Find hotels in Cairo, IL from 1.540.853 ₫

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Top 10 Cairo hotels and places to stay

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (264)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is 1.815.921 ₫
2.015.309 ₫ total
includes taxes & fees
8 Sept - 9 Sept
Quality Inn Cairo I-57

La Center Motel

2.0 star property
7.8 out of 10, Good, (14)
"Front desk staff was amazing. Room was comfy and quiet! Clean! Husband and I needed a place to crash on our long ride home and this motel did not disappoint!"
La Center Motel

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
The price is 1.675.891 ₫
1.860.058 ₫ total
includes taxes & fees
1 Sept - 2 Sept
Eagle Inn Charleston

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (582)
"Rooms was clean "
The price is 1.540.853 ₫
1.710.045 ₫ total
includes taxes & fees
8 Sept - 9 Sept
Super 8 by Wyndham Charleston/Sikeston East MO

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (397)
"I consistently choose to stay there due to positive past encounters."
The price is 1.767.580 ₫
1.961.572 ₫ total
includes taxes & fees
10 Sept - 11 Sept
Quality Inn Charleston - Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Accommodation near Cairo attractions

Fort Defiance State Park

Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area.

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

Top Cairo Hotel Reviews

Frequently asked questions

What's the seasonal weather like in Cairo?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.