The Best Hotels Closest to South Texas Medical Center in San Antonio - 2026 Updated Prices

A modern medical building with reflective glass windows and a clear sky.

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Our top choices for South Texas Medical Center hotels

A spacious lobby with multiple seating areas, a central coffee table, and a view of the upper floors.

A modern lobby with a grey sofa, blue armchairs, and a stone accent wall.

A spacious indoor area with a long wooden reception desk, multiple seating arrangements, and large windows providing natural light.

An indoor swimming pool with multiple lanes, safety signs, and a view of the outside through large windows.

1. Drury Inn & Suites San Antonio Northwest Medical Center

Medical Center District, 2.9 km from South Texas Medical Center

Jennifer

2.329.391 ₫

2.773.956 ₫ total

includes taxes & fees

5 Nov - 6 Nov

A modern living room with a fireplace, a flat-screen TV, and a stone accent wall.

A modern cafe with wooden furniture, white tables, and a brick wall.

A Fairfield by Marriott Inn & Suites building with a modern design, featuring a prominent entrance with a covered walkway and a parking lot in front.

A reception area with a wooden reception desk, a 'Corner Market' sign, and a refrigerator stocked with beverages.

2. Fairfield Inn & Suites by Marriott San Antonio Medical Center

Medical Center District, 1 km from South Texas Medical Center

Tiffany

2.238.535 ₫

2.613.489 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A modern bar area with wooden bar counters, black bar stools, and pendant lighting.

A modern hotel lobby with a mix of seating arrangements, including round tables and sofas, and a bar area with a high counter.

A hotel entrance with a covered walkway, a wet driveway, and a tree in the foreground.

A hotel room with a large bed, a desk, and a chair.

3. Courtyard by Marriott Medical Center San Antonio

Medical Center District, 1.3 km from South Texas Medical Center

Francisca

2.306.354 ₫

2.746.521 ₫ total

includes taxes & fees

30 Oct - 31 Oct

A hotel dining area with multiple tables and chairs, a counter with a coffee machine, and a view of the outside through large windows.

A hotel lobby with a reception desk, seating area, and a chandelier.

A gym with multiple cardio machines, including treadmills and elliptical trainers, arranged in a spacious room with a carpeted floor and neutral-colored walls.

An outdoor patio area with tables and chairs, red umbrellas, and potted plants.

4. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

Medical Center District, 2.4 km from South Texas Medical Center

Gilbert

2.298.588 ₫

2.737.339 ₫ total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with two beds, a desk, a chair, a mirror, and a bathroom.

A laundry facility with multiple washing machines, a drying rack, and instructional posters on the wall.

A compact kitchen with a built-in refrigerator, microwave, and coffee maker.

A stone facade with a 'welcome' sign, a blue door, and a parking sign.

5. Studio 6 San Antonio, Tx - Northwest Medical Center

Medical Center District, 2.7 km from South Texas Medical Center

Ruben

1.238.338 ₫

1.445.936 ₫ total

includes taxes & fees

26 Oct - 27 Oct

A modern kitchen with a large window, wooden counter, and two bar stools.

A reception desk with a modern design, featuring a white counter and dark cabinets. There are three pendant lights above the desk, and a large window with a view of greenery outside.

A compact kitchenette with a built-in microwave, a black refrigerator, and a wooden countertop.

A hotel room with two beds, a bedside table with a phone, a window with curtains, and a wooden floor.

6. Park Inn by Radisson, Medical Center

Medical Center District, 1 km from South Texas Medical Center

Jaime

1.738.178 ₫

2.029.322 ₫ total

includes taxes & fees

8 Nov - 9 Nov

A building entrance with a glass door, a Pepsi vending machine, and a yellow bollard.

A hotel room with two beds, a television, a desk with a computer, and a door.

A hotel reception area with a glass door entrance, a reception desk, and a wall-mounted sign for the OYO hotel.

A hotel with a prominent 'OYO INN & SUITES' sign, featuring a two-story structure with balconies and a covered entrance.

