A coastal archaeological site with ruins and boats on the water.

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Check availability on Santiago Spa Hotels

Tonight
8 Aug - 9 Aug
Tomorrow
9 Aug - 10 Aug
Next weekend
14 Aug - 16 Aug
In two weeks
21 Aug - 23 Aug

Our top choices for Santiago hotels with a spa

3 outdoor pools, free pool cabanas, pool umbrellas
3 outdoor pools, free pool cabanas, pool umbrellas
Free daily cooked-to-order breakfast
Front of property

1. Hotel Mykonos Panama

Hotel Mykonos Panama
Nuevo Santiago
2.948.063 ₫
3.242.869 ₫ total
includes taxes & fees
10 Aug - 11 Aug
Hotel Mykonos Panama
View all properties

Choose what matters most at spa hotels in Santiago

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top Santiago Hotel Reviews

Hotel Gran David

Hotel Gran David

10/10 Excellent
"Excelente"
Itzy 1-night trip
Posted 1 day ago
Hotel Gran David
Hotel Mykonos Panama

Hotel Mykonos Panama

10/10 Excellent
"Very well located"
Ismael 1-night trip
Posted 6 days ago
Hotel Mykonos Panama

Frequently asked questions

Looking for a spa hotel in Santiago?
Book one of our fantastic spa hotels and treat yourself from the moment you arrive. Enjoy the cathedral and bars in Santiago—your day trip starts here. Enjoy the shops and many popular restaurants during your holiday. Hotels with spas are the perfect way to break out of your daily routine and add a layer of luxury to your holiday.
What's there to see and do in Santiago?
Take in the sights and attractions that Santiago offers with a visit to Catedral of Santiago Apostol, Omar Torrijos Herrera Stadium and Plaza Banconal. If you have a bit of extra time while you're in the area, you might want to check out Parque Acuatico Italia Guadalupe Panama and Los Pozos Termales.
What is a Santiago spa hotel?
Spa hotels in Santiago provide lodging and have a full on-site spa offering services including massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation and relaxation.