Search Hotels in Puerto Santa Ana, Guayaquil

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
9 Dec - 10 Dec
Tomorrow
10 Dec - 11 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Puerto Santa Ana hotels

Presidential Suite, 1 King Bed, Jetted Tub, River View | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds
Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana

4.5 star property
Puerto Santa Ana
9.2 out of 10, Wonderful, (1002)
"The hotel and service were great!"
United States
Rolando
The price is 2.906.411 ₫
3.263.089 ₫ total
13 Dec - 14 Dec
Wyndham Guayaquil Puerto Santa Ana
Outdoor pool
River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye

3.0 star property
Puerto Santa Ana
8.6 out of 10, Excellent, (42)
"The staff were soo nice with me and my family !! I really enjoy my stay :)"
United States
Maria
The price is 2.111.596 ₫
2.137.958 ₫ total
10 Dec - 11 Dec
River View suites Puerto Santa Ana gye
43-inch flat-screen TV with digital channels, TV, Netflix
Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE

3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (100)
"The apartment was in a great location and very clean and well maintained."
United States
Rolando
The price is 2.914.003 ₫
2.940.365 ₫ total
20 Dec - 21 Dec
Luxury Suites Riverfront GYE
Rooftop bar, al fresco dining, open daily
Wyndham Garden Guayaquil

Wyndham Garden Guayaquil

3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1000)
"Airport shuttle was very convenient "
Canada
Arlene
The price is 2.174.865 ₫
2.431.895 ₫ total
13 Dec - 14 Dec
Wyndham Garden Guayaquil
Outdoor pool
Holiday Inn Guayaquil Airport by IHG

Holiday Inn Guayaquil Airport by IHG

3.5 star property
3.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1009)
"Great stay"
United States
Susan
The price is 2.214.408 ₫
2.501.754 ₫ total
23 Dec - 24 Dec
Holiday Inn Guayaquil Airport by IHG
2 restaurants, breakfast, lunch, dinner served; Regional cuisine
Sheraton Guayaquil Hotel

Sheraton Guayaquil Hotel

5.0 star property
Simón Bolívar, 2.9 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (605)
"Very friendly front desk thank you for a comfortable and enjoyable stay. "
United States
Andrew
The price is 2.844.196 ₫
3.194.521 ₫ total
19 Dec - 20 Dec
Sheraton Guayaquil Hotel
Lobby
Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil

3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1004)
"Great stay and they were able to accommodate our last minute booking. We had an amazing view of the city and the room was spotless."
United States
Cesar
The price is 1.898.064 ₫
2.127.414 ₫ total
26 Dec - 27 Dec
Courtyard by Marriott Guayaquil
Outdoor pool, pool loungers
Radisson Hotel Guayaquil

Radisson Hotel Guayaquil

5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (631)
"Good service "
United States
Genny
The price is 2.520.998 ₫
2.839.003 ₫ total
19 Dec - 20 Dec
Radisson Hotel Guayaquil
Children’s activities
Oro Verde Guayaquil

Oro Verde Guayaquil

5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (1009)
"Very good stay , recommend 100%"
United States
Lenin
The price is 2.346.218 ₫
2.646.745 ₫ total
16 Dec - 17 Dec
Oro Verde Guayaquil
Outdoor pool, open 8:00 AM to 9:00 PM, pool loungers
Grand Hotel Guayaquil, an Ascend Collection Hotel

Grand Hotel Guayaquil, an Ascend Collection Hotel

4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (986)
"Great place to Stay.!"
United States
Erwin
The price is 2.372.580 ₫
2.649.381 ₫ total
20 Dec - 21 Dec
Grand Hotel Guayaquil, an Ascend Collection Hotel
Exterior
TRYP by Wyndham Guayaquil Airport

TRYP by Wyndham Guayaquil Airport

4.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1004)
"💯"
United States
Sreenidhi
The price is 2.510.981 ₫
2.828.116 ₫ total
14 Dec - 15 Dec
TRYP by Wyndham Guayaquil Airport
Lobby
Hilton Colon Guayaquil