7. OYO Inn & Suites Medical Center San Antonio

Medical Center District, 3.1 km from South Texas Medical Center

Melanie

A gas station with a sign for 'Atria Inn & Suites' and a 'Clearance - 12' sign.

A modern bathroom with a white sink, large mirror, and towel rack.

A hotel room with a bed, two bedside tables with lamps, a desk with a telephone, a mirror, and a door leading to another room.

A hotel entrance with an Atria Inn & Suites sign, a Classic Collins store, and a clear sky.

8. Atria Inn & Suites

Medical Center District, 2.2 km from South Texas Medical Center

Jose Rolando

1.574.584 ₫

1.838.327 ₫ total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with two beds, a TV, a desk, and a kitchenette in the background.

A modern room with a mounted flat-screen TV, a desk with a lamp, and built-in shelving.

A vending machine with various snack options.

A compact kitchen with a refrigerator, microwave, coffee maker, and a sink.

9. Studio 6 Extended Stay - San Antonio, TX - Medical Center

Medical Center District, 1.3 km from South Texas Medical Center

Jerron

1.345.761 ₫

1.654.310 ₫ total

includes taxes & fees

19 Oct - 20 Oct

A reception area with a glass door entrance, a reception desk, and a wall-mounted fire extinguisher.

A small, modern room with two brown leather sofas, a black cabinet, and a window with blinds.

A small, modern room with a wooden dining table, a mirror, a TV, and a small kitchenette.

A hotel room with a bed, bedside table, desk, chair, TV, and a wardrobe.

10. Motel 6 San Antonio, TX - Fiesta Trails

2.9 km from South Texas Medical Center

Cynthia

1.164.566 ₫

1.359.739 ₫ total

includes taxes & fees

19 Oct - 20 Oct

A hotel room with a large bed, a desk with a chair, a television on a stand, and a mirror on the wall.

A building with a red roof and a sign reading "Flex Studios."

A building with a yellow facade and a sign reading "Flex Studios."

A bathroom with a granite countertop sink, a mirror, a shower with a glass door, and a toilet.

11. Flex Studios

Medical Center District, 2.7 km from South Texas Medical Center

Jasper

1.138.940 ₫

1.356.307 ₫ total

includes taxes & fees

19 Oct - 20 Oct

A modern bedroom with a large bed, bedside tables, a desk, and a chair.

A swimming pool with a stone wall and a 'No Diving' sign, surrounded by a fence and a building with a stone facade.

A building with a stone facade, a prominent '6' sign, and a parking lot with marked handicapped spaces.

A hotel reception area with a large number '6' sign, a poster advertising direct booking, and a view of the outside through a window.

12. Motel 6 San Antonio, TX - Northwest Medical Center

Medical Center District, 2.8 km from South Texas Medical Center

robert

1.217.775 ₫

1.553.728 ₫ total

includes taxes & fees

23 Oct - 24 Oct

An indoor swimming pool with a hot tub, tiled flooring, and a seating area with tables and chairs.

A hotel lobby with a curved reception desk, a seating area with a sofa and chairs, and a hallway leading to other rooms.

A multi-story hotel with a central atrium, a parking lot, and surrounding greenery.

An outdoor patio area with multiple tables and chairs, covered by a pergola structure.

13. Drury Inn & Suites Near La Cantera Parkway

La Cantera District, 9 km from South Texas Medical Center

susan

2.432.931 ₫

2.897.256 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A Holiday Inn Express reception desk with a modern design, featuring a large illuminated sign, a reception area, and a potted plant.

A hotel room with a brick wall, a wooden headboard, two beds with white bedding, a bedside table with a lamp, and a wall-mounted light fixture.

A conference room with a long table, multiple chairs, and large windows offering a view of greenery and buildings.

A Holiday Inn Express building with a modern design, large windows, and a covered entrance area.

14. Holiday Inn Express San Antonio-Airport by IHG

9.2 km from South Texas Medical Center

Liz

2.717.925 ₫

3.236.641 ₫ total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with seating areas, a stone accent wall, and a wooden ceiling.

