Meadowood isn't home to many top sights, Endless Summer Vineyard & Winery and Al's Family Farms are some notable places to visit nearby.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

While Panther Woods may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95

10/10 Excellent
"Great hotel in nice location."
Michael 1-night trip
Posted 1 hour ago
TownePlace Suites by Marriott Port St. Lucie I-95

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighbourhood that travellers like for its waterfront, art and shopping. Make sure that you visit Sunrise Theater and Fort Pierce City Marina as part of your Main Street Fort Pierce travel plans.
How many hotels will I find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodation options in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! Most room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best options available in Main Street Fort Pierce.
What is there to do in this Fort Pierce neighbourhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce City Marina and Fort Pierce Farmer's Market are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.