Search Hotels in South Mission Beach, San Diego

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19 Dec - 20 Dec
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20 Dec - 21 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for South Mission Beach hotels

Exterior
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego
4.0 star property
Marina District, 10 km from South Mission Beach
9.0 out of 10, Wonderful, (2875)
"Lovely hotel with friendly staff."
United States
Lynnea
The price is 3.973.565 ₫
6.041.055 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Manchester Grand Hyatt San Diego
Lobby lounge
The Bristol Hotel San Diego

The Bristol Hotel San Diego

The Bristol Hotel San Diego
3.5 star property
10 km from South Mission Beach
8.6 out of 10, Excellent, (1458)
"So clean, Very Nice staff, convenient location ! "
United States
Cindy
The Bristol Hotel San Diego
Meeting facility
The Westin San Diego Bayview

The Westin San Diego Bayview

The Westin San Diego Bayview
4.0 star property
9.7 km from South Mission Beach
8.6 out of 10, Excellent, (1070)
"I loved the hotel rooms bar area jacuzzi area everything was great it was in a pretty location will definitely come back "
United States
Alliyah
The price is 3.348.413 ₫
4.645.450 ₫ total
includes taxes & fees
29 Dec - 30 Dec
The Westin San Diego Bayview
3 restaurants, breakfast, lunch, dinner served; Regional cuisine
Wyndham San Diego Bayside

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
9.1 km from South Mission Beach
8.4 out of 10, Very good, (6041)
"Always an amazing stay"
United States
Jana
The price is 3.556.472 ₫
4.886.687 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Wyndham San Diego Bayside
5 outdoor pools, a heated pool, pool umbrellas, pool loungers
Paradise Point Resort & Spa

Paradise Point Resort & Spa

Paradise Point Resort & Spa
4.0 star property
Mission Bay, 1.8 km from South Mission Beach
8.6 out of 10, Excellent, (2352)
"Great stay, top tier service and excellent customer care "
Canada
Meriem
The price is 3.403.845 ₫
5.305.104 ₫ total
includes taxes & fees
11 Jan - 12 Jan 2026
Paradise Point Resort & Spa
2 outdoor pools, open 6 AM to 10:00 PM, pool cabanas (surcharge)
Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
Marina District, 10.3 km from South Mission Beach
9.2 out of 10, Wonderful, (1950)
"Amazing hotel Superb view Friendly staff Clean and neat rooms "
United States
Chirag
The price is 4.451.182 ₫
6.544.306 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Marriott Marquis San Diego Marina
View from property
The Wayfarer San Diego

The Wayfarer San Diego

The Wayfarer San Diego
4.0 star property
Mission Beach, 2.8 km from South Mission Beach
9.4 out of 10, Exceptional, (1713)
"Great location great staff great stay. Would stay again "
United States
Regina
The price is 4.716.964 ₫
5.421.943 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Wayfarer San Diego
Room, 2 Queen Beds (Trendy, Firepit) | Lobby
Town and Country San Diego

Town and Country San Diego

Town and Country San Diego
4.0 star property
7.9 km from South Mission Beach
8.6 out of 10, Excellent, (1324)
"Great Resort, the staff were nice"
United States
Aryana
The price is 3.780.150 ₫
5.253.224 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Town and Country San Diego
Lobby
Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
4.0 star property
7.8 km from South Mission Beach
9.2 out of 10, Wonderful, (2943)
"Everything was super comfortable and the room was surprisingly affordable for the amenities you get. We will definitely stay there again if we go to San Diego."
United States
Eric
The price is 4.003.827 ₫
4.602.198 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Legacy Resort Hotel & Spa
Premium bedding, pillow-top beds, desk, laptop workspace
Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego

Staypineapple, Hotel Z, Gaslamp San Diego
3.0 star property
Gaslamp Quarter, 10.7 km from South Mission Beach
9.4 out of 10, Exceptional, (1001)
"Great location "
United States
Mohammad
The price is 2.344.666 ₫
3.479.028 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Staypineapple, Hotel Z, Gaslamp San Diego
Lobby
Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
Marina District, 9.8 km from South Mission Beach
9.0 out of 10, Wonderful, (1550)
"Clean room, friendly staff, great property. "
United States
MIGUEL
The price is 4.509.865 ₫
6.183.671 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
Embassy Suites by Hilton San Diego Bay Downtown
Exterior
Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina

Best Western Plus Island Palms Hotel & Marina
3.0 star property
6.2 km from South Mission Beach
8.8 out of 10, Excellent, (1555)
"Staff was great, easy check in and great location"
United States
Alysa
The price is 2.926.228 ₫
3.363.553 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Best Western Plus Island Palms Hotel & Marina
2 outdoor pools, a heated pool, pool loungers
The Dana on Mission Bay

