Compare and book 5 Star hotels in St. Louis, Missouri
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on St. Louis 5 Star Hotels
Tonight
17 Sep - 18 SepTomorrow
18 Sep - 19 SepThis weekend
18 Sep - 20 SepNext weekend
25 Sep - 27 SepOur top choices for St. Louis 5-star hotels
9.744.750 ₫
11.394.341 ₫ total
includes taxes & fees
20 Sept - 21 Sept
14.266.314 ₫
16.654.687 ₫ total
includes taxes & fees
20 Sept - 21 Sept
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in St. Louis.
Renaissance St. Louis Airport Hotel
9801 Natural Bridge Road St. Louis MO
2.889.643 ₫
3.380.535 ₫ total
2 Oct - 3 Oct
includes taxes & fees
Hyatt Regency St. Louis at The Arch
315 Chestnut St St. Louis MO
3.952.471 ₫
4.661.110 ₫ total
1 Oct - 2 Oct
includes taxes & fees
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
3.732.889 ₫
4.494.760 ₫ total
11 Oct - 12 Oct
includes taxes & fees
9/10 Wonderful! (2,112 reviews)
Still don't see what you're looking for?
See all properties in St. Louis.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
St. Louis and related destinations
The Gateway Arch towers 630 feet above the Mississippi, with a tram that takes you to spectacular views at the top. Explore Forest Park's free museums, catch a Cardinals game at Busch Stadium, and don't miss Ted Drewes' frozen custard that locals swear by.
See all hotels in St. Louis
Top St. Louis Hotel Reviews
Frequently asked questions
What are the best 5-star hotels in St. Louis?
Treat yourself to a luxurious stay at Four Seasons Hotel St Louis. This is among the top 5-star hotels in St. Louis based on Expedia customer reviews. From its guest services to its well-appointed rooms and prime location, you can rely on the highest standard of excellence.
How much does it cost to stay in a 5-star hotel in St. Louis?
You'll find many different pricing options for a 5-star hotel in St. Louis on Expedia. The amount you pay will depend on your travel dates, trip length and other factors. Compare available accommodation for your desired dates and use our pricing and other filters to lock in the ideal high-end stay.
- Search for the lowest price per night from 3.380.535 ₫
What makes a hotel 5 stars in St. Louis?
From gourmet dining venues and 24/7 fitness centres to pools and the finest bedding, the 5-star experience in St. Louis is all about indulgence and comfort. But it takes more than just upscale perks to earn a 5-star rating. Accommodation must also deliver remarkable guest-focused services like in-room massage treatments, on-site dry cleaning and laundry and a nightly turn-down service.