Search Luxury Hotels in Sanibel

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Sanibel Luxury Hotels

Tonight
22 Dec - 23 Dec
Tomorrow
23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

Our top choices for Sanibel luxury hotels

2 outdoor pools, pool cabanas (surcharge), pool umbrellas
Sundial Beach Resort & Spa

Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island
8.6 out of 10, Excellent, (2584)
"wonderful family friendly and spotless resort"
United States
Mary Anne
The price is 10.160.221 ₫
12.766.366 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Sundial Beach Resort & Spa
Outdoor pool, pool umbrellas, pool loungers
Seaside Inn

Seaside Inn

Seaside Inn
3.5 star property
East End
8.8 out of 10, Excellent, (1001)
"Was a wonferful stay."
United States
Jennifer
Seaside Inn
View from room
Sunset Beach Inn

Sunset Beach Inn

Sunset Beach Inn
2.0 star property
West End
8.2 out of 10, Very good, (1000)
"Quiet location and friendly staff"
United States
Johnell
Sunset Beach Inn
Bicycling
Anchor Inn and Cottages

Anchor Inn and Cottages

Anchor Inn and Cottages
2.5 star property
Mid Island
8.6 out of 10, Excellent, (606)
"A fun place to stay on a beautiful island!"
United States
Susan
Anchor Inn and Cottages
Outdoor pool, a heated pool
West Wind Inn

West Wind Inn

West Wind Inn
3.0 star property
West End
8.8 out of 10, Excellent, (1000)
"close access to the beach."
United States
Kevin
West Wind Inn
Exterior
Kona Kai Motel

Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island
9.0 out of 10, Wonderful, (941)
"Spacious rooms, friendly staff, quiet surroundings."
United States
James
Kona Kai Motel
Exterior
Sanibel Inn

Sanibel Inn

Sanibel Inn
3.0 star property
East End
9.0 out of 10, Wonderful, (1000)
"Very nice hotel/resort. Clean, quiet, nice pool, attentive staff. Love the screened in balcony. "
Canada
Jonathan
The price is 9.279.621 ₫
11.872.521 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Sanibel Inn
Luxury Suite, Sea View | Beach/ocean view
Island Inn

Island Inn

Island Inn
3.5 star property
West End
9.4 out of 10, Exceptional, (1122)
"Really nice, updated, and clean room with a screened waterfront balcony in a perfect place on the island (far enough away from the big resorts to be in a quieter area, but close enough to the center area of the island to be convenient). "
United States
Chris
The price is 6.815.585 ₫
7.599.376 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Island Inn
On the beach, sun-loungers, beach umbrellas, fishing
Gulf Breeze Cottages

Gulf Breeze Cottages

Gulf Breeze Cottages
2.0 star property
Mid Island
9.4 out of 10, Exceptional, (197)
"Lovely, would certainly stay again, thank you, Gulf Breeze Cottages!"
United States
Regina G
Gulf Breeze Cottages
Outdoor pool
Casa Ybel Resort

Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Mid Island
8.8 out of 10, Excellent, (290)
"Room was amazing! Their video on their site is pre Hurricane Ian so don’t expect it to be like that ! Lots of devistation but they are working to bring it back. Most staff was nice , the front office staff were snotty and not helpful at !! Location on the beach is amazing! Sanibel / Captiva have captured my heart and I can’t wait to return. I’d stay there again . "
United States
Arra
The price is 13.657.485 ₫
15.228.227 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Casa Ybel Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Sanibel Hotel Reviews

Kona Kai Motel

Kona Kai Motel

10/10 Excellent
" very clean"
ROBERT B 2-night trip
Posted 12 days ago
Kona Kai Motel

Frequently asked questions

Are you looking for a luxury hotel for your stay in Sanibel?
Use Expedia and let us help you arrange a flight to Fort Myers, FL (RSW-Southwest Florida Intl.) airport or Punta Gorda Airport (PGD) airport, and then select from different places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to find what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with a spa, an indoor pool or luxury bedding, Expedia can help you find the best luxury hotel experience that Sanibel offers. During your visit, you might want to enjoy the beaches and sunsets which Sanibel is known for.
When can I expect good weather in Sanibel?
Planning for the weather is an important factor for making your trip to Sanibel a success, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 28°C, while the coldest months are January and February, with an average of 20°C. The rainiest months in Sanibel are August, September, July and June, with each month seeing an average of 219 mm of rainfall.
What's there to see and do in Sanibel?
Enjoy all that Sanibel has to offer when you visit Sanibel Island Northern Beach, Sanibel Island Lighthouse and Periwinkle Way. If you have a little extra time during your trip, you might want to check out Sanibel Island Southern Beach and J. N. Ding Darling National Wildlife Refuge.