Compare and book 4 Star hotels in Big Pine Key, Florida

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Check availability on Big Pine Key 4 Star Hotels

Tonight
28 Apr - 29 Apr
Tomorrow
29 Apr - 30 Apr
This weekend
1 May - 3 May
Next weekend
8 May - 10 May

Our top choices for Big Pine Key 4-star hotels

2 bars/lounges, poolside bar

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,159 reviews)
"The room was clean, all staff was friendly, lots of shopping close by, the food at the restaurant was delicious. Would stay there again!"
United States
Jennifer
The price is 5.529.048 ₫
7.211.617 ₫ total
includes taxes & fees
21 May - 22 May
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
3 outdoor pools, pool loungers

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,000 reviews)
"Amazing resort "
United States
Joy
The price is 8.409.962 ₫
11.185.882 ₫ total
includes taxes & fees
19 May - 20 May
Tranquility Bay Beachfront Hotel and Resort
Balcony view

Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (435 reviews)
"Amazing views, hospitality and food!"
United States
kevin
The price is 6.876.594 ₫
9.000.823 ₫ total
includes taxes & fees
29 May - 30 May
Grassy Flats Resort & Beach Club
Exterior

The Reef at Marathon, Florida Keys

The Reef at Marathon, Florida Keys
4.0 star property
Marathon
9.2 out of 10, Wonderful, (25 reviews)
"Great location! "
United States
Ricardo
The Reef at Marathon, Florida Keys
Exterior

Marlin Bay Resort & Marina

Marlin Bay Resort & Marina
4.5 star property
Marathon
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful vacation!"
United States
Chardell
Marlin Bay Resort & Marina
Luxury Villa, 3 Bedrooms, Balcony, Overwater | Terrace/patio

Waterfront Luxury Villa

Waterfront Luxury Villa
4.0 star property
Marathon Shores
Waterfront Luxury Villa
Outdoor pool

Indigo Reef Marina Pet Friendly Homes by Pack and Relax

Indigo Reef Marina Pet Friendly Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Pet Friendly Homes by Pack and Relax
Villa, 3 Bedrooms | Property grounds

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax

Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
4.0 star property
Marathon Shores
Indigo Reef Marina Homes Close to Boat Slip by Pack and Relax
Outdoor pool

Indigo Reef Marina Homes by Pack and Relax

Indigo Reef Marina Homes by Pack and Relax
4.0 star property
Marathon
Indigo Reef Marina Homes by Pack and Relax
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Big Pine Key.
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

1 Knights Key Boulevard Marathon FL
The price is 7.564.224 ₫ per night from 10 May to 11 May
7.564.224 ₫
10.158.021 ₫ total
10 May - 11 May
includes taxes & fees
9.2/10 Wonderful! (1,135 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Big Pine Key

Snorkel crystal-clear waters teeming with colourful fish, then spot adorable Key deer at the National Key Deer Refuge. Unwind on pristine beaches like Calusa or Sandspur, where soft sand meets turquoise waves.

See all hotels in Big Pine Key

Top Big Pine Key Hotel Reviews

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

10/10 Excellent
"My hubby and I absolutely loved this place. The pool was super warm and huge! My only complaint was not for the resort or its employees, but in the other guests that ignored the policies of no smoking and no glass in the pool area. Super frustrating to smell cigarette smoke all afternoon in the pool area and the guests that were so disrespectful to the other guests by continuing to smoke. The guy that dropped his glass bottle at least picked it up but, I am sure there will be some small shards that may cut someone. I am not trying to be a karen but, seriously, follow the rules!"
amalia 2-night trip
Posted 2 days ago
Tranquility Bay Beachfront Hotel and Resort
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent
"It’s all about the Molton Brown. It truly elevated the entire experience and made it feel like a 5-star hotel."
Warren 2-night trip
Posted 2 days ago
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Frequently asked questions

What are the best 4-star hotels in Big Pine Key?
Create unforgettable holiday memories in Big Pine Key at Little Palm Island Resort & Spa - A Noble House Resort. A favourite with our guests, this 4-star hotel offers loads of conveniences for a relaxing and comfortable stay.
How much does it cost to stay in a 4-star hotel in Big Pine Key?
To find a 4-star hotel in Big Pine Key that fits your budget, use Expedia's handy filters. Take a look at the available options during your holiday dates and use our pricing filter to set your limit. You can also list your results by the most budget-friendly stay first.

  • Search for the lowest price from 10.158.021 ₫

What's the difference between 5-star and 4-star hotels in Big Pine Key?
Treat yourself to luxury living during your Big Pine Key getaway by checking in to a 4-star hotel. As well as featuring upscale accommodation, these retreats are usually packed with amenities like large beds, complimentary bathrobes and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and unforgettable one. 24-hour concierge assistance, elegant furnishings and world-class dining are only the start of the exclusive services and conveniences you'll likely have access to.