The Best Hotels Closest to Santa Fe Depot Museum in Gainesville - 2026 Updated Prices

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Our top choices for Santa Fe Depot Museum hotels

A two-story house with a swimming pool, outdoor furniture, and a well-maintained garden.

A two-story house with a tiled roof, multiple windows, and a front porch.

A beach with a sunset, waves, and a few trees and structures in the distance.

A wooden deck with a hot tub, outdoor furniture, and a welcome sign on a building.

1. The Lancaster Manor B&B

0.8 km from Santa Fe Depot Museum

Jeffrey

5.377.764 ₫

6.184.429 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A modern hotel lobby with a wooden ceiling, a large TV, a sofa, a coffee table, and a patterned floor.

A modern hotel lobby with a wooden ceiling, a reception desk, a seating area with green sofas, and a visible kitchen in the background.

A hotel with a modern facade, a covered entrance, and a parking lot.

A swimming pool with clear lane markings, adjacent lounge chairs, and a tiled floor.

2. Fairfield Inn & Suites by Marriott Gainesville I-35

1.8 km from Santa Fe Depot Museum

BALTAZAR

2.482.889 ₫

2.855.323 ₫ total

includes taxes & fees

29 Oct - 30 Oct

A modern hotel room with a large bed, a desk, a chair, and a sofa.

A gym with treadmills, elliptical machines, and weight machines.

A Days Inn reception area with a stone counter, a dining area with tables and chairs, and a large window on the right side.

A reception area with a Days Inn sign, a counter with a tiled backsplash, a television, and a coffee machine.

3. Days Inn by Wyndham Gainesville

2.5 km from Santa Fe Depot Museum

Tina

1.607.458 ₫

1.848.577 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A buffet with labeled containers of omelets and other dishes.

A hotel room with a bed, a desk, a chair, a sofa, and a ceiling fan.

A Holiday Inn Express hotel with a covered entrance, multiple windows, and a brick facade.

A coffee station with two coffee machines and a variety of coffee pods and cups.

4. Holiday Inn Express & Suites Gainesville by IHG

1.1 km from Santa Fe Depot Museum

Donna

2.044.915 ₫

2.351.653 ₫ total

includes taxes & fees

17 Nov - 18 Nov

A spacious living area with a sofa, a glass-top coffee table, a desk with a computer, and a magazine rack. There is a dining area with tables and chairs in the background.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

A reception desk with a mosaic tile design, a framed welcome sign, and a small table with a blue sign.

A hotel hallway with carpeted floors, doors on both sides, and a ceiling with recessed lighting.

5. Super 8 by Wyndham Gainesville TX

2.7 km from Santa Fe Depot Museum

Sid

1.786.065 ₫

2.053.975 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A large indoor swimming pool with clear views through tall windows, a lounge chair, and a table with chairs.

A hotel room with a large bed, wooden headboard, bedside tables, a desk with a chair, and a television.

A room with a blue sofa, a small ottoman, a lamp, and a window with curtains.

A reception desk with a sign reading "Comfort Suites." There are two digital kiosks and a reception counter.

6. Comfort Suites Gainesville

2.5 km from Santa Fe Depot Museum

Tammera

1.840.424 ₫

2.116.487 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A kitchen with a countertop, a refrigerator, a ceiling fan, and a window.

A motel with a brick facade, a covered parking area, and a car parked in front.

A bedroom with a bed, a desk, a chair, an air conditioning unit, a door, and a window.

A small office with a desk, computer, chair, and a clock on the wall.

7. Budget Host Motel Gainesville

2.7 km from Santa Fe Depot Museum

Mark

1.423.675 ₫

1.637.226 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A spacious living area with a stone accent wall, a brown sofa, and a kitchen in the background.

A laundry area with two washing machines and a dryer, a water fountain, and a sign indicating guest laundry hours.

A long corridor with a dining area featuring tables and chairs, a kitchen area, and a reception desk.

A hotel room with two beds, a desk with a TV, a mirror, and a lamp.

8. Loyalty Inn Gainesville

3 km from Santa Fe Depot Museum

Jimmy

1.210.124 ₫

1.391.837 ₫ total

includes taxes & fees

22 Oct - 23 Oct

A hotel room with two beds, a desk with a chair, a television, and a minibar.

Two refrigerated beverage dispensers labeled 'CHILLED' and 'FROZEN' with various drinks inside.

A breakfast bar with coffee machines, a refrigerator, and a seating area with a wooden table and chairs.

9. Quality Inn Gainesville

0.9 km from Santa Fe Depot Museum

Roxann

1.423.675 ₫

1.656.641 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A hotel room with a bed, a desk with a computer, a TV, a microwave, and a refrigerator.

A spacious dining area with multiple wooden tables and chairs, a counter with food service equipment, and large windows with blinds.

A modern lobby with a green sofa, blue armchairs, a glass coffee table, and potted plants.

