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Check prices for these dates

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25 Sep - 27 Sep
Next weekend
2 Oct - 4 Oct

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Our top choices for Southampton hotels

A rooftop pool area with lounge chairs and a view of a tall building at night.

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 1.6 km from Southampton
9.2 out of 10, Wonderful, (1,208 reviews)
"great location and the hotel is quite comfortable"
United States
Juan
The price is 3.761.379 ₫
4.681.788 ₫ total
includes taxes & fees
27 Sept - 28 Sept
The Westin Houston Medical Center/Museum District
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

2. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3 km from Southampton
9.2 out of 10, Wonderful, (2,677 reviews)
"Everything was great, a wonderful place to stay with the family."
United States
Jorge
The price is 3.304.540 ₫
3.886.801 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Hyatt Place Houston Medical Center
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

3. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 1.5 km from Southampton
8.6 out of 10, Excellent, (2,162 reviews)
"Beautiful Hotel and excellent Service"
United States
olga
The price is 2.751.867 ₫
3.249.862 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Hilton Houston Plaza/Medical Center
A person sitting on a white lounge chair with a striped towel, reading a book.

4. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
Greenway Plaza-Upper Kirby, 1.5 km from Southampton
7.8 out of 10, Good, (1,657 reviews)
"Super clean and the staff is very attentive"
United States
Amehed
The price is 1.743.005 ₫
2.039.316 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Crowne Plaza Houston Med Ctr-Galleria Area by IHG
A modern living room with a glass table, a sofa, a TV, and a staircase with a city view.

5. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby, 2.4 km from Southampton
8.4 out of 10, Very good, (1,898 reviews)
"Excellent location, clean hotel room and the staff are absolutely wonderful."
Australia
Chloe
The price is 2.758.131 ₫
3.227.014 ₫ total
includes taxes & fees
12 Oct - 13 Oct
DoubleTree by Hilton Hotel Houston - Greenway Plaza
A spacious hotel lobby with high ceilings, large windows, a long bar area, and a seating area with a sofa and chairs.

6. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3 km from Southampton
9.2 out of 10, Wonderful, (1,285 reviews)
"Overall experience was very good, location, cleanliness and great breakfast."
United States
Gaby
The price is 3.493.376 ₫
4.108.912 ₫ total
includes taxes & fees
12 Oct - 13 Oct
Hyatt House Houston Medical Center
A spacious indoor area with multiple seating arrangements, including tables and chairs, and large windows providing natural light.

7. La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
25.7 km from Southampton
8.0 out of 10, Very good, (2,704 reviews)
"The breakfast was really good and the staff gently"
United States
nelson
The price is 2.037.366 ₫
2.383.718 ₫ total
includes taxes & fees
24 Sept - 25 Sept
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
A modern indoor pool area with a wooden table and chairs, a vase with flowers, and a view of the outside buildings.

8. Best Western Plus Downtown Inn & Suites

Best Western Plus Downtown Inn & Suites
3.0 star property
5 km from Southampton
9.2 out of 10, Wonderful, (1,126 reviews)
"Clean rooms, friendly staff, and great breakfast."
United States
ROMAN
The price is 3.024.244 ₫
3.538.366 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Best Western Plus Downtown Inn & Suites
A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

9. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 2.7 km from Southampton
9.0 out of 10, Wonderful, (3,870 reviews)
"Friendly staff, central location, and beautiful hotel."
United States
Angela
The price is 4.245.128 ₫
4.983.191 ₫ total
includes taxes & fees
18 Oct - 19 Oct
Blossom Hotel Houston, Curio Collection by Hilton
A bar area with a long counter, bar stools, a refrigerated display case with beverages, and a menu board above the counter.

10. Courtyard By Marriott Houston Medical Center Reliant Park

Courtyard By Marriott Houston Medical Center Reliant Park
3.0 star property
2.9 km from Southampton
8.6 out of 10, Excellent, (1,006 reviews)
"Great Hotel!"
United States
Jorge
The price is 2.903.274 ₫
3.431.982 ₫ total
includes taxes & fees
25 Sept - 26 Sept
Courtyard By Marriott Houston Medical Center Reliant Park
A modern restaurant with a bar area, wooden flooring, and a variety of seating options including tables and chairs.

11. Hotel Ylem

Hotel Ylem
3.5 star property
3.2 km from Southampton
8.4 out of 10, Very good, (1,569 reviews)
"Great atmosphere"
United States
William Bryan
The price is 1.736.835 ₫
2.162.196 ₫ total
includes taxes & fees
24 Sept - 25 Sept
Hotel Ylem
A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

12. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 5.3 km from Southampton
8.8 out of 10, Excellent, (2,271 reviews)
"Great stay!"
United States
Dr. Zurick
The price is 3.746.160 ₫
4.383.007 ₫ total
includes taxes & fees
25 Sept - 26 Sept
The Royal Sonesta Houston Galleria
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

13. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG

Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
2.5 star property
4.4 km from Southampton
9.4 out of 10, Exceptional, (1,000 reviews)
"I’ll stay again"
United States
Kevin
The price is 3.070.360 ₫
3.613.397 ₫ total
includes taxes & fees
5 Oct - 6 Oct
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
A modern hotel building with a sign reading "SPRINGHILL SUITES BY MARRIOTT".

14. SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
26.4 km from Southampton
9.0 out of 10, Wonderful, (1,888 reviews)
"Great room at a great price."
United States
James
The price is 2.631.417 ₫
3.078.758 ₫ total
includes taxes & fees
23 Oct - 24 Oct
SpringHill Suites by Marriott Houston Intercontinental Arprt
A modern bar area with multiple shelves of liquor bottles, a central bar counter, and seating with tables and chairs.

15. The Chifley Houston, Tapestry Collection by Hilton

The Chifley Houston, Tapestry Collection by Hilton
4.0 star property
The Galleria, 5.2 km from Southampton
9.2 out of 10, Wonderful, (1,378 reviews)
"Great place to stay in Houston, super friendly front staff!"
United States
Fouad
The price is 3.605.159 ₫
4.218.037 ₫ total
includes taxes & fees
2 Oct - 3 Oct
The Chifley Houston, Tapestry Collection by Hilton
A multi-level atrium with a central water feature, glass railings, and outdoor seating areas.

16. Hyatt Regency Houston West

Hyatt Regency Houston West
3.5 star property
21.4 km from Southampton
8.6 out of 10, Excellent, (1,656 reviews)
"Staff was very friendly"
United States
Massiel
The price is 2.581.184 ₫
3.019.985 ₫ total
includes taxes & fees
29 Sept - 30 Sept
Hyatt Regency Houston West
A hotel lobby with a hot tub, a pool, and a dining area.

17. Drury Inn & Suites Houston Near the Galleria

Drury Inn & Suites Houston Near the Galleria
3.0 star property
The Galleria, 5.4 km from Southampton
9.4 out of 10, Exceptional, (1,555 reviews)
"Great location, wonderful breakfast"
United States
Andrei
The price is 2.445.150 ₫
2.860.824 ₫ total
includes taxes & fees
27 Sept - 28 Sept
Drury Inn & Suites Houston Near the Galleria
A modern living room with a blue sofa set, patterned cushions, and a central wooden coffee table.

18. Sonesta ES Suites Houston Galleria

Sonesta ES Suites Houston Galleria
3.0 star property
The Galleria, 5.6 km from Southampton
8.4 out of 10, Very good, (1,382 reviews)
"Great staff and location !"
United States
Melissa
The price is 2.836.180 ₫
3.318.331 ₫ total
includes taxes & fees
24 Sept - 25 Sept
Sonesta ES Suites Houston Galleria
A dining table with white tablecloth, two plates of food, two wine glasses, and a vase with white flowers.

19. Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 6.1 km from Southampton
8.6 out of 10, Excellent, (4,509 reviews)
"Cozy hotel to stay in"
United States
Alfredo
The price is 2.542.966 ₫
2.975.271 ₫ total
includes taxes & fees
25 Sept - 26 Sept
Club Quarters Hotel Downtown, Houston
A modern outdoor patio area with stone walls, a fire pit, and outdoor seating.

20. Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
26.4 km from Southampton
9.0 out of 10, Wonderful, (1,349 reviews)
"Great hotel close to the airport. Friendly staff and the rooms were clean."
United States
Leah
The price is 2.631.923 ₫
3.079.349 ₫ total
includes taxes & fees
25 Sept - 26 Sept
Courtyard by Marriott Houston Intercontinental Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Southampton

Find the best Southampton areas for the activities you enjoy most.
A sculpture garden with abstract art pieces in a city park.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Daikin Park to Toyota Center – discover Downtown Houston, a destination also famous for its sports teams.

A person walking in front of a building with a brick facade and three arched windows.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

A modern building with a covered outdoor area and a circular garden feature.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Top Southampton Hotel Reviews

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

10/10 Excellent
"No one was at the desk in the morning lack of ownership"
BRADLEY 1-night trip
Posted 1 hour ago
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Frequently asked questions

What is Southampton like?
Travellers will be sure to enjoy their time in Houston's Southampton neighbourhood.
If I need to cancel my hotel reservation in Southampton, will I receive a refund?
Yes, you'll find most room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view top deals in Southampton.
What can I see and do in this Houston neighbourhood?
A few places to visit in the area around Southampton include Reliant Stadium, Twilight Epiphany Skyspace and Rice Stadium. When you're sightseeing in Houston, Anderson Clarke Center and Main Street Theater - Rice Village are also worth a stop.