Monroe County Holidays

Book a Hotel + Flight or Car together to unlock savings

Top destinations in Monroe County

River and a path way in Galena
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Columbia

Columbia
Aerial view of Fort de Chartres, Prairie du Rocher, Illinois, United States.
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Prairie du Rocher

Prairie du Rocher

Top hotels in Monroe County

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

3 out of 5
2211 Market Street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 2.786.053 ₫ per night from 5 Apr to 6 Apr
2.786.053 ₫
3.257.705 ₫ total
5 Apr - 6 Apr
includes taxes & fees
8.8/10 Excellent! (1,868 reviews)
Great location, minutes from every downtown St Louis attraction. Perfect for weekend getaways for couples or families. Happy hour was a plus!

Reviewed on 13 Mar 2026

Pear Tree Inn St. Louis Near Union Station
Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 2.611.251 ₫ per night from 22 Mar to 23 Mar
2.611.251 ₫
3.048.650 ₫ total
22 Mar - 23 Mar
includes taxes & fees
8.8/10 Excellent! (3,107 reviews)
Great hotel breakfast.

Reviewed on 13 Mar 2026

Clayton Plaza Hotel & Extended Stay
21C Museum Hotel St Louis

21C Museum Hotel St Louis

4.5 out of 5
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is 3.329.122 ₫ per night from 5 Apr to 6 Apr
3.329.122 ₫
4.024.139 ₫ total
5 Apr - 6 Apr
includes taxes & fees
9/10 Wonderful! (1,659 reviews)
The staff was good but the room looked like the bathroom needed to be mopped no amenities like normal hotels and the ceiling looked like it was patched together and was about to fall in

Reviewed on 14 Mar 2026

21C Museum Hotel St Louis
See all 1,808 properties in Monroe County
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Monroe County holiday package cost?
Starting from only , a package is your gateway to low-priced travel. Custom make your Monroe County getaway by picking from our great range of flights, hotels and rental cars.
How do I get a cheap travel package to Monroe County?
Creating your own Monroe County holiday package with Expedia is a simple way to save. We offer access to over 550 airlines and 1null000null000 properties worldwide. With such a wonderful range to pick from, you'll have no hassles creating your ideal escape.
What are the top hotels in Monroe County?
If you're on your way to Columbia, you can't go wrong with Hampton Inn St. Louis - Columbia and Super 8 by Wyndham Waterloo. Both are great bases for discovering this unique Monroe County city.
How far in advance should I book my Monroe County holiday?
While not all airlines release tickets early, you can usually start comparing international airfares on Expedia up to a year in advance. This is when you'll nab some incredible bargains. If you've left things to the last minute, you could still be in luck. Low prices occasionally emerge a few weeks before departure.
What does an Expedia Monroe County travel package include?
Expedia has all you need to lock in Monroe County getaway, but how you structure your package is your call. Pick from a combination of rental cars, flights and hotels. In search of some activities to fill in your time? Once you've made your booking, you can add them on too. No matter your budget, there's a package deal to match your needs.
What should I know before booking a Monroe County travel package?
So many places to explore, so many things to experience. With a travel package, you'll be able to afford more of them. Combine your hotels, rental cars and flights and get set to save.
Can I choose my airline with a Monroe County Expedia holiday package?
Yes — and it's easy too. Expedia has access to more than 550 partner airlines worldwide. Our packages give you the flexibility to take your pick of available flight, hotel or activity options that fit your needs.
If I'm not able to travel, can I cancel my Monroe County holiday package?
It is possible to cancel your Monroe County booking if your travel plans have been upended. Whether you'll incur a fee or not depends on your hotel, airline or car rental company. You may be able to cancel or change your booking free of charge if you booked in the last 24 hours. Visit our Customer Service Portal to find out more.

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