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11 Dec - 12 Dec
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12 Dec - 13 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Puerto Santa Ana hotels

Outdoor pool
River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
8.6 out of 10, Excellent, (42)
"The staff were soo nice with me and my family !! I really enjoy my stay :)"
United States
Maria
The price is 2.108.953 ₫
2.135.282 ₫ total
26 Dec - 27 Dec
River View suites Puerto Santa Ana gye
Outdoor spa tub
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (100)
"The apartment was in a great location and very clean and well maintained."
United States
Rolando
The price is 2.913.450 ₫
2.939.807 ₫ total
22 Dec - 23 Dec
Luxury Suites Riverfront GYE
2 bars/lounges, lobby lounge
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.2 out of 10, Wonderful, (1000)
"The hotel and service were great!"
United States
Rolando
The price is 2.902.772 ₫
3.259.003 ₫ total
19 Dec - 20 Dec
Wyndham Guayaquil Puerto Santa Ana
Classic Double Room | Free WiFi
Pachamac House

Pachamac House

Pachamac House
2.0 star property
2.9 km from Puerto Santa Ana
The price is 526.580 ₫
526.580 ₫ total
21 Dec - 22 Dec
Pachamac House
Economy Double Room | In-room safe, free WiFi
Malecon Guesthouse

Malecon Guesthouse

Malecon Guesthouse
3.0 star property
1 km from Puerto Santa Ana
The price is 368.606 ₫
658.225 ₫ total
26 Dec - 27 Dec
Malecon Guesthouse
Terrace/patio
Villa Celeste - VC

Villa Celeste - VC

Villa Celeste - VC
2.5 star property
4.9 km from Puerto Santa Ana
7.2 out of 10, Good, (12)
"It is a good place, they respect your privacity and has a good communication with tourist places "
Mexico
Moises Reque
The price is 417.051 ₫
417.051 ₫ total
26 Dec - 27 Dec
Villa Celeste - VC
Exterior
Hotel La Ria Durán

Hotel La Ria Durán

Hotel La Ria Durán
3.0 star property
3.3 km from Puerto Santa Ana
7.2 out of 10, Good, (19)
"Muy buena experiencia"
Ecuador
HERNAN
The price is 1.263.792 ₫
1.263.792 ₫ total
26 Dec - 27 Dec
Hotel La Ria Durán
Restaurant
Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (2)
"The staff was very friendly and helpful. The hotel is new and modern, it is a good place to relax and work. "
United States
Richard
The price is 6.583.188 ₫
7.353.603 ₫ total
17 Dec - 18 Dec
Hotel Río Guayas by Art Hotels Ecuador
Ecotours
Fortune Hotel

Fortune Hotel

Fortune Hotel
3.0 star property
1 km from Puerto Santa Ana
8.0 out of 10, Very good, (7)
"Very bad Hotel. Not using Expedia again. "
United States
Bryan
The price is 1.184.805 ₫
1.211.134 ₫ total
11 Jan - 12 Jan 2026
Fortune Hotel
Property grounds
Hostal Macaw

Hostal Macaw

Hostal Macaw
3.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (9)
"Wonderful hosts and felt like home "
United States
Tina
The price is 1.839.344 ₫
1.865.673 ₫ total
11 Jan - 12 Jan 2026
Hostal Macaw
Reception
Hostal California Inn

Hostal California Inn

Hostal California Inn
3.0 star property
1.5 km from Puerto Santa Ana
8.6 out of 10, Excellent, (8)
"Me encantó, es muy cómoda, la habitación super amplia y limpia Si duda volveré "
Mexico
Anita
Hostal California Inn
Terrace/patio
Hotel del Parque

Hotel del Parque

Hotel del Parque
4.5 star property
3.6 km from Puerto Santa Ana
9.8 out of 10, Exceptional, (106)
"I love"
United States
Maria
The price is 11.307.153 ₫
12.437.868 ₫ total
29 Dec - 30 Dec
Hotel del Parque
Executive Suite, Kitchenette, City View | Private kitchen | Microwave, electric kettle, griddle, cookware/dishes/utensils
Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil

