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9 Dec - 10 Dec
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10 Dec - 11 Dec
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12 Dec - 14 Dec
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19 Dec - 21 Dec

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Our top choices for Santa Fe hotels

Breakfast area
Ayenda Casa San Pablo

Ayenda Casa San Pablo

2.5 star property
Santa Fe
8.0 out of 10, Very good, (7)
"Room was very small, the bathroom tiny and uncomfortable to navigate. Facilities were clean and the staff courteous."
United States
Jose
The price is 1.512.460 ₫
1.512.460 ₫ total
10 Dec - 11 Dec
Ayenda Casa San Pablo
Front of property
Hotel Boutique Olaya 54

Hotel Boutique Olaya 54

3.0 star property
Santa Fe
10.0 out of 10, Exceptional, (1)
"Convenient and cozy . Per friendly was a plus ! "
United States
Alfonso
The price is 1.619.847 ₫
1.619.847 ₫ total
13 Dec - 14 Dec
Hotel Boutique Olaya 54
4 restaurants, breakfast served
Dann Carlton Medellin Hotel

Dann Carlton Medellin Hotel

4.5 star property
Provenza, 2 km from Santa Fe
8.8 out of 10, Excellent, (1654)
"Excelente hotel 5 estrellas. "
United States
Emmanuel
The price is 3.118.395 ₫
3.118.395 ₫ total
14 Dec - 15 Dec
Dann Carlton Medellin Hotel
View from room
Calle Flora Hotel by Jalo

Calle Flora Hotel by Jalo

3.5 star property
Zona Rosa, 2.2 km from Santa Fe
9.2 out of 10, Wonderful, (288)
"Good place to stay"
United States
Obed
The price is 2.059.793 ₫
2.059.793 ₫ total
25 Dec - 26 Dec
Calle Flora Hotel by Jalo
Couples treatment room(s), sauna, hot tub, Turkish bath/hammam
Movich Hotel Las Lomas

Movich Hotel Las Lomas

4.0 star property
17.1 km from Santa Fe
9.0 out of 10, Wonderful, (1006)
"Its a food hotel , perfectly "
United States
Roberto
The price is 4.264.735 ₫
4.264.735 ₫ total
19 Dec - 20 Dec
Movich Hotel Las Lomas
Outdoor pool, open 9:00 AM to 8:00 PM, pool umbrellas, pool loungers
Heiss Hotel By Jalo

Heiss Hotel By Jalo

4.0 star property
El Poblado, 1.3 km from Santa Fe
9.2 out of 10, Wonderful, (1021)
"Great Place to stay"
United States
Douglas
The price is 2.000.695 ₫
2.000.695 ₫ total
7 Jan - 8 Jan 2026
Heiss Hotel By Jalo
Restaurant
Hunters By Jalo

Hunters By Jalo

3.0 star property
Provenza, 2.3 km from Santa Fe
9.2 out of 10, Wonderful, (189)
"Really nice hotel! "
United States
IBRAHIM
The price is 1.991.493 ₫
1.991.493 ₫ total
17 Dec - 18 Dec
Hunters By Jalo
Superior Double Room, 1 Queen Bed | Minibar, in-room safe, desk, blackout curtains
Hotel Lagoon

Hotel Lagoon

3.5 star property
19 km from Santa Fe
9.2 out of 10, Wonderful, (297)
"Nice property, very good food, very relaxing."
United States
Kevin
The price is 3.210.389 ₫
3.210.389 ₫ total
11 Dec - 12 Dec
Hotel Lagoon
Terrace/patio
Landmark Hotel

Landmark Hotel

4.0 star property
Manila, 1.4 km from Santa Fe
9.6 out of 10, Exceptional, (221)
"The room was pretty clean and the staff very friendly and helpful "
United States
Pedro Julio Pons
The price is 3.254.819 ₫
3.254.819 ₫ total
17 Dec - 18 Dec
Landmark Hotel
Outdoor pool, free pool cabanas
Marquee Hotel

Marquee Hotel

3.0 star property
Zona Rosa, 2.1 km from Santa Fe
9.2 out of 10, Wonderful, (117)
"Clean room, amenities and scenery was amazing "
United States
Shana
The price is 3.787.848 ₫
3.787.848 ₫ total
10 Dec - 11 Dec
Marquee Hotel
Al fresco dining
Selvario 36 Hotel

Selvario 36 Hotel

4.0 star property
Provenza, 2.3 km from Santa Fe
9.4 out of 10, Exceptional, (581)
"Great experience "
United States
Marcelis
Selvario 36 Hotel
Free daily buffet breakfast
Hotel Du Parc

Hotel Du Parc

4.5 star property
Zona Rosa, 2 km from Santa Fe
9.4 out of 10, Exceptional, (1002)
"Good amenities, friendly staff and the breakfast buffet is very good."
United States
Satish
The price is 3.625.026 ₫
3.625.026 ₫ total
16 Dec - 17 Dec
Hotel Du Parc
Outdoor pool
The Charlee Hotel

The Charlee Hotel

5.0 star property
Zona Rosa, 2.2 km from Santa Fe
8.8 out of 10, Excellent, (1005)
"Amazing stay! "
United States
Jasmin
The price is 4.845.824 ₫
4.845.824 ₫ total
16 Dec - 17 Dec
The Charlee Hotel
Arcade
Diez Hotel Categoria Colombia

