An aerial view of a river winding through a dense, green forest.

Search Holiday Rentals in Madre de Dios Region

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Madre de Dios Region Accommodation: Most Popular Cities to Stay

A river winding through a dense forest under a cloudy sky.
Vacation RentalsVacation Rentals

Tambopata

Tambopata
A calm river with wooden docks and lush greenery in the background.
Vacation RentalsVacation Rentals

Manu

Manu

Our top choices for Madre de Dios Region holiday rentals

Exterior

1. Quirquincho House

Quirquincho House
3.0 star property
Tambopata
10.0 out of 10, Exceptional, (3 reviews)
"Property was well maintained, neat and clean. The owner was very friendly and made us feel home.would suggest if you want to stay in a quiet place surrounded by nature."
United States
VIJAY
The price is 1.261.810 ₫
1.807.036 ₫ total
2 Sept - 3 Sept
Quirquincho House
Superior Cabin, Garden View

2. Explorers Inn

Explorers Inn
2.0 star property
Tambopata
The price is 5.709.601 ₫
10.408.861 ₫ total
2 Sept - 3 Sept
Explorers Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Madre de Dios Region Hotel Reviews

IKAM Riverview Amazon Lodge - Asociado Casa Andina

IKAM Riverview Amazon Lodge - Asociado Casa Andina

8/10 Good
"The property was breathtaking I loved the immersion into the jungle feel mixed with urban necessities. The staff were friendly and the tour guides were knowledgeable."
Andrew 3-night trip
Posted 4 days ago
IKAM Riverview Amazon Lodge - Asociado Casa Andina

Explore a world of travel with Expedia