Suitesecu Rentals Guayaquil
4.5 star property
Simón Bolívar, 3.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (7)
"You can walk to the airport."
United States
Digna
The price is 699.779 ₫
871.100 ₫ total
22 Dec - 23 Dec
Suitesecu Rentals Guayaquil
Honeymoon Double Room | Minibar, desk, laptop workspace, free WiFi
HOTEL PERLA CENTRAL MALECON

HOTEL PERLA CENTRAL MALECON

HOTEL PERLA CENTRAL MALECON
2.5 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
7.6 out of 10, Good, (18)
"Balcony view was very cool "
United States
Julio
The price is 829.363 ₫
829.363 ₫ total
26 Dec - 27 Dec
HOTEL PERLA CENTRAL MALECON
Lobby lounge
Mansión del Río

Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (133)
"Older but beautiful building. Very nice rooms. Good location. "
United States
Matthew
The price is 1.563.943 ₫
1.746.666 ₫ total
15 Dec - 16 Dec
Mansión del Río
Front of property – evening/night
Guayaquil Hostel Suites Madrid

Guayaquil Hostel Suites Madrid

Guayaquil Hostel Suites Madrid
3.5 star property
1.7 km from Puerto Santa Ana
7.2 out of 10, Good, (32)
"noisy and dark but friendly staff central location"
Germany
Anonymous traveller
The price is 975.209 ₫
1.001.566 ₫ total
13 Dec - 14 Dec
Guayaquil Hostel Suites Madrid
Lobby sitting area
Casa Veranda

Casa Veranda

Casa Veranda
2.5 star property
12.9 km from Puerto Santa Ana
Casa Veranda
Comfort Apartment, Kitchenette
Guayacan Apart Hotel

Guayacan Apart Hotel

Guayacan Apart Hotel
2.0 star property
Downtown Guayaquil, 1.6 km from Puerto Santa Ana
The price is 1.053.160 ₫
1.053.160 ₫ total
26 Dec - 27 Dec
Guayacan Apart Hotel
32-inch Smart TV with digital channels, first-run films
Departamentos en la Garzota

Departamentos en la Garzota

Departamentos en la Garzota
4.5 star property
Garzota, 4 km from Puerto Santa Ana
The price is 789.870 ₫
829.364 ₫ total
8 Jan - 9 Jan 2026
Departamentos en la Garzota
Gym
Hotel Cityzen Guayaquil

Hotel Cityzen Guayaquil

Hotel Cityzen Guayaquil
3.0 star property
1.6 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (37)
"Was nice "
United States
Joe
Hotel Cityzen Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas for the activities you enjoy most.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Garzota

The restaurants and shopping are a few reasons travellers visit Garzota. Though there aren't many top sights in the neighbourhood, you can visit Mall del Sol Shopping Center and Plaza del Sol, a few notable attractions nearby.

Top Puerto Santa Ana Hotel Reviews

Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil

10/10 Excellent
"Everything worked perfectly. The air conditioner kept the temp all night. The bathroom was large and clean. All staff was friendly. We enjoyed our food and drinks on the rooftop when we arrived. "
Heather 1-night trip
Posted 2 months ago
Doubletree By Hilton Guayaquil
Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport

10/10 Excellent
"I didn't eat breakfast. Overall my stay was excellent. Had staff meet me at airport and take me to the hotel. Check-in was very quick. Found the room to be spacious, very clean, and the bathroom was well stocked with the shower necessities. Was very pleased with my stay and highly recommend the hotel."
Joe 1-night trip
Posted 2 months ago
Hotel Puerto Pacifico Guayaquil Airport

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Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighbourhood that travellers like for its restaurants and sporting events.
How many hotels should I expect to find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 81 Puerto Santa Ana hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to view the best deals in Puerto Santa Ana.
What is there to do around this Guayaquil neighbourhood?
Emporium by The Point, Santa Ana Garden and Botanical Garden are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Santa Ana Hill and Numa Pompilio Llona Street are a couple of additional sights to visit in Guayaquil.