A reception desk with a computer, framed pictures on the wall, and pendant lighting.

A hotel entrance with a covered walkway, brick facade, and a sign indicating it is a Heritage Inn & Suites.

An outdoor patio with a pergola, pool, and outdoor seating area.

15. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

Uptown Central, 9.5 km from South Texas Medical Center

Amy

2.046.209 ₫

2.436.814 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel with a prominent sign reading "LA QUINTA".

A modern lounge area with wooden and colorful seating, a round table, and a flat-screen TV on the wall.

A modern bar area with wooden stools and a marble table, surrounded by seating with patterned cushions.

A modern kitchen with a large window, a counter with various appliances, and a view of the parking lot.

16. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

9.1 km from South Texas Medical Center

Yekaterine

2.821.465 ₫

3.294.060 ₫ total

includes taxes & fees

19 Oct - 20 Oct

A building with a large arched doorway, a balcony with a railing, and a tree with green foliage in the foreground.

A multi-story building with balconies and a white exterior.

A spacious dining area with multiple tables and chairs, each set with white cups and blue napkins.

A building with a white facade, black balconies, and a patio area with white wicker chairs and a small table.

17. Estancia del Norte San Antonio, Tapestry Collection by Hilton

8.7 km from South Texas Medical Center

Lareina

3.268.758 ₫

3.892.599 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A modern bar area with seating and a staircase leading to an upper level.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

A modern building with "EMBASSY SUITES" signage, featuring a prominent entrance and landscaped surroundings.

A spacious indoor dining area with multiple tables and chairs, a high ceiling with recessed lighting, and a view of the restaurant kitchen through a glass partition.

18. Embassy Suites by Hilton San Antonio Airport

Uptown Central, 9.6 km from South Texas Medical Center

Trenton

3.268.758 ₫

3.892.599 ₫ total

includes taxes & fees

1 Nov - 2 Nov

A modern kitchen with a large flat-screen TV, a glass display case with wine glasses, and a breakfast buffet sign.

A modern kitchen with a large island, bar stools, and a television displaying a football game.

A modern living room with a sofa, two armchairs, a coffee table, and a TV.

An outdoor patio area with a barbecue grill, seating arrangements, and potted plants.

19. Staybridge Suites San Antonio Lackland AFB Area by IHG

Far West Side, 9.8 km from South Texas Medical Center

"We had a wonderful stay! The hotel was very clean, and our room was spacious, spotless, and comfortable. The bed was incredibly comfortable, just like sleeping at home! And the pillows were surprisingly great for hotel pillows. I actually brought my own pillow but ended up using theirs because I liked them better! Breakfast was good, and the staff was always friendly, welcoming, and accommodating. Overall, a great experience, and I would definitely stay here again!"

Sheena

3.598.015 ₫

4.200.618 ₫ total

includes taxes & fees

25 Oct - 26 Oct

An outdoor courtyard with a pool table, lounge chairs, and string lights.

A courtyard with outdoor seating, a fire pit, and string lights.

A swimming pool surrounded by palm trees and a fence, with string lights in the background.

A modern lobby with a sofa, chairs, a small table, and a TV screen.

20. Residence Inn by Marriott San Antonio Six Flags at The Rim

La Cantera District, 10.4 km from South Texas Medical Center

Glenda

3.287.395 ₫

3.914.794 ₫ total

includes taxes & fees

9 Nov - 10 Nov

View all properties

Compare popular hotels close to South Texas Medical Center

Property	Property class	Guest rating
Drury Inn & Suites San Antonio Northwest Medical Center	9.2 Wonderful 1,503 reviews	View
Fairfield Inn & Suites by Marriott San Antonio Medical Center	9.0 Wonderful 1,102 reviews	View
Courtyard by Marriott Medical Center San Antonio	8.8 Excellent 1,002 reviews	View
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW	8.4 Very good 3,722 reviews	View
Studio 6 San Antonio, Tx - Northwest Medical Center	7.4 Good 394 reviews	View

Top South Texas Medical Center Hotel Reviews

Drury Inn & Suites San Antonio Northwest Medical Center

10/10 Excellent

"Staff was friendly, breakfast and dinner were free and extremely good, loved our stay here. Highly recommend!"

