Santa Cruz Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Historical Center

Historical Center

7 out of top 10 points of interest in this area
4.5/5(631 area reviews)

Known for its fantastic nightlife, stunning cathedral and popular shops, there's plenty to explore in Historical Center. Top attractions like Casa de la Memoria Cultural Center and Calle Sierpes are major draws. Catch the metro at Plaza Nueva Tram Stop or Archivo de Indias Tram Stop to see more of the city.

Find hotels in Historical Center

Top hotels in Santa Cruz

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville

5 out of 5
San Fernando 2 Seville Seville
Fully refundableReserve now, pay when you stay
The price is 18.970.199 ₫ per night from 10 May to 11 May
18.970.199 ₫
20.867.219 ₫ total
10 May - 11 May
includes taxes & fees
9.4/10 Exceptional! (1,004 reviews)
Lovely room. Breakfast was amazing and the bar was great service. Food was the best at this hotel

Reviewed on 3 May 2026

Hotel Alfonso XIII, a Luxury Collection Hotel, Seville
Hotel Murillo

Hotel Murillo

2 out of 5
Calle Lope de Rueda, 7-9 Seville Seville
Fully refundableReserve now, pay when you stay
The price is 2.483.027 ₫ per night from 7 Jun to 8 Jun
2.483.027 ₫
2.731.329 ₫ total
7 Jun - 8 Jun
includes taxes & fees
8.8/10 Excellent! (1,024 reviews)
Good

Reviewed on 8 May 2026

Hotel Murillo
Hotel Amadeus Sevilla

Hotel Amadeus Sevilla

4 out of 5
Calle Farnesio 6 Seville Seville
Fully refundableReserve now, pay when you stay
The price is 4.740.930 ₫ per night from 1 Jun to 2 Jun
4.740.930 ₫
5.215.023 ₫ total
1 Jun - 2 Jun
includes taxes & fees
9.6/10 Exceptional! (1,199 reviews)
Nice hotel . Specially for music lover ,morning with classic piano performance so relaxing. Working distance to visit and lots restaurants and Tabas to enjoy

Reviewed on 6 May 2026

Hotel Amadeus Sevilla
See all 432 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz holiday package cost?
Get ready to book, because a trip to Santa Cruz starts from a tempting . When you combine your hotels, flights and car rentals into a package, you'll enjoy the biggest deals.
How do I get a cheap travel package to Santa Cruz?
Just think of all the fun things you could do in Santa Cruz with a pile of extra cash in your pocket. Watch your savings stack up when you combine your travel bookings into a Santa Cruz holiday package. You have plenty of choice when it comes to booking with Expedia too. In fact, you can select from over 550 airlines and 1null000null000 properties around the world. Whether you're enjoying a break with the whole family or travelling with someone special, exploring Santa Cruz is better with a package.
Where should I stay in Santa Cruz?
Most people who visit Santa Cruz put both Seville Cathedral and Alcázar on their must-see lists. Why not choose a hotel close to one of these iconic attractions?
What are the top hotels in Santa Cruz?
Puerta Catedral Holiday Suites and San Isidoro Hostel Sevilla are among the most well-known properties in Santa Cruz. Why not check out the rates and facilities at each and then make up your mind?
How far in advance should I book my Santa Cruz holiday?
Reserving your seat early with Expedia means one less thing to have to worry about. Most carriers advertise prices up to 12 months prior to take off. This is generally the cheapest time to book. If circumstances have left you booking late, great deals to Santa Cruz sometimes emerge in the weeks leading up to departure.
What does an Expedia Santa Cruz travel package include?
Hotels, car rentals and flights — we bring you the very best deals. All you'll have to do is decide on your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and tours. Our travel packages make it easy to craft an awesome Santa Cruz trip.
What should I know before booking a Santa Cruz travel package?
You'll pick up impressive savings when you bundle your flights, hotels and rental cars into a package. Plus, booking everything in one place just makes things easier. So why waste your time or money? Whether you're putting together an upscale romantic escape or a budget family adventure, explore our holiday packages today.
Can I choose my airline with a Santa Cruz Expedia holiday package?
Yes — that's the beauty of an Expedia package. You're in control. We have more than 550 airline partners around the world, so you have loads of choice when organising your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz holiday package?
Yes, it's possible to cancel your Santa Cruz booking if your travel plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.

Popular places to visit

Royal Alcázar of Seville

Royal Alcázar of Seville

5/5(593 reviews)

Royal Alcázar of Seville is just one of the places to see in Seville, so why not enjoy the other things to explore during your travels? Visit the stunning cathedral and shops in this culturally rich area.

Royal Alcázar of Seville
San Telmo Palace

San Telmo Palace

After visiting San Telmo Palace, make a plan to see the other sights and activities in Paseo de Las Delicias. Visit the stunning cathedral and shops in this family-friendly area.

San Telmo Palace
Triunfo Plaza

Triunfo Plaza

5/5(1 review)

You can learn about the history of Seville with a visit to Triunfo Plaza. Visit the shops and stunning cathedral in this romantic area.

Triunfo Plaza