Hilton Colon Guayaquil

4.5 star property
Kennedy, 3.2 km from Puerto Santa Ana
8.6 out of 10, Excellent, (812)
"Great room"
United States
Trevor
The price is 2.485.937 ₫
2.800.436 ₫ total
20 Dec - 21 Dec
Hilton Colon Guayaquil
Exterior
Hotel GH Galeria

Hotel GH Galeria

3.5 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
8.4 out of 10, Very good, (392)
"Muy caro para lo que ofrece y el buffet no hay variedad "
Mexico
GUIDO
Hotel GH Galeria
Reception
Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels

4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1002)
"Nice place to stay"
United States
Victor
The price is 1.803.229 ₫
2.049.460 ₫ total
7 Jan - 8 Jan 2026
Unipark by Oro Verde Hotels
Restaurant
Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil

4.0 star property
Downtown Guayaquil, 1.6 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (272)
"Great location and great hotel "
United States
José
The price is 1.581.720 ₫
1.779.435 ₫ total
12 Dec - 13 Dec
Ibis Styles El Malecon Guayaquil
Lobby
DC Suites Aeropuerto

DC Suites Aeropuerto

3.0 star property
Simón Bolívar, 3 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (578)
"Great location and clean hotel"
United States
Elvin
DC Suites Aeropuerto
Outdoor pool, pool loungers
Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield

3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.6 out of 10, Excellent, (132)
"Excellent location and close to the airport."
United States
Martin Gerardo
Hotel Patrimonial by Greenfield
Lobby
Hotel Palace Guayaquil

Hotel Palace Guayaquil

4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (911)
"Good place to stay "
United States
GIOVANNY
The price is 1.601.491 ₫
1.801.183 ₫ total
13 Dec - 14 Dec
Hotel Palace Guayaquil
In-room safe, blackout curtains, soundproofing, iron/ironing board
Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil

3.5 star property
Rocafuerte, 1.8 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (71)
"We stayed here twice and both the times to staff was excellent, the property was centrally located, it felt safe, and welcoming. I highly recommend this hotel and felt like it exceeded our expectations."
United States
Ravi
The price is 1.838.711 ₫
2.352.371 ₫ total
5 Jan - 6 Jan 2026
Doubletree By Hilton Guayaquil
Garden
Dreamkapture Hostel

Dreamkapture Hostel

2.0 star property
Alborada, 5.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (19)
"Good Pool !"
Australia
Julie
Dreamkapture Hostel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas for the activities you enjoy most.

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like San Francisco Square and Central Market while you're in town.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

Garzota

The restaurants and shopping are a few reasons travellers visit Garzota. Though there aren't many top sights in the neighbourhood, you can visit Mall del Sol Shopping Center and Plaza del Sol, a few notable attractions nearby.

Top Puerto Santa Ana Hotel Reviews

Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil

10/10 Excellent
"Everything worked perfectly. The air conditioner kept the temp all night. The bathroom was large and clean. All staff was friendly. We enjoyed our food and drinks on the rooftop when we arrived. "
Heather 1-night trip
Posted 2 months ago
Doubletree By Hilton Guayaquil
Hotel Puerto Pacifico Guayaquil Airport

Hotel Puerto Pacifico Guayaquil Airport

10/10 Excellent
"I didn't eat breakfast. Overall my stay was excellent. Had staff meet me at airport and take me to the hotel. Check-in was very quick. Found the room to be spacious, very clean, and the bathroom was well stocked with the shower necessities. Was very pleased with my stay and highly recommend the hotel."
Joe 1-night trip
Posted 2 months ago
Hotel Puerto Pacifico Guayaquil Airport

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighbourhood that travellers like for its restaurants and sporting events.
How many hotels should I expect to find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 81 Puerto Santa Ana hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to view the best deals in Puerto Santa Ana.
What is there to do around this Guayaquil neighbourhood?
Emporium by The Point, Santa Ana Garden and Botanical Garden are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Santa Ana Hill and Numa Pompilio Llona Street are a couple of additional sights to visit in Guayaquil.