Search Hotels in Mira Mesa, San Diego

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Check prices for these dates

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10 Dec - 11 Dec
Tomorrow
11 Dec - 12 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

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Our top choices for Mira Mesa hotels

Terrace/patio
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4.0 star property
22 km from Mira Mesa
8.4 out of 10, Very good, (6038)
"Always an amazing stay"
United States
Jana
The price is 3.563.906 ₫
4.896.902 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wyndham San Diego Bayside
Outdoor pool
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4.0 star property
Gaslamp Quarter, 23.2 km from Mira Mesa
9.0 out of 10, Wonderful, (3142)
"Great stay"
United States
Laurence
The price is 4.484.176 ₫
6.410.975 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hard Rock Hotel San Diego
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace
Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel

3.5 star property
28.6 km from Mira Mesa
9.2 out of 10, Wonderful, (3503)
"Great friendly staff "
United States
mohammed
The price is 3.061.821 ₫
3.373.974 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Best Western Plus Marina Gateway Hotel
Serves dinner and happy hour
The Horton Grand, Downtown/Gaslamp Quarter

The Horton Grand, Downtown/Gaslamp Quarter

3.5 star property
Marina District, 22.9 km from Mira Mesa
9.0 out of 10, Wonderful, (2695)
"Clean facilities and friendly staff!"
United States
EMMA
The Horton Grand, Downtown/Gaslamp Quarter
Property entrance
The Bristol Hotel San Diego

The Bristol Hotel San Diego

3.5 star property
22.2 km from Mira Mesa
8.6 out of 10, Excellent, (1443)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Garden
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

4.0 star property
17.6 km from Mira Mesa
9.2 out of 10, Wonderful, (2957)
"Everything was super comfortable and the room was surprisingly affordable for the amenities you get. We will definitely stay there again if we go to San Diego."
United States
Eric
The price is 4.010.978 ₫
4.610.419 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Legacy Resort Hotel & Spa
Exterior
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

3.0 star property
Gaslamp Quarter, 23 km from Mira Mesa
9.0 out of 10, Wonderful, (1229)
"Very nice clean room and amenities and staff was pleasant and we love the location. "
United States
Arnold
The price is 3.613.703 ₫
4.189.908 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter
Lobby
Gaslamp Plaza Suites

Gaslamp Plaza Suites

3.5 star property
Gaslamp Quarter, 22.4 km from Mira Mesa
9.0 out of 10, Wonderful, (1012)
"very good location, good and quiet AC system (not the noise window AC)."
United States
Henry
The price is 2.979.810 ₫
3.389.534 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Gaslamp Plaza Suites
Front of property
The Sofia Hotel

The Sofia Hotel

3.5 star property
22.3 km from Mira Mesa
8.4 out of 10, Very good, (1648)
"Great location and history to the hotel "
United States
Stephanie
The Sofia Hotel
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

3.0 star property
Gaslamp Quarter, 22.8 km from Mira Mesa
9.4 out of 10, Exceptional, (1000)
"Great location "
United States
Mohammad
The price is 2.966.625 ₫
4.201.747 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Staypineapple, Hotel Z, Gaslamp San Diego
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

4.0 star property
Marina District, 23 km from Mira Mesa
9.2 out of 10, Wonderful, (1941)
"Great hotel"
United States
Farzana
The price is 4.192.830 ₫
6.248.174 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Marriott Marquis San Diego Marina
Outdoor pool, a heated pool
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

3.0 star property
17.4 km from Mira Mesa
8.0 out of 10, Very good, (2426)
"Front desk staff was kind, knowledgeable and efficient "
United States
Elizabeth
The price is 2.330.401 ₫
2.678.679 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Days Inn by Wyndham San Diego Hotel Circle
Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3.0 star property
21.6 km from Mira Mesa
8.8 out of 10, Excellent, (725)
"Great little boutique hotel ! Friendly staff as well"
Canada
Caroll
The price is 2.577.892 ₫
2.988.937 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The DEXTRO Little Italy, BW Premier Collection
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

4.0 star property
22.3 km from Mira Mesa
8.6 out of 10, Excellent, (1057)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.565.224 ₫
4.898.165 ₫ total
includes taxes & fees
19 Dec - 20 Dec
The Westin San Diego Bayview
Reception
Kings Inn San Diego

Kings Inn San Diego

2.5 star property
17.7 km from Mira Mesa
8.8 out of 10, Excellent, (3561)
"Room was very clean, and the breakfast was good"
United States
Roxana
The price is 1.973.591 ₫
2.264.695 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Kings Inn San Diego
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 star property
23.5 km from Mira Mesa
9.2 out of 10, Wonderful, (3174)
"Great stay and location!"
United States
Jason
The price is 3.180.222 ₫
3.655.507 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Bay Club Hotel & Marina
Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)
Lafayette Hotel & Club

Lafayette Hotel & Club

4.0 star property
17.9 km from Mira Mesa
9.4 out of 10, Exceptional, (1320)
"My wife loved everything about this vintage hotel."
United States
Eddie
The price is 5.957.812 ₫
6.836.721 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Lafayette Hotel & Club
Exterior
Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG

2.5 star property
30.9 km from Mira Mesa
9.2 out of 10, Wonderful, (1003)
"room is clean and staff really nice to guest. "
United States
Yu
The price is 3.401.730 ₫
3.741.903 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express San Diego South - Chula Vista by IHG
3 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sycuan Casino Resort

Sycuan Casino Resort

4.0 star property
32.8 km from Mira Mesa
9.2 out of 10, Wonderful, (1634)
"Nice hotel and friendly staff. Will definitely stay again ."
United States
Lorna
Sycuan Casino Resort
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

3.5 star property
Mission Bay, 18.8 km from Mira Mesa
9.0 out of 10, Wonderful, (3914)
"The room was spotless the bed was so comfy the Amenities were great!! The food at the restaurant very delish"
United States
Emily
The price is 3.665.430 ₫
4.740.535 ₫ total
includes taxes & fees
14 Dec - 15 Dec
The Dana on Mission Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Mira Mesa

Find the best Mira Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Mira Mesa Hotel Reviews

Hampton Inn & Suites by Hilton San Diego SeaWorld

Hampton Inn & Suites by Hilton San Diego SeaWorld

10/10 Excellent
"Leigh at the front desk."
Randolph 1-night trip
Posted 19 hours ago
Hampton Inn & Suites by Hilton San Diego SeaWorld

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Mira Mesa?
Mira Mesa is a neighbourhood that travellers like for its restaurants and bars. Consider a visit to Regal Edwards Mira Mesa as part of your Mira Mesa travel plans.
How many hotels should I expect to find in the Mira Mesa area?
Expedia has 43 hotels and other accommodation options in Mira Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.
If I need to cancel my hotel reservation in Mira Mesa, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best deals in Mira Mesa.
What is there to do in this San Diego neighbourhood?
Regal Edwards Mira Mesa is an attraction you might want to check out while you're in Mira Mesa. While you're out sightseeing in San Diego, make sure that you visit other sights such as Rancho Penasquitos Tennis Center or Lake Miramar.