Search Business Hotels in Prague 10

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Prague 10 Business Hotels

Our top choices for Prague 10 business-friendly hotels

Comfort Hotel Prague City East

Comfort Hotel Prague City East
3.0 star property
Prague 10
9.0 out of 10, Wonderful, (108)
"Great place to stay, breakfast was incredible."
United States
Darwin
The price is 1.687.591 ₫
2.016.109 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Comfort Hotel Prague City East

Hotel Astra

Hotel Astra
3.0 star property
Prague 10
7.8 out of 10, Good, (165)
"Great, freshly cooked breakfast buffet, food options for vegan and vegetarian. No kettle in the room. No enough plugs to charge phone, no fan or ac, window curtains were not fully blocking the light from outside, toiletries include just hand wash and body wash, no coffee machine or hot water in the room. "
United Kingdom
Poonam
Hotel Astra

Iris Hotel Eden - Czech Leading Hotels

Iris Hotel Eden - Czech Leading Hotels
4.0 star property
Prague 10
8.4 out of 10, Very good, (1000)
"The staff was super friendly and helpful. The hotel itself is clean and spacious in a great location."
Switzerland
Sanja
Iris Hotel Eden - Czech Leading Hotels

Hotel Peko

Hotel Peko
3.0 star property
Prague 10
7.0 out of 10, Good, (4)
"Large rooms, good shower, very clean, comfortable bed, but needs modernising. All furniture very good condition but from 1980s. Locationwise in residential area. Need to get taxis or public transport to main town square for bars and restaurants (too far to walk) as not much in the local area. Only stayed for 2 nights for the football final. Ideal location to walk to football stadium."
United Kingdom
Paul
Hotel Peko

Charles Bridge Palace

Charles Bridge Palace
4.0 star property
Prague City Center
9.2 out of 10, Wonderful, (1002)
"We enjoyed our stay! The staff were wonderful and the location was amazing."
Australia
Robert
Charles Bridge Palace

Majestic Plaza Hotel Prague

Majestic Plaza Hotel Prague
4.5 star property
Prague City Center
9.0 out of 10, Wonderful, (1090)
"Great hotel,clean rooms ,delicious breakfast.Close to many amenities "
United States
Ana
The price is 1.794.085 ₫
2.137.048 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Majestic Plaza Hotel Prague

Michelangelo Grand Hotel Prague

Michelangelo Grand Hotel Prague
5.0 star property
Prague City Center
9.4 out of 10, Exceptional, (3118)
"Great location, lovely hotel "
United Kingdom
Sally Louise
Michelangelo Grand Hotel Prague

Courtyard by Marriott Prague Airport

Courtyard by Marriott Prague Airport
4.0 star property
Prague 6
9.2 out of 10, Wonderful, (1003)
"Very convenient and comfortable stay by the airport. "
United States
Stephanie
The price is 3.528.646 ₫
4.079.817 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Courtyard by Marriott Prague Airport

Holiday Inn Prague Airport by IHG

Holiday Inn Prague Airport by IHG
4.0 star property
Prague 6
8.8 out of 10, Excellent, (1001)
"The room was clean and breakfast was good "
United States
Kest
The price is 2.625.141 ₫
3.067.400 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
Holiday Inn Prague Airport by IHG

Vienna House by Wyndham Diplomat Prague

Vienna House by Wyndham Diplomat Prague
4.5 star property
Prague 6
9.2 out of 10, Wonderful, (564)
"Great hotel. We have stayed here often when we are in Prague. "
United States
jim
The price is 2.512.700 ₫
2.941.564 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Vienna House by Wyndham Diplomat Prague
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Prague 10 Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

Why book your business-friendly hotel in Prague 10 with Expedia?
Expedia will help you find a fantastic business-friendly hotel when work takes you on the road. From conference spaces and room service to gyms and on-site restaurants, our stays have all the amenities you'll need to close that big deal.
How can I find cheap business-friendly hotels in Prague 10?
When work takes you to Prague 10, our "business friendly" filter will help you find the ideal hotel. From WiFi to meeting rooms and work desks, they have the amenities you need to be productive. Another handy tip? Narrow your search by your budget and preferred star rating to view the cheapest stays.