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Our top choices for South Carolina Midlands hotels

1. Howard Johnson by Wyndham Florence

Florence

Miriam

1.962.890 ₫ total

includes taxes & fees

25 Jul - 26 Jul

2. Holiday Inn Express North Augusta by IHG

North Augusta

Grady

3.163.317 ₫ total

includes taxes & fees

6 Aug - 7 Aug

3. Hampton Inn & Suites Columbia Killian Road

Columbia

Lorita

3.390.846 ₫ total

includes taxes & fees

18 Aug - 19 Aug

4. Fairfield Inn & Suites by Marriott Santee

Santee

Erik

3.917.014 ₫ total

includes taxes & fees

11 Aug - 12 Aug

5. Hilton Garden Inn Columbia/Harbison

Columbia

Albert

2.819.652 ₫ total

includes taxes & fees

30 Jul - 31 Jul

6. Park Inn by Radisson Florence, SC

Florence

Kimberly

2.354.876 ₫ total

includes taxes & fees

16 Aug - 17 Aug

Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi

7. Baymont by Wyndham Santee

Santee

Kate

2.336.509 ₫ total

includes taxes & fees

26 Jul - 27 Jul

8. Aiken Midtown Hotel

Aiken

Evelio

2.505.188 ₫ total

includes taxes & fees

28 Jul - 29 Jul

9. Carriage House Inn

Aiken

Cindy

3.225.693 ₫ total

includes taxes & fees

27 Jul - 28 Jul

10. Country Inn & Suites by Radisson, Aiken South

Aiken

John

2.606.405 ₫ total

includes taxes & fees

16 Aug - 17 Aug

11. Hampton Inn Santee-I-95

Santee

Michael

3.708.455 ₫ total

includes taxes & fees

16 Aug - 17 Aug

12. Holiday Inn Express & Suites Columbia-I-20 @ Clemson Rd by IHG

Columbia

matthew

3.163.317 ₫ total

includes taxes & fees

9 Aug - 10 Aug

13. Comfort Inn & Suites Florence Center Area

Florence

Monica

3.261.481 ₫ total

includes taxes & fees

2 Aug - 3 Aug

14. La Quinta Inn by Wyndham Columbia NE/Fort Jackson

Columbia

Franco

2.730.655 ₫ total

includes taxes & fees

8 Aug - 9 Aug

15. Springhill Suites by Marriott Columbia near Fort Jackson

Columbia

Mark

3.212.535 ₫ total

includes taxes & fees

23 Aug - 24 Aug

16. Red Roof Inn Orangeburg

Orangeburg

"The only reason I didn't give the location an EXCELLENT rating is because the day of checkout, the staff knocked on my door twice prior to check out. That's one of those things that truly irritates me. We aren't that proactive on checking in! However it was a great stay. Love the location and there's plenty of food and stores in walking distance. The area was quiet. The place felt and was safe. Definitely will stay on my next visit."

William

1.840.207 ₫ total

includes taxes & fees

31 Jul - 1 Aug

17. Best Western Plus Santee Inn

Santee

Lorraine

3.475.948 ₫ total

includes taxes & fees

9 Aug - 10 Aug

18. Hyatt Place Sumter / Downtown

Sumter

Lisa

4.008.299 ₫ total

includes taxes & fees

24 Aug - 25 Aug

19. Tru by Hilton Rock Hill

Rock Hill

Thomas

2.513.783 ₫ total

includes taxes & fees

11 Aug - 12 Aug

20. Best Western Rock Hill

Rock Hill

Robert

2.261.997 ₫ total

includes taxes & fees

27 Jul - 28 Jul

View all properties

Holiday Rentals in South Carolina Midlands

Apartment

Easy Access to I-77 & I-20: Columbia Duplex!

Columbia

"Good rental. The only downside was that there was a strong cigar odor the first two days. I also found a few uncleaned hairs lying around on the counter and bed. Other than that, it’s a good home for a quick trip. Especially if you’re visiting for Fort Jackson purposes."

Aparthotel

StudioRes by Marriott Columbia Harbison

Columbia

"Probably one of the best hotels I’ve been to in a while, especially considering the price!"

Aparthotel

stayAPT Suites Columbia-Irmo Harbison

Irmo

"The property was clean the kitchen was nice."