The Dana on Mission Bay

The Dana on Mission Bay
3.5 star property
Mission Bay, 1.5 km from South Mission Beach
9.0 out of 10, Wonderful, (3929)
"Always love staying here. Staff was very courteous and the rooms very clean. "
United States
Eric
The price is 3.657.785 ₫
4.730.741 ₫ total
includes taxes & fees
21 Dec - 22 Dec
The Dana on Mission Bay
Beach nearby
Inn By The Sea La Jolla

Inn By The Sea La Jolla

Inn By The Sea La Jolla
3.5 star property
9.2 km from South Mission Beach
9.4 out of 10, Exceptional, (1742)
"Delightful stay. Perfect location. "
United States
Nicole
The price is 3.955.144 ₫
4.546.240 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Inn By The Sea La Jolla
Outdoor pool, open 7:00 AM to 10:00 PM, pool cabanas (surcharge)
San Diego Mission Bay Resort

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 4.4 km from South Mission Beach
8.4 out of 10, Very good, (1310)
"Room was super clean and updated, location up against the bay was perfect. We really enjoyed our stay and want to come back soon!"
United States
Haley
The price is 3.875.147 ₫
5.640.883 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
San Diego Mission Bay Resort
View from room
Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy

Courtyard by Marriott San Diego Downtown Little Italy
4.0 star property
Little Italy, 9.5 km from South Mission Beach
9.0 out of 10, Wonderful, (118)
"It was a nice place to stay at"
United States
Eric
The price is 3.110.181 ₫
3.606.099 ₫ total
includes taxes & fees
23 Dec - 24 Dec
Courtyard by Marriott San Diego Downtown Little Italy
Exterior
Bay Club Hotel & Marina

Bay Club Hotel & Marina

Bay Club Hotel & Marina
3.5 star property
6.1 km from South Mission Beach
9.2 out of 10, Wonderful, (3200)
"Great stay and location!"
United States
Jason
The price is 3.055.171 ₫
3.511.766 ₫ total
includes taxes & fees
5 Jan - 6 Jan 2026
Bay Club Hotel & Marina
Property grounds
Humphreys Half Moon Inn

Humphreys Half Moon Inn

Humphreys Half Moon Inn
3.5 star property
5.9 km from South Mission Beach
9.2 out of 10, Wonderful, (2699)
"Great stay"
United States
Michael
The price is 3.920.935 ₫
5.033.219 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Humphreys Half Moon Inn
Breakfast, lunch and dinner served
Grande Colonial Hotel

Grande Colonial Hotel

Grande Colonial Hotel
4.0 star property
9.4 km from South Mission Beach
9.4 out of 10, Exceptional, (1000)
"Great location,excellent restaurant downstairs. Nice rooms. Excellent architecture."
United States
daniel
The price is 5.569.570 ₫
7.763.188 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Grande Colonial Hotel
Property amenity
Catamaran Resort and Spa

Catamaran Resort and Spa

Catamaran Resort and Spa
4.0 star property
Mission Beach, 2.8 km from South Mission Beach
8.6 out of 10, Excellent, (1111)
"Great place to vacation. "
United States
Manuel
The price is 3.768.308 ₫
5.737.250 ₫ total
includes taxes & fees
18 Jan - 19 Jan 2026
Catamaran Resort and Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in South Mission Beach

Find the best South Mission Beach areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Gaslamp Quarter featuring a bar, night scenes and street scenes

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Lyceum Theatre – discover Gaslamp Quarter, a destination also famous for its shopping.

Pacific Beach Park showing a beach

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Belmont Park featuring a park and rides

Mission Beach

If you're spending some time in Mission Beach, Mission Beach and Mission Bay are top sights worth seeing.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top South Mission Beach Hotel Reviews

The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

10/10 Excellent
"The room was comfortable & the staff was incredibly friendly. The location is also ideal for exploration and looking around. Really solid pick."
Michael 5-night trip
Posted 1 day ago
The DEXTRO Little Italy, BW Premier Collection

Frequently asked questions

What's it like in South Mission Beach?
Guests are sure to enjoy their time checking out all that San Diego's South Mission Beach neighbourhood has to offer. Experience the best of South Mission Beach with a visit to Mission Beach and Mission Bay during your trip.
How many hotels are there in South Mission Beach?
If you're searching for places to stay in San Diego, Expedia has something to meet your needs with 319 South Mission Beach hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Mission Beach, will I receive a refund?
Yes! Most hotel reservations are fully refundable if you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you have a non-refundable reservation, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Add dates, click "Search", then use the filter option "fully refundable" to get the best options available in South Mission Beach.
What is there to do in this San Diego neighbourhood?
Enjoy a stroll along the shore at Mission Beach, Mission and Pacific Beaches and South Mission Beach while you're in South Mission Beach. You could also plan a visit to Mission Bay or Belmont Park while you're in the neighbourhood. Golf Gardens Miniature Golf, Dog Beach and Bahia Point Beach are just a few of the places to visit in and around South Mission Beach. While you're out sightseeing in San Diego, make sure that you visit other sights such as Ocean Beach Athletic Area or Ocean Beach.