Southern Indiana Holidays

Book a Hotel + Flight or Car together to unlock savings

Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
The entrance to the Kentucky Science Center with a large circular structure in the foreground.

West Main Historic District

A noteworthy feature of West Main Historic District is its fantastic nightlife. While you're in town, be sure to stop and check out Louisville Slugger Museum and Louisville Science Center.

Find hotels in West Main Historic District

Top hotels in Southern Indiana

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive Clarksville IN
Fully refundableReserve now, pay when you stay
The price is 1.743.332 ₫ per night from 20 Jul to 21 Jul
1.743.332 ₫
1.969.913 ₫ total
20 Jul - 21 Jul
includes taxes & fees
7/10 Good! (3,244 reviews)
"The room was OK for one night but I wouldn’t stay any longer it was a last minute trip"

Reviewed on 14 Jul 2026

Radisson Hotel Louisville North
Santas Lodge and Resort

Santas Lodge and Resort

2.5 out of 5
91 W CHRISTMAS BLVD Santa Claus IN
Fully refundableReserve now, pay when you stay
The price is 3.237.005 ₫ per night from 14 Aug to 15 Aug
3.237.005 ₫
3.625.445 ₫ total
14 Aug - 15 Aug
includes taxes & fees
8/10 Very good! (359 reviews)
"If you love Christmas, you'll love this lodge! It really puts you in the holiday spirit. My grandson especially loved the fishing pond, and we all had a great time in the arcade. The lodge is a bit dated, and the beds weren't very comfortable, but the friendly staff and the great breakfast helped ..."

Reviewed on 14 Jul 2026

Santas Lodge and Resort
Derby Hotel & Suites

Derby Hotel & Suites

2 out of 5
505 K Marriot Dr Clarksville IN
Fully refundable
The price is 1.525.415 ₫ per night from 20 Jul to 21 Jul
1.525.415 ₫
1.723.719 ₫ total
20 Jul - 21 Jul
includes taxes & fees
6.8/10 (122 reviews)
"The bathroom was not clean at all. Tub was filthy. Stains all the sheets. Was supposed to be two queen bed suite and we got full size beds not nowhere near a suite! Most horrible experience! Will never be back"

Reviewed on 13 Jul 2026

Derby Hotel & Suites
See all 1,563 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Southern Indiana attractions

A water slide with a yellow and green inflatable raft carrying three people.
Photo by Indiana Office of Tourism Development
Open Photo by Indiana Office of Tourism Development

Holiday World and Splashin' Safari

9.4/10 (294 reviews)
Holiday World features themed holiday areas with thrilling coasters and water attractions. Enjoy complimentary soft drinks and sun cream while experiencing the world's longest water coaster, Wildebeest.
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Frequently asked questions

How much does a Southern Indiana holiday package cost?
We make it simple to travel somewhere new, with Southern Indiana holiday packages starting from just . You'll have the flexibility to combine your preferred airlines, hotels and car rental. For the ultimate escape, why not add a few activities and tours to your itinerary?
How do I get a cheap travel package to Southern Indiana?
If you love bargains, combine your bookings into a Southern Indiana holiday package. Whether you're looking for flights, hotels, day tours or rental cars, you can book everything in one place. You'll have plenty of choice at your fingertips too. Expedia has over 550 airlines and 1null000null000 hotels around the globe to take your pick of. Fly with who you want, stay where you like and save a packet — now that's the ideal getaway!
Where should I stay in Southern Indiana?
Louisville is a fantastic place to explore. It draws in many travellers who come to see its top sights, like Churchill Downs and Muhammad Ali Centre.
What are the top hotels in Southern Indiana?
When it comes to properties in Louisville, Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville are two fantastic options. If you're also spending time in Jeffersonville - Clarksville, Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis look forward to welcoming you.
How far in advance should I book my Southern Indiana holiday?
It all depends on the airline, but you can normally browse through international airfares on Expedia up to a year in advance. While it's a good idea to book ahead of time, lucky travellers will sometimes score a cheaper seat only weeks before the date of departure.
What does an Expedia Southern Indiana travel package include?
With Expedia, you can select any combination of flights, car rentals and hotels to create your ideal Southern Indiana travel package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the greater the savings!
What should I know before booking a Southern Indiana travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fabulous discounts. Hotels aren't your only choice, though. Book with us and select from island resorts, rural cottages and everything in between!
Can I choose my airline with a Southern Indiana Expedia holiday package?
Expedia offers access to more than 550 partner airlines globally, so you certainly can. Simply select the carrier that suits you and create the perfect Southern Indiana trip.
If I'm not able to travel, can I cancel my Southern Indiana holiday package?
Yes, you can. We understand that even the best-laid plans can go awry, so we're here to help if you have to make changes to your Southern Indiana holiday package. You may be able to amend or cancel your itinerary at no cost if you've booked in the last 24 hours. Your hotel, airline or car rental company may impose a fee if your booking was made more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.

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