A white colonial church with ornate architecture and a large wooden door.

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Check prices for these dates

This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for Santa Ana hotels

A two-story building with yellow walls, a balcony with purple flowers, and multiple windows with metal bars.

1. Villas Santa Ana-Ricardo

Villas Santa Ana-Ricardo
3.5 star property
Santa Ana
9.0 out of 10, Wonderful, (17 reviews)
"Beautiful place to stay at!"
United States
Nery
The price is 2.623.414 ₫
3.200.565 ₫ total
includes taxes & fees
16 Oct - 17 Oct
Villas Santa Ana-Ricardo
A lush garden with neatly trimmed hedges forming a pathway, surrounded by dense greenery and a mountainous backdrop.

2. Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.6 out of 10, Excellent, (26 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is 1.012.674 ₫
1.235.462 ₫ total
includes taxes & fees
21 Oct - 22 Oct
Hostal Casa Buho
A rooftop with a red roof, a white railing, and a view of a mountainous landscape.

3. Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is 343.730 ₫
735.245 ₫ total
includes taxes & fees
16 Oct - 17 Oct
Castillo De Los Gigantes
A restaurant with a brick wall, wine racks, and tables set for dining.

4. Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"The mattress was amazing, the breakfast was really good and there were many choices and the staff were very helpful. I will definitely return back again."
United States
Valeria
The price is 3.923.563 ₫
4.942.105 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Los Pasos Boutique Hotel & Spa
A stone-walled corridor with steps leading to a wooden door, surrounded by lush greenery and potted plants.

5. Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, 1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,173 reviews)
"Great stay. Spa is amazing"
United States
Julio
The price is 6.382.624 ₫
8.102.696 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Hotel Museo Spa Casa Santo Domingo
A cozy room with a round table, striped armchairs, and a potted plant.

6. Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.6 out of 10, Exceptional, (1,000 reviews)
"Beautiful hotel, wonderful and friendly staff, extremely clean and willing to do anything to help. Bonus is that you can exchange currency at the hotel at a much better rate than almost anywhere else. Very close to a lot of things as well"
United States
Jorge
The price is 4.893.777 ₫
6.617.733 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Hotel Camino Real Antigua
A bedroom with a four-poster bed, two armchairs, a desk, and a nightstand.

7. El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (945 reviews)
"Beautiful Hotel."
United States
KEVIN
The price is 6.447.357 ₫
8.254.171 ₫ total
includes taxes & fees
29 Oct - 30 Oct
El Convento Boutique Hotel
A garden pathway leading to a building with a green lawn and a clear blue sky.

8. Hotel Soleil La Antigua

Hotel Soleil La Antigua
4.0 star property
1.8 km from Santa Ana
8.8 out of 10, Excellent, (1,000 reviews)
"Really nice place to stay"
United States
Donny Guyvan Caserez
The price is 4.351.453 ₫
5.308.772 ₫ total
includes taxes & fees
11 Nov - 12 Nov
Hotel Soleil La Antigua
A stone pathway leading to a central fountain, flanked by walls adorned with framed artwork.

9. Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
1.1 km from Santa Ana
9.4 out of 10, Exceptional, (1,000 reviews)
"Beautiful hotel, super friendly staff, great location in the city. 100% recommend"
United Kingdom
Shivani
The price is 5.222.359 ₫
6.371.278 ₫ total
includes taxes & fees
25 Oct - 26 Oct
Porta Hotel Antigua
A spacious courtyard with red chairs and tables, surrounded by lush greenery and potted plants.

10. El Carmen Hotel

El Carmen Hotel
3.0 star property
Historic Center, 1.3 km from Santa Ana
9.0 out of 10, Wonderful, (941 reviews)
"The breakfast and staff are incredible! Great location!"
United States
Jennifer
The price is 1.984.939 ₫
2.421.626 ₫ total
includes taxes & fees
18 Oct - 19 Oct
El Carmen Hotel
A stone building with arched entrances and a balcony with wrought iron railings.

11. Meson Panza Verde

Meson Panza Verde
4.0 star property
1.1 km from Santa Ana
9.2 out of 10, Wonderful, (510 reviews)
"Great place to stay"
United States
Mauricio
The price is 2.978.317 ₫
3.633.547 ₫ total
includes taxes & fees
22 Oct - 23 Oct
Meson Panza Verde
An outdoor patio with stone flooring, wicker furniture, and umbrellas providing shade.

12. Hotel Casa Carmina by AHS

Hotel Casa Carmina by AHS
4.0 star property
1.2 km from Santa Ana
8.8 out of 10, Excellent, (375 reviews)
"Great location, very friendly staff and very clean."
United States
Martha
The price is 1.103.042 ₫
1.345.711 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Hotel Casa Carmina by AHS
A rooftop terrace with outdoor seating, a fire feature, and a view of a mountain.

13. Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 1.4 km from Santa Ana
9.8 out of 10, Exceptional, (284 reviews)
"Beautiful rooms, very attentive staff, and delicious breakfast!"
United States
Miria
The price is 7.282.406 ₫
8.884.665 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Las Cruces Boutique Hotel
A modern, triangular wooden structure with a glass entrance, surrounded by lush greenery.

14. Santo Cielo by Casa Santo Domingo

Santo Cielo by Casa Santo Domingo
3.5 star property
0.9 km from Santa Ana
9.4 out of 10, Exceptional, (575 reviews)
"Great place and staff"
United States
Ricardo
The price is 5.499.673 ₫
7.025.495 ₫ total
includes taxes & fees
16 Oct - 17 Oct
Santo Cielo by Casa Santo Domingo
A corner with two upholstered chairs, a small round table, and a potted plant.

15. Ciel-Luxe Hotels

Ciel-Luxe Hotels
3.5 star property
Historic Center, 1.4 km from Santa Ana
8.8 out of 10, Excellent, (471 reviews)
"Great service and staff"
United States
Jose
The price is 2.196.003 ₫
2.679.123 ₫ total
includes taxes & fees
12 Nov - 13 Nov
Ciel-Luxe Hotels
A covered outdoor area with stone flooring, potted plants, and a wooden pergola.

16. San Rafael Hotel

San Rafael Hotel
4.0 star property
Historic Center, 1.5 km from Santa Ana
9.8 out of 10, Exceptional, (496 reviews)
"We loved it!! The location is great. The room was amazing, the breakfast, the staff… everything was perfect."
Mexico
Francisco Benjamin Macias
The price is 5.360.970 ₫
6.618.062 ₫ total
includes taxes & fees
16 Oct - 17 Oct
San Rafael Hotel
A covered corridor with tiled flooring, potted plants, and a wooden bench.

17. Hotel Las Farolas

Hotel Las Farolas
3.5 star property
1.2 km from Santa Ana
9.2 out of 10, Wonderful, (808 reviews)
"Hotel was conveniently located. But the walls were really thin. We were in front of the restaurant and the main hall so you can hear EVERYTHING and Everyone. Overall ok hotel and convenient location."
United States
Erika
The price is 2.796.444 ₫
3.411.661 ₫ total
includes taxes & fees
19 Oct - 20 Oct
Hotel Las Farolas
A yellow building with a clock tower and an archway.

18. Hotel Convento Santa Catalina

Hotel Convento Santa Catalina
3.5 star property
Historic Center, 1.6 km from Santa Ana
8.2 out of 10, Very good, (667 reviews)
"Great hotel, great location !"
United States
christina
The price is 1.132.559 ₫
1.381.722 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Hotel Convento Santa Catalina
A courtyard with stone walls, a fountain, and various plants and flowers.

19. Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 1.5 km from Santa Ana
9.4 out of 10, Exceptional, (786 reviews)
"Excellent location helps to have short walking distance to all nearby highlights."
United States
jose
The price is 6.473.250 ₫
7.897.365 ₫ total
includes taxes & fees
29 Oct - 30 Oct
Hotel Posada de Don Rodrigo Antigua
An outdoor seating area with tables and chairs, surrounded by a tree and string lights.

20. Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.9 km from Santa Ana
9.6 out of 10, Exceptional, (255 reviews)
"Well run hotel with excellent atmosphere and experience but you can enjoy it because the hotel is spotless clean, well maintain and everthing works to perfection. As an Hotelier you just enjoy to see well run Hotels"
United States
Jose Gonzalez
The price is 2.079.210 ₫
2.536.636 ₫ total
includes taxes & fees
25 Oct - 26 Oct
Casa Noble Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Ana

Find the best Santa Ana areas for the activities you enjoy most.
A historic yellow archway leading to a clock tower, surrounded by old buildings.

Historic Center

If you're spending some time in Historic Center, Central Park and Santa Catalina Arch are top sights worth seeing.

A town with a prominent volcano in the background.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

InterContinental Real Guatemala by IHG

InterContinental Real Guatemala by IHG

10/10 Excellent
"Todos son súper atentos y amables. Nos encanta quedarnos en este hotel, es muy cómodo, limpio y el desayuno de domingo es delicioso. En las habitaciones que dan a la ciudad se escucha un poco el ruido de fiesta hasta la madrugada, pero nada que no permita dormir."
Ana 1-night trip
Posted 3 hours ago
InterContinental Real Guatemala by IHG

Frequently asked questions

What's it like in Santa Ana?
Travellers to the Santa Ana neighbourhood in Antigua Guatemala will be sure to enjoy their stay.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 15 hotels and other accommodation options in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view top deals in Santa Ana.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, make sure that you visit other sights such as Tanque La Unión or Museo del Hermano Pedro.