10. Suburban Studios Gainesville

0.9 km from Santa Fe Depot Museum

Lynzee

1.281.308 ₫

1.473.505 ₫ total

includes taxes & fees

26 Oct - 27 Oct

A spacious living room with patterned sofas, a coffee table, and a flat-screen TV mounted on the wall.

A Best Western hotel with a brick facade, a covered entrance, and stone pillars.

A hotel room with two beds, a desk, a TV, and a window.

A reception area with a curved reception desk, a flat-screen TV mounted on the wall, and framed artwork above the desk.

11. Best Western Red River Inn & Suites

13.9 km from Santa Fe Depot Museum

Douglas

2.484.701 ₫

2.782.865 ₫ total

includes taxes & fees

2 Nov - 3 Nov

A spacious kitchen with checkered flooring, wooden cabinets, and various appliances.

A kitchen with wooden cabinets, a refrigerator, and a tiled floor.

A gym with treadmills, elliptical machines, and a weight bench.

A laundry area with a wall-mounted soap, bleach, and softener dispenser, a washing machine, and stacked dryers.

12. Hampton Inn & Suites Gainesville

6.4 km from Santa Fe Depot Museum

Charlie

1.889.087 ₫

2.180.992 ₫ total

includes taxes & fees

9 Nov - 10 Nov

A hotel room with two beds, each with a green headboard, white bedding, and red accents. There are abstract paintings on the wall above the beds.

A compact kitchen area with a microwave and a black dishwasher.

A small, modern room with a gray sofa, a green armchair, a bed with a red blanket, a white pillow, and a painting on the wall.

A bathroom with a toilet, a shower curtain, a towel rack with towels, and a toilet paper holder.

13. Lindsay Inn

7.9 km from Santa Fe Depot Museum

Tammera

1.811.950 ₫

2.029.384 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A spacious lobby with a reception desk, a staircase, and seating area.

A hotel room with a large bed, two bedside lamps, a bathroom with a bathtub, and a large mirror.

A hotel with a red roof, a covered entrance, and a sign for La Quinta Inn & Suites.

A spacious lobby with a fireplace, patterned wallpaper, and modern seating arrangements.

14. La Quinta Inn & Suites by Wyndham Gainesville

5.7 km from Santa Fe Depot Museum

Lupe

2.222.227 ₫

2.606.813 ₫ total

includes taxes & fees

19 Nov - 20 Nov

A modern living room with a fireplace, two bean bag chairs, a television, and large windows with blinds.

A hotel room with a bed, a chair, a small table, and a bathroom with a sink and mirror.

A modern restaurant with a bar area, dark wooden flooring, and contemporary furniture.

A modern hotel lobby with dark wood flooring, comfortable seating, a flat-screen TV, and a reception desk.

15. Red River Inn And Suites

13.9 km from Santa Fe Depot Museum

Troy

2.562.615 ₫

2.870.128 ₫ total

includes taxes & fees

20 Oct - 21 Oct

A hotel room with a bed, bedside table, lamp, and a television on a dresser.

A kitchen with wooden cabinets, a black countertop, and a black rug.

A hotel room with a bed, bedside lamps, a telephone, a nightstand, a window with curtains, and a door.

A spacious lobby with a ceiling fan, a reception desk, a refrigerator, and a door leading to the outside.

16. OYO Hotel Valley View TX, I-35

16.5 km from Santa Fe Depot Museum

Brian

1.580.280 ₫

1.864.729 ₫ total

includes taxes & fees

3 Nov - 4 Nov

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Compare popular hotels close to Santa Fe Depot Museum

Property	Property class	Guest rating
The Lancaster Manor B&B	10.0 Exceptional 115 reviews	View
Fairfield Inn & Suites by Marriott Gainesville I-35	8.6 Excellent 1,002 reviews	View
Days Inn by Wyndham Gainesville	7.8 Good 1,002 reviews	View
Holiday Inn Express & Suites Gainesville by IHG	7.8 Good 1,001 reviews	View
Super 8 by Wyndham Gainesville TX	7.4 Good 1,002 reviews	View

Top Santa Fe Depot Museum Hotel Reviews

Super 8 by Wyndham Gainesville TX

10/10 Excellent

"Love this place! Will return if work brings me back to Gainesville TX"

Loyalty Inn Gainesville

8/10 Good

"Clean room and tiny bathroom"

Comfort Suites Gainesville

8/10 Good

"We stayed at this property because of its location and proximity to the casinos that we were going to. Everything was good and I would recommend staying at this location."

OYO Hotel Valley View TX, I-35

10/10 Excellent

"It was a easy check in and the room was clean and the bathroom was also clean. Overall I would come back and stay again."

Victorian Inns By OYO Whitesboro U.S. Hwy 82

8/10 Good

"It was really positive experiences"

Best Western Red River Inn & Suites

10/10 Excellent

"The staff was helpful, friendly, and courteous. The lobby and common areas were clean and festively decorated. The room was clean and in good order. The breakfast was delicious."

