Search Hotels in Sanctuary On Spruce Creek, Port Orange

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
10 Dec - 11 Dec
Tomorrow
11 Dec - 12 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Sanctuary On Spruce Creek hotels

Exterior
Holiday Inn Express & Suites Deland South by IHG

Holiday Inn Express & Suites Deland South by IHG

2.5 star property
27.7 km from Sanctuary On Spruce Creek
9.2 out of 10, Wonderful, (693)
"Great stay, Great Breakfast, Great Staff. "
United States
Javier
The price is 2.267.132 ₫
2.550.524 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Deland South by IHG
Exterior
Comfort Inn & Suites DeLand - near University

Comfort Inn & Suites DeLand - near University

2.5 star property
25.8 km from Sanctuary On Spruce Creek
8.4 out of 10, Very good, (1005)
"Nice staff food was good. It was pleasant. Would recommend it. "
United States
Camilla and James
The price is 2.106.324 ₫
2.369.614 ₫ total
includes taxes & fees
29 Dec - 30 Dec
Comfort Inn & Suites DeLand - near University
Exterior
Daytona Grande Oceanfront Resort

Daytona Grande Oceanfront Resort

4.0 star property
17 km from Sanctuary On Spruce Creek
9.2 out of 10, Wonderful, (4200)
"Wonderful place to stay "
United States
Stacey
The price is 2.931.454 ₫
4.187.604 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Daytona Grande Oceanfront Resort
Terrace/patio
Courtyard by Marriott DeLand Historic Downtown

Courtyard by Marriott DeLand Historic Downtown

3.0 star property
26.8 km from Sanctuary On Spruce Creek
8.8 out of 10, Excellent, (713)
"Clean and kind! "
United States
Elizabeth
The price is 2.662.562 ₫
2.995.382 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott DeLand Historic Downtown
View from property
Coral Sands Inn

Coral Sands Inn

2.5 star property
26.1 km from Sanctuary On Spruce Creek
9.4 out of 10, Exceptional, (1269)
"Very nice stay."
United States
Alberto
The price is 2.349.567 ₫
2.643.263 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Coral Sands Inn
Lobby
Quality Inn near Blue Spring

Quality Inn near Blue Spring

2.5 star property
30 km from Sanctuary On Spruce Creek
7.2 out of 10, Good, (932)
"Room was actually not that bad. Looks like they have recently put new floors (not carpet) which is always a bonus at motels. New paint and the bed wasn’t bad either. For the price it was right there on point, for the experience which was nothing special. If you’re looking for a decent motel that’s not too ghetto then it will do. "
United States
Beau
The price is 2.135.322 ₫
2.402.238 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Quality Inn near Blue Spring
Front of property
Holiday Inn Express & Suites Orange City - Deltona by IHG

Holiday Inn Express & Suites Orange City - Deltona by IHG

2.5 star property
30.3 km from Sanctuary On Spruce Creek
9.0 out of 10, Wonderful, (1001)
"It was a great place to stay at"
United States
Luis
The price is 2.373.300 ₫
2.669.962 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Holiday Inn Express & Suites Orange City - Deltona by IHG
Outdoor pool
Days Inn by Wyndham Daytona Oceanfront

Days Inn by Wyndham Daytona Oceanfront

2.5 star property
10 km from Sanctuary On Spruce Creek
8.6 out of 10, Excellent, (1939)
"Everyone is super friendly great place to stay and relax"
United States
Liss
The price is 2.017.305 ₫
2.506.534 ₫ total
includes taxes & fees
18 Dec - 19 Dec
Days Inn by Wyndham Daytona Oceanfront
2 outdoor pools, pool umbrellas, pool loungers
Hilton Daytona Beach Oceanfront Resort

Hilton Daytona Beach Oceanfront Resort

4.0 star property
16.5 km from Sanctuary On Spruce Creek
7.4 out of 10, Good, (5001)
"Really enjoyed my stay."
United States
Stephano
The price is 2.576.885 ₫
3.640.559 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hilton Daytona Beach Oceanfront Resort
Premium bedding, pillow-top beds, desk, laptop workspace
Lotus Boutique Inn & Suites

Lotus Boutique Inn & Suites

3.0 star property
21.9 km from Sanctuary On Spruce Creek
7.6 out of 10, Good, (1391)
"Absolutely love this place… I will definitely be returning in the Spring!"
United States
Jeanne
The price is 1.874.338 ₫
2.108.631 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Lotus Boutique Inn & Suites
Free daily on-the-go breakfast
Extended Stay America Premier Suites Daytona Beach Ormond Be

Extended Stay America Premier Suites Daytona Beach Ormond Be

2.5 star property
20.7 km from Sanctuary On Spruce Creek
8.6 out of 10, Excellent, (1003)
"Nice property friendly staff"
United States
Shanna
The price is 1.945.252 ₫
2.188.310 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Extended Stay America Premier Suites Daytona Beach Ormond Be
Room, 1 King Bed, Accessible, Non Smoking | Down duvets, in-room safe, desk, laptop workspace
Clarion Inn Ormond Beach at Destination Daytona

Clarion Inn Ormond Beach at Destination Daytona

2.5 star property
30.1 km from Sanctuary On Spruce Creek
8.2 out of 10, Very good, (922)
"clean, well-staffed, friendly, helpful, close to dining options, safe"
United States
Jan
The price is 2.218.362 ₫
2.495.658 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Clarion Inn Ormond Beach at Destination Daytona
Desk, blackout curtains, iron/ironing board, free cots/infant beds
Super 8 by Wyndham Ormond Beach

