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Check availability on Prague 2 Business Hotels

Our top choices for Prague 2 business-friendly hotels

Reception
THE MANES Boutique Hotel Prague

THE MANES Boutique Hotel Prague

THE MANES Boutique Hotel Prague
4.0 star property
Nové Město
10.0 out of 10, Exceptional, (316)
"Lovely room, great location, friendly staff. All fantastic"
United Kingdom
Scott
THE MANES Boutique Hotel Prague
Coffee/tea maker, electric kettle
1. Republic Hotel

1. Republic Hotel

1. Republic Hotel
3.5 star property
Nové Město
8.8 out of 10, Excellent, (383)
"Quality-price, a very good option. Good location. Clean. Excellent breakfast. "
Canada
Guy
1. Republic Hotel
Flat-screen TV
DownTown Suites Jugoslavska

DownTown Suites Jugoslavska

DownTown Suites Jugoslavska
4.0 star property
Prague 2
9.4 out of 10, Exceptional, (285)
"Great location "
United States
Satish
The price is 9.081.521 ₫
10.294.966 ₫ total
includes taxes & fees
20 Dec - 21 Dec
DownTown Suites Jugoslavska
Reception
Anyday Apartments

Anyday Apartments

Anyday Apartments
3.0 star property
Nové Město
8.8 out of 10, Excellent, (144)
"The property location was great. There was road construction out front, but it did not impact our stay or our opinions. We will definitely stay here again if we ever return to Prague. Love this country!"
United States
Michael Joel
Anyday Apartments
Lobby
Hotel Galileo Prague

Hotel Galileo Prague

Hotel Galileo Prague
4.0 star property
Prague 2
8.8 out of 10, Excellent, (1002)
"Good hotel, friendly staff "
United Kingdom
robert
Hotel Galileo Prague
Exterior
Le Palais Art Hotel Prague

Le Palais Art Hotel Prague

Le Palais Art Hotel Prague
5.0 star property
Prague 2
9.4 out of 10, Exceptional, (644)
"Lovely staff and facilities will definitely be recommending "
United Kingdom
Sam
The price is 2.107.283 ₫
2.487.949 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Le Palais Art Hotel Prague
Exterior
Mosaic House Design Hotel

Mosaic House Design Hotel

Mosaic House Design Hotel
4.0 star property
Nové Město
9.8 out of 10, Exceptional, (717)
"Stupendous hotel, staff, attention to detail, the lot."
United Kingdom
Patricia
Mosaic House Design Hotel
Bar (on property)
Radisson Blu Hotel, Prague

Radisson Blu Hotel, Prague

Radisson Blu Hotel, Prague
5.0 star property
Nové Město
9.0 out of 10, Wonderful, (506)
"Excellent services, well trained staff."
United States
TETIANA
The price is 3.073.789 ₫
3.569.352 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Radisson Blu Hotel, Prague
Exterior
Mamaison Residence Belgicka

Mamaison Residence Belgicka

Mamaison Residence Belgicka
4.0 star property
Prague 2
9.4 out of 10, Exceptional, (311)
"I like this hotel and I will be back)"
United States
Dmytro
Mamaison Residence Belgicka
Restaurant
Hotel Beranek Prague

Hotel Beranek Prague

Hotel Beranek Prague
3.0 star property
Prague 2
8.2 out of 10, Very good, (137)
"Clean, centrally located, great breakfast."
United States
Natalya
The price is 1.858.350 ₫
2.208.008 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Hotel Beranek Prague
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Prague 2 Hotel Reviews

Hotel Unique

Hotel Unique

10/10 Excellent
"This is an exceptional property in an ideal location in Prague. Fantastic restaurants and the National Museum are just a short walk away and the metro/transit connections are easy across the entire city. The affordable price point, clean and spacious rooms, and helpful staff are also a huge plus. I’ve lived in Prague and also visited the city many times for shorter stays, and this is by far the best hotel option."
Todd 2-night trip
Posted 2 weeks ago
Hotel Unique

Frequently asked questions

Why book your business-friendly hotel in Prague 2 with Expedia?
Expedia will help you find an ideal business-friendly hotel for your upcoming work trip. From conference spaces and room service to on-site restaurants and more, our stays come with the conveniences you'll need to get the job done.
How can I find cheap business-friendly hotels in Prague 2?
Expedia can help you narrow down your search for cheap business-friendly hotels in Prague 2. Simply go to the "traveller experience" filter and click on "business friendly." This will show you stays with amenities designed to help you work comfortably and effectively, like free WiFi and included breakfast. You can also choose your preferred star rating and budget to keep costs within your price range.

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