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Check prices for these dates

Tonight
11 Dec - 12 Dec
Tomorrow
12 Dec - 13 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Our top choices for Panama City holiday rentals

Superior Double Room | Terrace/patio
La Isabela Suites

Aparthotel in Casco Viejo

La Isabela Suites
3.5 star property
10.0 out of 10, Exceptional, (166)
"The room was spotless, the location perfect, and the staff was absolutely superb!"
United States
Gregory
La Isabela Suites
50-inch LED TV with satellite channels
Arcadia Condo Suites

Aparthotel in Costa del Este

Arcadia Condo Suites
2.5 star property
9.4 out of 10, Exceptional, (157)
"Everything was great, helpful staff, great room , clean, excellent service!"
United States
Gregory Walter
The price is 1.740.420 ₫
3.132.756 ₫ total
includes taxes & fees
15 Dec - 16 Dec
Arcadia Condo Suites
Studio, 1 King Bed, Non Smoking, Connecting Rooms | Premium bedding, in-room safe, individually decorated
Las Clementinas

Aparthotel in Casco Viejo

Las Clementinas
3.5 star property
9.4 out of 10, Exceptional, (169)
"Our stay at Las Clementinas was amazing. The ambiance, decor, and central location to all things in Casco Viejo made our trip magical. Not only was the hotel beautiful, the staff was incredibly warm, helpful and welcoming. The restaurant in the hotel was absolutely delicious. I would stay here ten times over. "
United States
Amanda
The price is 3.392.113 ₫
3.731.324 ₫ total
includes taxes & fees
13 Dec - 14 Dec
Las Clementinas
Outdoor pool, free pool cabanas, pool loungers
Yoo Panama & Arts Tower

Apartment in Bella Vista

Yoo Panama & Arts Tower
3.0 star property
9.4 out of 10, Exceptional, (46)
"Nice stay"
United States
ANGEL
Yoo Panama & Arts Tower
Outdoor pool
Studio Apartment with Ocean View

Apartment in Calidonia

Studio Apartment with Ocean View
3.0 star property
10.0 out of 10, Exceptional, (1)
"Muy amables en general "
Mexico
Algis
The price is 1.714.050 ₫
1.885.455 ₫ total
includes taxes & fees
16 Dec - 17 Dec
Studio Apartment with Ocean View
Standard Apartment | Living area | Flat-screen TV
Torres de Alba Hotel & Suites

Aparthotel in Bella Vista

Torres de Alba Hotel & Suites
3.5 star property
8.8 out of 10, Excellent, (483)
"The buffet bar and great customer service. "
United States
Kayhiuska
Torres de Alba Hotel & Suites
Apartment (14D) | Private kitchen
Mini Design By Wynwood House

Apartment in Bella Vista

Mini Design By Wynwood House
2.0 star property
The price is 3.241.911 ₫
4.290.920 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Mini Design By Wynwood House
Apartment, 2 Bedrooms (2C) | Iron/ironing board, free WiFi, bed sheets
Donovan By Wynwood House

Apartment in Casco Viejo

Donovan By Wynwood House
3.0 star property
8.4 out of 10, Very good, (45)
"I always love to stay at Wynwood properties in Panama "
United States
Alberto B
The price is 2.729.295 ₫
3.793.325 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Donovan By Wynwood House
Apartment | 1 bedroom, Internet
w Central 1BR in Vibrant Obarrio

Apartment in Bella Vista

w Central 1BR in Vibrant Obarrio
2.0 star property
The price is 2.462.718 ₫
3.492.179 ₫ total
includes taxes & fees
14 Dec - 15 Dec
w Central 1BR in Vibrant Obarrio
Outdoor pool
Wanders Panama by Boutique Apartments

Apartment in San Francisco

Wanders Panama by Boutique Apartments
4.0 star property
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is 4.219.200 ₫
8.673.093 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Wanders Panama by Boutique Apartments
Apartment, 3 Bedrooms, Accessible, Pool View | Children’s area
Charming 3 Bedroom Apartment in San Miguelito, Panama City

Apartment in José Domingo Espinar

Charming 3 Bedroom Apartment in San Miguelito, Panama City
2.0 star property
The price is 1.876.562 ₫
2.064.218 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Charming 3 Bedroom Apartment in San Miguelito, Panama City
Outdoor pool
Yoo by Wynwood House

Condo in Calidonia

Yoo by Wynwood House
4.0 star property
9.2 out of 10, Wonderful, (5)
"I will be back!"
United States
Jeffrey
The price is 5.316.192 ₫
6.776.035 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Yoo by Wynwood House
Apartment, City View | Living area
YC 2301-C l Apartamento 2BR en av balboa

Apartment in Bella Vista

YC 2301-C l Apartamento 2BR en av balboa
2.0 star property
9.6 out of 10, Exceptional, (4)
"Roberto the host was very accommodating with all our every need, from stowing our Luggage til room was ready to providing us Directions at all times during our stay. Gracias Roberto!!!"
United States
sonia
The price is 2.751.671 ₫
4.344.688 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
YC 2301-C l Apartamento 2BR en av balboa
Apartment (CC4B) | Balcony
Casa Contemporanea by Wynwood House

Apartment in Casco Viejo

Casa Contemporanea by Wynwood House
4.0 star property
8.2 out of 10, Very good, (20)
"Great place!"
United States
Jad
The price is 3.534.474 ₫
4.546.846 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Casa Contemporanea by Wynwood House
Apartment | 1 bedroom, Internet
w Grandiose 1BR w Balcony in San Felipe

Apartment in Casco Viejo

w Grandiose 1BR w Balcony in San Felipe
2.0 star property
10.0 out of 10, Exceptional, (1)
"limpieza impecable, el apartamento es muy comodo y esta super bien amoblado. Acceso a la Plaza Herrera."
Costa Rica
Javier
The price is 2.210.285 ₫
3.433.796 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
w Grandiose 1BR w Balcony in San Felipe
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Panama City Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Always nice to stay and have experience the service of the company excels my expectation "
Dana 1-night trip
Posted 2 days ago
Hotel Riu Plaza Panama

Frequently asked questions

Can I find holiday rentals in Panama City?

Yes, there are holiday rentals in Panama City close to Panama Canal Railway, or you can select a more secluded option if you're looking for a relaxing stay. Tourists like the array of shops and top-notch restaurants in Panama City. While you're in the area, grab a bite or have a drink at the lively bars and cafes.

How many holiday rentals are there in Panama City?

With 55 Expedia holiday rentals, you're guaranteed to find just the right place for your Panama City stay.

What can I see and do in Panama City?

Cultural attractions include National Theater and Interoceanic Canal Museum, whereas Cinta Costera and Miraflores Locks are a couple of picturesque spots to enjoy the outdoors. Albrook Shopping Mall and Via Espana are other places to visit while you're in town.

What are holiday rentals like in Panama City?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Panama City. Holiday rentals offer extras like WiFi and washers and dryers so you'll feel right at home. If you're concerned about a clean environment, holiday rentals can provide a sense of privacy away from public hotel lifts and lobbies bustling with people while still allowing you a great travel experience. You'll also get more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great choice for family gatherings.