Super 8 by Wyndham Ormond Beach

2.0 star property
30 km from Sanctuary On Spruce Creek
7.2 out of 10, Good, (1001)
"Super 8 was clean, comfortable, and despite being near the interstate (convenient) was pretty quiet. Many food options nearby. Staff was friendly and responsive to my questions. Definitely recommend for a low cost hotel"
United States
Catherine
The price is 1.766.254 ₫
1.987.035 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Super 8 by Wyndham Ormond Beach
Indoor pool, outdoor pool, pool umbrellas, pool loungers
Hilton Vacation Club The Cove on Ormond Beach

Hilton Vacation Club The Cove on Ormond Beach

3.0 star property
22.9 km from Sanctuary On Spruce Creek
9.0 out of 10, Wonderful, (1005)
"This was one of my fave resorts in Daytona Beach. Beautiful water front views, nice staffs, clean, quiet, easy parking. I felt very comfortable and convenient when I stayed. "
United States
Enyi
The price is 2.473.810 ₫
3.524.598 ₫ total
includes taxes & fees
12 Dec - 13 Dec
Hilton Vacation Club The Cove on Ormond Beach
Front of property – evening/night
Sleep Inn Ormond Beach - Daytona

Sleep Inn Ormond Beach - Daytona

2.5 star property
20.8 km from Sanctuary On Spruce Creek
7.6 out of 10, Good, (1006)
"Staff is very nice."
United States
Jenna
The price is 1.358.406 ₫
1.646.538 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Sleep Inn Ormond Beach - Daytona
View from property
Nautilus Inn

Nautilus Inn

2.5 star property
14.4 km from Sanctuary On Spruce Creek
9.2 out of 10, Wonderful, (3029)
"Friendly staff, clean room"
United States
Kent
The price is 2.491.209 ₫
2.802.610 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Nautilus Inn
Terrace/patio
Home2 Suites by Hilton Ormond Beach Oceanfront

Home2 Suites by Hilton Ormond Beach Oceanfront

3.0 star property
21.3 km from Sanctuary On Spruce Creek
9.2 out of 10, Wonderful, (990)
"Love the place, it was family friendly "
United States
Andy
The price is 3.142.350 ₫
3.535.143 ₫ total
includes taxes & fees
17 Dec - 18 Dec
Home2 Suites by Hilton Ormond Beach Oceanfront
2 outdoor pools, a heated pool, pool umbrellas, pool loungers
Hard Rock Hotel Daytona Beach

Hard Rock Hotel Daytona Beach

4.0 star property
17.8 km from Sanctuary On Spruce Creek
9.2 out of 10, Wonderful, (1624)
"Excellent service from the entire staff, we had a great stay."
United States
Joshua
The price is 3.712.824 ₫
5.205.358 ₫ total
includes taxes & fees
11 Dec - 12 Dec
Hard Rock Hotel Daytona Beach
Outdoor pool
Comfort Inn & Suites Ormond Beach Oceanfront

Comfort Inn & Suites Ormond Beach Oceanfront

2.5 star property
22.5 km from Sanctuary On Spruce Creek
8.0 out of 10, Very good, (746)
"Everything was good and clean. Courteous and friendly staff"
United States
Jasmine
The price is 2.330.401 ₫
2.621.702 ₫ total
includes taxes & fees
14 Dec - 15 Dec
Comfort Inn & Suites Ormond Beach Oceanfront
2 Bedroom Ocean & City South View Residence | Terrace/patio
Max Beach Resort

Max Beach Resort

3.5 star property
14.1 km from Sanctuary On Spruce Creek
9.6 out of 10, Exceptional, (916)
"My favorite place to stay in Daytona!"
United States
Justin
Max Beach Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Sanctuary On Spruce Creek

Find the best Sanctuary On Spruce Creek areas for the activities you enjoy most.

Carter Norwood

While Carter Norwood may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Ponce de Leon Inlet Lighthouse and Museum and Sunglow Fishing Pier.

Halifax Estates

When in Halifax Estates, you can plan a visit to Ponce de Leon Inlet Lighthouse and Museum and Sunglow Fishing Pier, some noteworthy sights in the nearby area.

Winthrop Holding

Though Winthrop Holding may not have many top sights, you can venture to the surrounding area to see attractions like Sunglow Fishing Pier and Ponce de Leon Inlet Lighthouse and Museum.

Fly In Spruce Creek

While Fly In Spruce Creek isn't home to many top sights, Spruce Creek Country Club and Crane Lakes Golf and Country Club are some notable places to visit nearby.

Spruce Creek

While there might not be top attractions in Spruce Creek, you can explore the larger area and discover places like Spruce Creek Country Club and Airport Road Park.

Top Sanctuary On Spruce Creek Hotel Reviews

Explore a world of travel with Expedia

Frequently asked questions

What is Sanctuary On Spruce Creek like?
Travellers to the Sanctuary On Spruce Creek neighbourhood in Port Orange will be sure to enjoy their stay.
If I need to cancel my hotel reservation in Sanctuary On Spruce Creek, will I receive a refund?
Yes, you'll find most hotel room reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of check in. If you have a non-refundable reservation, you might be able to cancel it and get a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to review the best deals available in Sanctuary On Spruce Creek.
What is there to do in this Port Orange neighbourhood?
Gamble Place, Spruce Creek Country Club and Airport Road Park are just a few of the places to visit in and around Sanctuary On Spruce Creek. Golf Club at Cypress Head and Crane Lakes Golf and Country Club are also worth a visit when you're out sightseeing in Port Orange.