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Our top choices for Murphy Island hotels

Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
6.1 km from Murphy Island
9.6 out of 10, Exceptional, (1002)
"Great area"
United States
kelvin
The price is 2.660.953 ₫
3.082.714 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Sleep Inn & Suites Hannibal West
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
4.9 km from Murphy Island
9.4 out of 10, Exceptional, (165)
"Great place to stay!"
United States
Sandy
The price is 3.878.784 ₫
5.361.191 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Riverside Inn Hannibal
Down duvets, blackout curtains, iron/ironing board, free WiFi
Lighthouse Inn & Suites

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
4.3 km from Murphy Island
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is 4.442.147 ₫
5.101.806 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Lighthouse Inn & Suites
Desk, iron/ironing board, WiFi, bed sheets
Best Western On The River

Best Western On The River

Best Western On The River
2.5 star property
4.7 km from Murphy Island
8.6 out of 10, Excellent, (1002)
"Great stay! Clean and cozy!!"
United States
Courtney
The price is 2.656.744 ₫
3.051.349 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Best Western On The River
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
6 km from Murphy Island
8.0 out of 10, Very good, (1008)
"Very nice place to stay during a snow storm. "
United States
Teresa
The price is 2.089.565 ₫
2.420.760 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Quality Inn & Suites Hannibal West
In-room safe, desk, blackout curtains, iron/ironing board
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
7.3 km from Murphy Island
7.6 out of 10, Good, (659)
"Below average facility. Needs some upgrades and could use a good cleaning. Staff was helpful."
United States
JACQUI
The price is 2.124.290 ₫
2.518.668 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Comfort Inn & Suites - Hannibal
Lobby lounge
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
5.7 km from Murphy Island
7.4 out of 10, Good, (1002)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is 1.525.543 ₫
1.752.046 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Hannibal, MO
Exterior
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
5.6 km from Murphy Island
7.2 out of 10, Good, (1000)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is 1.469.158 ₫
1.687.327 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Super 8 by Wyndham Hannibal
Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, free WiFi, bed sheets
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
7.4 km from Murphy Island
7.4 out of 10, Good, (215)
"Left before breakfast great cup of coffee"
United States
David
The price is 1.657.341 ₫
1.903.456 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Days Inn by Wyndham Hannibal
Indoor pool
Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
7.5 km from Murphy Island
7.2 out of 10, Good, (152)
"The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three months.!"
United States
Shawn
The price is 1.449.516 ₫
1.676.545 ₫ total
includes taxes & fees
24 Dec - 25 Dec
Howard Johnson BY Wyndham Hannibal
Indoor pool
Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
7.4 km from Murphy Island
6.4 out of 10, (735)
" There actually was a pool & there actually was a hot breakfast. It didn't just say there was & not have what was listed. One of the best we've been to as of late. Would stay again if in the area. "
United States
Thomas
The price is 1.709.955 ₫
1.977.134 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Baymont by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Murphy Island Hotel Reviews

Heritage Hotel Quincy

Heritage Hotel Quincy

10/10 Excellent
"Clean room, quiet surroundings, breakfast"
Michael 2-night trip
Posted 10 days ago
Heritage Hotel Quincy

Hotels near other Murphy Island attractions

Mark Twain Memorial Lighthouse

4.3/5 (93 reviews)
You can find out about the history of Hannibal with a trip to Mark Twain Memorial Lighthouse. While in this walkable area, you can savour the top-notch restaurants.
See properties

Riverview Park

You can find out about the history of Hannibal when you stop by Riverview Park. While in this family-friendly area, you can savour the top-notch restaurants.
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Frequently asked questions

What's the area like around Murphy Island?
Murphy Island is located in Palmyra. You'll find 52 hotels and other accommodations within a few miles for a convenient home base.
How many hotels will I be able to find near Murphy Island?
Expedia has 52 hotels and other accommodation options a few miles from Murphy Island.
If I need to cancel the hotel reservation for my stay near Murphy Island, will I receive a refund?
Yes, you'll find most hotel reservations are fully refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view the best deals available near Murphy Island.
What can I see and do near Murphy Island?
Jim's Journey: The Huck Finn Freedom Center, Mark Twain Boyhood Home and Museum and Molly Brown Museum and Home feature captivating exhibits. Mark Twain Memorial Lighthouse, Rockcliffe Mansion and Planters Barn Theater are landmarks that you won't want to miss. You might spend a leisurely day outdoors at Sawyer's Creek Fun Park and Sodalis Nature Preserve.

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