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25 Dec - 26 Dec
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26 Dec - 28 Dec
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Our top choices for Mark Twain Medical Center hotels

Exterior
Robins Nest Bed & Breakfast

Robins Nest Bed & Breakfast

Robins Nest Bed & Breakfast
3.5 star property
1.6 km from Mark Twain Medical Center
9.6 out of 10, Exceptional, (144)
"Very nice home well decorated with antiques. Breakfast was excellent. "
United States
John
The price is 3.947.400 ₫
4.421.088 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Robins Nest Bed & Breakfast
Premium Room, 2 Double Beds, Non Smoking, Refrigerator & Microwave | Desk, free WiFi, bed sheets
Sierra Inn

Sierra Inn

Sierra Inn
2.5 star property
1.2 km from Mark Twain Medical Center
7.6 out of 10, Good, (150)
"Clean and pleasant staff. Quiet location "
United States
Shelton
The price is 2.193.372 ₫
2.663.012 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Sierra Inn
Room, 1 Queen Bed, Kitchenette, Garden View (The Bonnie Inn Unit 6) | View from room
The Bonnie Inn Unit 6

The Bonnie Inn Unit 6

The Bonnie Inn Unit 6
3.0 star property
1.7 km from Mark Twain Medical Center
8.6 out of 10, Excellent, (9)
"I will definitely stay there again."
United States
Karyn
The price is 3.273.974 ₫
4.698.438 ₫ total
includes taxes & fees
26 Dec - 27 Dec
The Bonnie Inn Unit 6
Property grounds
The Bonnie Inn Unit 1

The Bonnie Inn Unit 1

The Bonnie Inn Unit 1
2.0 star property
1.7 km from Mark Twain Medical Center
8.6 out of 10, Excellent, (4)
"Very Cute Comfortable Room We had a nice visit "
United States
ERIK
The price is 3.273.974 ₫
4.698.438 ₫ total
includes taxes & fees
27 Dec - 28 Dec
The Bonnie Inn Unit 1
Outdoor pool
Hotel Leger

Hotel Leger

Hotel Leger
2.0 star property
12.7 km from Mark Twain Medical Center
The price is 5.394.780 ₫
6.042.153 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hotel Leger
Property amenity
Travelodge by Wyndham Angels Camp CA

Travelodge by Wyndham Angels Camp CA

Travelodge by Wyndham Angels Camp CA
2.0 star property
14.4 km from Mark Twain Medical Center
8.0 out of 10, Very good, (1000)
"Very clean rooms well maintained grounds. You can tell they take pride of this place "
United States
MICHAEL
The price is 1.968.437 ₫
2.204.649 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Travelodge by Wyndham Angels Camp CA
Front of property
The 10th Green Inn

The 10th Green Inn

The 10th Green Inn
3.0 star property
14.3 km from Mark Twain Medical Center
8.0 out of 10, Very good, (112)
"Very cozy and wonderful location "
United States
Kristyn
The 10th Green Inn
Lobby
Best Western Cedar Inn & Suites

Best Western Cedar Inn & Suites

Best Western Cedar Inn & Suites
2.5 star property
16.2 km from Mark Twain Medical Center
9.0 out of 10, Wonderful, (1004)
"Courteous staff, clean room, good breakfast. Would definitely stay there again if in the area. "
United States
Elizabeth
The price is 2.738.443 ₫
3.067.056 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Best Western Cedar Inn & Suites
BBQ/picnic Area
Jumping Frog Motel

Jumping Frog Motel

Jumping Frog Motel
2.0 star property
15.9 km from Mark Twain Medical Center
7.2 out of 10, Good, (309)
"Jumping Frog provided a clean room and hot shower at a decent price. I would book here again"
United States
Terese
The price is 2.348.479 ₫
2.630.296 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Jumping Frog Motel
Standard Single Room, 1 King Bed, Accessible, Refrigerator & Microwave | Individually furnished, desk, laptop workspace, soundproofing
Angels Inn

Angels Inn

Angels Inn
2.5 star property
16.7 km from Mark Twain Medical Center
7.4 out of 10, Good, (800)
"Very nice and comfortable place "
United States
April
Angels Inn
In-room safe, desk, laptop workspace, blackout curtains
Holiday Inn Express Hotel & Suites Jackson by IHG

Holiday Inn Express Hotel & Suites Jackson by IHG

Holiday Inn Express Hotel & Suites Jackson by IHG
3.0 star property
18.8 km from Mark Twain Medical Center
8.2 out of 10, Very good, (577)
"Clean facilities rooms. Easy check in and out "
United States
Keith
The price is 2.921.076 ₫
3.277.301 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express Hotel & Suites Jackson by IHG
Exterior
The Victoria Inn

The Victoria Inn

The Victoria Inn
3.5 star property
19 km from Mark Twain Medical Center
8.8 out of 10, Excellent, (201)
"Always love the stay at the Victoria Inn. Will be returning again soon!"
United States
Michelle
The price is 4.500.036 ₫
5.130.042 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
The Victoria Inn
Lobby
National Hotel Jackson, Tapestry Collection by Hilton

National Hotel Jackson, Tapestry Collection by Hilton

National Hotel Jackson, Tapestry Collection by Hilton
2.5 star property
19.7 km from Mark Twain Medical Center
9.4 out of 10, Exceptional, (1000)
"Everything was wonderful, staff, rooms, location Great holiday getaway"
United States
Marcia
The price is 2.789.496 ₫
3.124.235 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
National Hotel Jackson, Tapestry Collection by Hilton
Outdoor pool
Murphys Inn Motel

Murphys Inn Motel

Murphys Inn Motel
2.5 star property
19.6 km from Mark Twain Medical Center
8.6 out of 10, Excellent, (1000)
"Nice place to stay near Murphys Main Street"
United States
saurav
Murphys Inn Motel
Interior entrance
Murphys Suites

Murphys Suites

Murphys Suites
2.0 star property
19.8 km from Mark Twain Medical Center
9.0 out of 10, Wonderful, (1000)
"Great staff and great location - love the free soft serve ice cream in the lobby!"
United States
Stewart
Murphys Suites
Lobby
Best Western Amador Inn

Best Western Amador Inn

Best Western Amador Inn
2.5 star property
19.5 km from Mark Twain Medical Center
7.6 out of 10, Good, (1001)
"The entire overall experience was amazing"
United States
Stephen
The price is 2.412.125 ₫
2.701.580 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Best Western Amador Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mark Twain Medical Center Hotel Reviews

Hotels near other Mark Twain Medical Center attractions

Calaveras County Museum Complex

3.5/5 (2 reviews)
You can spend an afternoon browsing the exhibits at Calaveras County Museum Complex during your trip to San Andreas. You can seek out the campsites while in the area.
See properties

Mokelumne Hill Library

After visiting Mokelumne Hill Library, make a plan to see the other sights and activities in Mokelumne Hill. Wander the riverfront in this relaxing area.
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Frequently asked questions

What's the area like around Mark Twain Medical Center?
Mark Twain Medical Center is located in San Andreas. You'll find 11 hotels and other accommodations within a few miles for a convenient home base.
How many hotels will I be able to find close to Mark Twain Medical Center?
Expedia has 11 hotels and other accommodation options a few miles from Mark Twain Medical Center.
If I need to cancel the hotel reservation for my stay near Mark Twain Medical Center, will I receive a refund?
Yes! Most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and get a refund within 24 hours of your booking. Add dates, click "Search", then you can use the "fully refundable" filter to view the best options available near Mark Twain Medical Center.