Lindsay Inn

10/10 Excellent

"No breakfast, but room is clean and nice!! Modern bedding and furniture. Truly recommend staying here!! AA+"

Oak Meadow Ranch

10/10 Excellent

"Amazing adventure! Book the Tranquility Cabin and the Serenity Slot experience! We’re still on a high from this experience! It was an absolutely amazing adventure that exceeded every single one of our expectations. The entire process was seamless and incredibly well-organized. The guides/hosts were phenomenally knowledgeable, patient, and full of infectious energy that made the day even more special. It balanced pure excitement with wonderful hospitality, leaving both of us completely captivated. It was genuinely a life-disrupting, beautiful memory that we will treasure forever. Don't even hesitate—just book it! For us, we’re looking forward to arranging to bring more family with us next time for a possible giraffe adventure! Thank you again Oak Meadow Ranch for such a one-a-lifetime adventure!"

The Lancaster Manor B&B

10/10 Excellent

"You will not find a better couple to host you and you will not find a place with more character than this mansion. Everything was perfect from the check in to the food. We will be back!"

Other attractions near Santa Fe Depot Museum

Cooke County Courthouse

7.6/10 (89 reviews)

After visiting Cooke County Courthouse, make a plan to see the other sights and activities in Gainesville. While you're in the area, find time to visit its casinos.

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Depot Park

Depot Park is just one of the places to see in Gainesville, so why not enjoy the other things to explore during your travels? While in this family-friendly area, find time to visit its casinos.

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Butterfield Stage Players

7.2/10 (64 reviews)

You can enjoy a show at Butterfield Stage Players during your stay in Gainesville. While you're in the area, find time to visit its casinos.

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State Theater

7.4/10 (54 reviews)

You can enjoy a show at State Theater during your stay in Gainesville. While you're in the area, find time to visit its casinos.

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Morton Museum

7.2/10 (68 reviews)

You can spend time studying the exhibits at Morton Museum during your trip to Gainesville. While you're in the area, find time to visit its casinos.

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Tom Thumb Park

After visiting Tom Thumb Park, make a plan to see the other sights and activities in Gainesville. While in this family-friendly area, find time to visit its casinos.

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Jaycee Park

After visiting Jaycee Park, make a plan to see the other sights and activities in Gainesville. While in this family-friendly area, find time to visit its casinos.

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Gainesville War Memorial

8.0/10 (109 reviews)

Find out about the history of Gainesville with a stop at Gainesville War Memorial. While you're in the area, find time to visit its casinos.

See properties

Frequently asked questions

What's the area like around Santa Fe Depot Museum?

Santa Fe Depot Museum is located in a welcoming area of Gainesville known for its first-class casinos. If you're looking for a convenient place to stay, take a look at the 17 hotels and other accommodation options you'll find within a mile.

How many hotels are there near Santa Fe Depot Museum?

Expedia has 17 hotels and other accommodation options within a mile from Santa Fe Depot Museum.

If I need to cancel the hotel reservation for my stay near Santa Fe Depot Museum, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Santa Fe Depot Museum.

What can I see and do near Santa Fe Depot Museum?

You can enjoy live performances at Butterfield Stage Players and State Theater. Get outside and spend some time strolling around Leonard Park, Tom Thumb Park and Jaycee Park. Gainesville War Memorial and Frank Buck Zoo are both worth a visit while you're out exploring.

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Treat yourself

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Our top choices for Santa Fe Depot Museum hotels

1. The Lancaster Manor B&B

2. Fairfield Inn & Suites by Marriott Gainesville I-35

3. Days Inn by Wyndham Gainesville

4. Holiday Inn Express & Suites Gainesville by IHG

5. Super 8 by Wyndham Gainesville TX

6. Comfort Suites Gainesville

7. Budget Host Motel Gainesville

8. Loyalty Inn Gainesville

9. Quality Inn Gainesville

10. Suburban Studios Gainesville

11. Best Western Red River Inn & Suites

12. Hampton Inn & Suites Gainesville

13. Lindsay Inn

14. La Quinta Inn & Suites by Wyndham Gainesville

15. Red River Inn And Suites

16. OYO Hotel Valley View TX, I-35

Compare popular hotels close to Santa Fe Depot Museum

Top Santa Fe Depot Museum Hotel Reviews

Super 8 by Wyndham Gainesville TX

Loyalty Inn Gainesville

Comfort Suites Gainesville

OYO Hotel Valley View TX, I-35

Victorian Inns By OYO Whitesboro U.S. Hwy 82

Best Western Red River Inn & Suites

Lindsay Inn

Oak Meadow Ranch

The Lancaster Manor B&B

Other attractions near Santa Fe Depot Museum

Cooke County Courthouse

Depot Park

Butterfield Stage Players

State Theater

Morton Museum

Tom Thumb Park

Jaycee Park

Gainesville War Memorial

Frequently asked questions

Explore a world of travel with Expedia