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Our top choices for Midtown business-friendly hotels

La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
Midtown
9.8 out of 10, Exceptional, (542)
"great neighborhood, friendly staff, and delicious breakfast"
United States
Anna
The price is 4.710.385 ₫
5.511.150 ₫ total
includes taxes & fees
22 Dec - 23 Dec
La Maison in Midtown an urban B&B

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Downtown Houston
8.4 out of 10, Very good, (3959)
"Rooms were great and the staff was absolutely amazing. "
United States
Elmer
The price is 2.091.039 ₫
2.446.515 ₫ total
includes taxes & fees
27 Dec - 28 Dec
Club Quarters Hotel Downtown, Houston

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston
9.4 out of 10, Exceptional, (58)
"Very nice and clean staff was great!!! Will vist again if im in that area "
United States
Roderick
The price is 2.108.095 ₫
2.466.471 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Best Western Plus Pearland/Houston Medical Center Hotel

TownePlace Suites by Marriott Humble Intercontinental Airport

TownePlace Suites by Marriott Humble Intercontinental Airport
2.5 star property
Humble
9.6 out of 10, Exceptional, (96)
"very nice hotel"
United States
Bernardo
The price is 2.657.815 ₫
3.123.598 ₫ total
includes taxes & fees
25 Dec - 26 Dec
TownePlace Suites by Marriott Humble Intercontinental Airport

The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria
8.4 out of 10, Very good, (1472)
"Wonderful hotel!"
United States
Debbie
The price is 2.925.934 ₫
3.423.342 ₫ total
includes taxes & fees
27 Dec - 28 Dec
The Royal Sonesta Houston Galleria

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center
8.4 out of 10, Very good, (1773)
"Loved the room, clean, friendly staff. Would reccomend :)"
United States
Rolando
The price is 2.264.143 ₫
2.679.572 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hilton Houston Plaza/Medical Center

Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1345)
"Bed was very nice and comfortable! "
United States
Luis
The price is 2.747.286 ₫
3.295.902 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Magnolia Hotel Houston, A Tribute Portfolio Hotel

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
Houston
9.0 out of 10, Wonderful, (1082)
"Courteous staff, clean rooms, excellent location."
United States
Rebecca
The price is 2.661.762 ₫
3.114.263 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Courtyard by Marriott Houston Intercontinental Airport

Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3608)
"Great hotel I would definitely stay again"
United States
Newassa
The price is 3.430.950 ₫
4.014.211 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Blossom Hotel Houston, Curio Collection by Hilton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Midtown Hotel Reviews

Frequently asked questions

Why book your business-friendly hotel in Midtown with Expedia?
With handy amenities like meeting rooms, housekeeping and free WiFi, our business-friendly accommodation come with all you'll need to get the job done — and then unwind! Enter your preferred travel dates and destination and we'll help you with the rest.
How can I find cheap business-friendly hotels in Midtown?
Select the "business friendly" filter, located just under the "traveller experience" heading, to find cheap business-friendly hotels in Midtown. Then fine-tune your search by your preferred hotel star rating and budget. Basing yourself outside the city centre can also help you save.