Holiday Home

Signature Townhome, 3 Bedrooms, Balcony, River View | Water view

Beautiful 3BR Townhouse

East Augusta

"The water view and close proximity to restaurants and shops The place was as pictured and some. Very quiet and relaxing place. Will definitely be booking again"

Holiday Home

Wyndham Vacation Resorts Lake Marion

Santee

"Beautiful resort with quiet and peaceful surroundings "

Cottage

3 Mi to Marina: Quiet Getaway w/ Deck in Lexington

Lexington

"Very cozy home lots of room and kept clean!"

Aparthotel

stayAPT Suites Rock Hill

Rock Hill

"When I first got there they walked me to my room and it smelled like urine. She said she would get the cleaner to clean it again and when I came back it still smelled like urine. The entrance area to the rooms the door did not lock like they said it would; unsecured. The beds were extremely hard. The front desk people said they would move me to a better room then they wouldn’t."

Cottage

Bright Hopkins Home w/ Game Room & Fire Pit!

Hopkins

Apartment

Backyard Oasis w/ Pool: Sunny Sumter Studio!

Sumter

"The studio was very clean, decorated nicely, and cozy. The location is quiet and easy to find. Communication was punctual. I really enjoyed my stay"

Cottage

Family Home w/ Fire Pit, 2 Mi to Lake Access

Lexington

"Thank you so much for having spices in the drawer"

Cottage

Peaceful Camden Vacation Rental ~ 3 Mi to Town!

Camden

"Location was perfect for us. Very cozy, and clean. Hadn't been modernized, but it was in great shape. Nasolgic; felt like I was visiting my grandparents! Only having one bathroom was a bit challenging, but we made it work!"

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Cottage

Private Boat Dock: Waterfront Lake Murray Haven

Newberry Shores

"Beautiful home! Would stay here again."

Cottage

Pet-friendly Ehrhardt Home w/ Private Pond & Yard!

Ehrhardt

"The property is beautiful. The supplies for smores was a great surprise. Great pet friendly stay. "

See all holiday rentals

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Stay near popular South Carolina Midlands attractions

A cityscape at dusk with illuminated buildings, a prominent dome structure, and a well-lit street.

University of South Carolina

9.0/10 (2,467 reviews)

Explore the campus of University of South Carolina, a top university in Columbia. Experience the area's acclaimed theatre scene or attend a sporting event.

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Learn more about South Carolina Midlands

Gourmet restaurants, a university vibe and top sights from Fort Jackson to Carowinds Theme Park—discover South Carolina Midlands, a destination also famous for its shopping.

See all hotels in South Carolina Midlands

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Top South Carolina Midlands Hotel Reviews

Courtyard by Marriott Columbia Downtown at USC

10/10 Excellent

"N/A"

Park Inn by Radisson Florence, SC

10/10 Excellent

"My husband has stayed at this property, but this was my first time. Everything about it was great - the room was clean and spacious, the staff was friendly and helpful, and it's less than 15 minutes from Buc-ee's, which was a huge selling point :) We had two dogs with us and the pet area is a bit small, but it worked fine for our needs. The bathroom in our room was really nice and a good size, so that was an unexpected bonus. Highly recommend!"

Cambria Hotel Columbia Downtown The Vista

10/10 Excellent

"The greatest second option ever. My family had our 80th* Family Reunion and I wasn’t sure if I was going to make it due to job commitments. Fortunately I was able to make it; however, the hotel I was supposed to stay at was booked. Frustrated I began looking around the area and I came across the Cambria. I looked at Cambria based off the pictures from the website, only to look better in person. From the time we walked in the front staff was great. The young lady at the front named Kayla was wonderful. There was another young lady helping someone else and she was just as pleasant, based off what I could hear. I went to my room to put my things away and the room was just what I needed. Stocked coffee bar, oversized shower, a real couch, true blackout curtains, and I could set the temperature as cool as I wanted in that hot SC weather. I went back to the host hotel that the family was staying at bragging about all the amenities I had. They had a snack bar and pop machines, while I had a fully stocked bar and restaurant. Long story short, several of my family members ended up having drinks with me at the bar. I would chose the Cambria 10 times out 10. My only negative was the unexpected valet charge which really wasn’t that bad. I would chose the Cambria in any city, anytime. Everything was Alright, and by alright I mean ALL Right. I will be back."