Diez Hotel Categoria Colombia

4.0 star property
Provenza, 2.3 km from Santa Fe
9.4 out of 10, Exceptional, (1005)
"Very Clean, friendly staff, and great value for price."
United States
Jason
The price is 2.654.993 ₫
2.654.993 ₫ total
7 Jan - 8 Jan 2026
Diez Hotel Categoria Colombia
Jetted bathtub
La Martina Boutique Hotel

La Martina Boutique Hotel

3.5 star property
Manila, 1.4 km from Santa Fe
8.4 out of 10, Very good, (279)
"Very nice hotel, will be staying here again when I come back to Medellín "
United States
Ryan
La Martina Boutique Hotel
Front of property
Hotel El Zarzo

Hotel El Zarzo

4.0 star property
Zona Rosa, 2.1 km from Santa Fe
9.6 out of 10, Exceptional, (249)
"Great hotel and location. Amazing staff and very clean. "
United States
Jeremy
The price is 4.393.483 ₫
4.393.483 ₫ total
5 Jan - 6 Jan 2026
Hotel El Zarzo
Junior Room | Premium bedding, down duvets, minibar, in-room safe
The O By Seekers Medellín

The O By Seekers Medellín

3.5 star property
Provenza, 2.3 km from Santa Fe
9.0 out of 10, Wonderful, (168)
"Love staying here! Staff is amazing food is amazing rooms are immaculate "
United States
Alberto N
The O By Seekers Medellín
Exterior
Hotel Celestino Boutique

Hotel Celestino Boutique

3.0 star property
Zona Rosa, 2.3 km from Santa Fe
9.4 out of 10, Exceptional, (190)
"The room was amazing with a beautiful balcony, and the staff was very welcoming and attentive. "
United States
Arlene
The price is 2.357.798 ₫
2.357.798 ₫ total
24 Dec - 25 Dec
Hotel Celestino Boutique
Reception
The Host Medellin Only Adults

The Host Medellin Only Adults

3.0 star property
Astorga, 1.8 km from Santa Fe
10.0 out of 10, Exceptional, (9)
"Superb location with a quiet street close to the action. Walkable, safe, and the hotel itself was nice. We especially loved the included breakfast - delicious, healthy, and warm service. "
Canada
Karen
The price is 5.645.050 ₫
5.645.050 ₫ total
10 Dec - 11 Dec
The Host Medellin Only Adults
Restaurant
Hashtag 98 Hotel By Jalo

Hashtag 98 Hotel By Jalo

4.0 star property
Zona Rosa, 1.9 km from Santa Fe
9.2 out of 10, Wonderful, (1604)
"Excellent costumer service clean rooms great location "
United States
sandra
The price is 2.135.444 ₫
2.135.444 ₫ total
18 Dec - 19 Dec
Hashtag 98 Hotel By Jalo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santa Fe

Find the best Santa Fe areas for the activities you enjoy most.
El Castillo Museum showing heritage architecture and château or palace

El Poblado

El Poblado is highly notable for its popular shops, and you might want to visit top sights like Golden Mile and Oviedo Shopping Center. See more of Medellín by jumping on the metro at Poblado Station or Aguacatala Station.

Rock of Guatape featuring a house, mist or fog and tranquil scenes

Laureles

Laureles is known for its ample dining options, and you can make a stop by Unicentro Shopping Center and Belén Andrés Escobar Sports Complex while in the area.

Provenza

If you're looking for some top things to see and do in Provenza and surrounding area, you can visit Golden Mile and Oviedo Shopping Center.

Laureles - Estadio

While you're in Laureles - Estadio, take in top sights like Atanasio Giradot Stadium or Unicentro Shopping Center, and hop on the metro to see more of the city at Estadio Station or Suramericana Station.

Zona Rosa

When in Zona Rosa, you can plan a visit to Golden Mile and Oviedo Shopping Center, some noteworthy sights in the nearby area.

Top Santa Fe Hotel Reviews

Landmark Hotel

Landmark Hotel

10/10 Excellent
"I had an amazing stay at Landmark Hotel Medellín! The property is modern, beautifully designed, and perfectly located. The rooms are spacious, stylish, and very clean — every detail feels well thought out. The rooftop area is definitely a highlight: great city views, a relaxing atmosphere, and a perfect spot to unwind or take pictures. The service was outstanding. The staff was friendly, attentive, and always ready to help with recommendations or anything I needed. Check-in and check-out were smooth, and I always felt welcome and taken care of. The location is fantastic — close to trendy areas, great restaurants, and safe places to walk around. Whether you’re in Medellín for business or leisure, this hotel is a perfect choice. Overall, a wonderful experience. I would absolutely stay here again and recommend it to anyone visiting the city! "
Estefania 10-night trip
Posted 2 days ago
Landmark Hotel

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Frequently asked questions

What's it like in Santa Fe?
You'll be sure to have fun exploring Medellín's Santa Fe neighbourhood. Consider a visit to Santa Fe Zoological Park as part of your Santa Fe travel plans.
How many hotels will I be able to find in Santa Fe?
If you're searching for places to stay in Medellín, choose from one of Expedia's 13 hotels and other accommodation options in Santa Fe.
If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?
Yes, you'll find most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then use the "fully refundable" filter to review the top deals on offer in Santa Fe.
What is there to do around this Medellín neighbourhood?
Santa Fe Zoological Park is an attraction you might want to check out while you're in Santa Fe. While you're out sightseeing, Medellin's Museum of Modern Art and Monterrey Comercial Mall are a couple of additional sights to visit in Medellín.