Sonesta ES Suites San Antonio Northwest - Medical Center

10/10 Excellent

"Just about everything was great at this hotel with the exception of two things. We had the 2 bedroom suite: each bedroom with its own restroom. It had a nice living room and a small kitchenette. Very nice suite. First issue was that there was no hot water in the showers. Very disappointing to shower with cold water. Second issue was constantly having to go to the front desk to get the room key to work. So every time we left the room the key would no longer work to get back in. That was a pain to deal with."

Fairfield Inn & Suites by Marriott San Antonio Medical Center

8/10 Good

"Convenient but the rooms felt rather tight."

Park Inn by Radisson, Medical Center

8/10 Good

"It was close to were we needed to go."

Studio 6 Extended Stay - San Antonio, TX - Medical Center

8/10 Good

"Tiene todos los servicios como estufa refrigerador, mesa. Naño y cama."

Motel 6 San Antonio, TX - Northwest Medical Center

8/10 Good

"Inexpensive. Above expectations. Quiet, cool, staff friendly."

Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

10/10 Excellent

"I was expecting a little but more updated for what I paid but the stay was nice"

Homewood Suites by Hilton San Antonio Northwest

10/10 Excellent

"Very clean room, staff helpful and friendly. Good food assortment for breakfast."

Frequently asked questions

What's the area like around South Texas Medical Center?

South Texas Medical Center is located in a walkable area of San Antonio known for its stunning river views and cycling. If you're looking for a convenient place to stay, take a look at the 35 hotels and other accommodation options you'll find within a mile.

How many hotels should I expect to find close to South Texas Medical Center?

Expedia has 35 hotels and other accommodation options within a mile from South Texas Medical Center.

If I need to cancel the hotel reservation for my stay near South Texas Medical Center, will I receive a refund?

Yes, you'll find most room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best deals near South Texas Medical Center.

What can I see and do near South Texas Medical Center?

You can watch performances at Woodlawn Theater, Sheldon Vexler Theatre and Laugh Out Loud Comedy Club if you're interested in local theatre. Create some family memories at Crystal Ice Palace and Monster Mini Golf. Looking for a little shopping break? A trip to Wonderland of the Americas Mall, Huebner Oaks and Ingram Park Mall might be just the ticket while you're in the area around South Texas Medical Center.

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Our top choices for South Texas Medical Center hotels

1. Drury Inn & Suites San Antonio Northwest Medical Center

2. Fairfield Inn & Suites by Marriott San Antonio Medical Center

3. Courtyard by Marriott Medical Center San Antonio

4. La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

5. Studio 6 San Antonio, Tx - Northwest Medical Center

6. Park Inn by Radisson, Medical Center

7. OYO Inn & Suites Medical Center San Antonio

8. Atria Inn & Suites

9. Studio 6 Extended Stay - San Antonio, TX - Medical Center

10. Motel 6 San Antonio, TX - Fiesta Trails

11. Flex Studios

12. Motel 6 San Antonio, TX - Northwest Medical Center

13. Drury Inn & Suites Near La Cantera Parkway

14. Holiday Inn Express San Antonio-Airport by IHG

15. Heritage Inn & Suites San Antonio Airport, Trademark Wyndham

16. La Quinta Inn & Suites by Wyndham San Antonio Seaworld/LAFB

17. Estancia del Norte San Antonio, Tapestry Collection by Hilton

18. Embassy Suites by Hilton San Antonio Airport

19. Staybridge Suites San Antonio Lackland AFB Area by IHG

20. Residence Inn by Marriott San Antonio Six Flags at The Rim

Compare popular hotels close to South Texas Medical Center

Top South Texas Medical Center Hotel Reviews

Drury Inn & Suites San Antonio Northwest Medical Center

Sonesta ES Suites San Antonio Northwest - Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Park Inn by Radisson, Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center

Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

Homewood Suites by Hilton San Antonio Northwest

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