A rocky stream surrounded by trees and foliage.

Find the best Cape Girardeau County Hotels

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November 2026

5

December 2026

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Top cities in Cape Girardeau County

A nighttime view of a bridge with its cables illuminated against a starry sky.

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13 Nov - 15 Nov

Map of Cape Girardeau County

Our top choices for Cape Girardeau County hotels

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

United States

Chris

2.901.850 ₫ total

includes taxes & fees

10 Nov - 11 Nov

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

2. The Riverview

Cape Girardeau

United States

John

3.317.145 ₫ total

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

3. Pear Tree Inn Cape Girardeau West

Cape Girardeau

United States

Celeste

2.089.251 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

4. Drury Inn & Suites Cape Girardeau

Cape Girardeau

United States

Mary

2.611.636 ₫ total

includes taxes & fees

12 Nov - 13 Nov

A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

5. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

United States

J

2.224.487 ₫ total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

6. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Cape Girardeau

United States

Rebecca

2.781.473 ₫ total

includes taxes & fees

6 Dec - 7 Dec

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

7. Drury Inn & Suites Jackson MO

Jackson

United States

Leonardo

2.175.549 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

8. Quality Inn Cape Girardeau North

Cape Girardeau

United States

Dayanita

1.723.871 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

9. Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

United States

James

2.202.008 ₫ total

includes taxes & fees

22 Nov - 23 Nov

A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

10. Fairfield Inn & Suites by Marriott Cape Girardeau

Cape Girardeau

United States

Carlos

2.935.516 ₫ total

includes taxes & fees

12 Nov - 13 Nov

A modern retail area with a display of local items and snacks.

11. Tru By Hilton Cape Girardeau

Cape Girardeau

United States

Shannon

2.496.883 ₫ total

includes taxes & fees

12 Nov - 13 Nov

A spacious lobby with marble flooring, elegant seating, and a grand staircase.

12. Courtyard by Marriott Cape Girardeau Downtown

Cape Girardeau

United States

Jacqueline

3.384.320 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

13. Town House Inn Cape Giradreau

Cape Girardeau

United States

Jaime

2.103.533 ₫ total

includes taxes & fees

8 Nov - 9 Nov

A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

14. Hampton Inn Cape Girardeau I 55 East

Cape Girardeau

United States

Vonnie

2.831.909 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with large windows, comfortable seating, and a modern ceiling design.

15. Comfort Suites Jackson-Cape Girardeau

Jackson

United States

Jeff

2.096.697 ₫ total

includes taxes & fees

6 Dec - 7 Dec

A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.

16. Town House Inn

Jackson

United States

Jennifer

2.380.394 ₫ total

includes taxes & fees

6 Nov - 7 Nov

A rustic wooden cabin with a porch, outdoor seating, and a view of a lush green landscape.

17. Private Getaway on 270 Acres w/ Lake: Swim & Canoe

Advance

A spacious living area with a sofa, a coffee table, and a TV.

18. Deck & Large Yard! Family Haven in Cape Girardeau

Cape Girardeau

View all properties

Top Cape Girardeau County Hotel Reviews

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.

Urban Lofts

Perryville

10/10 Excellent

United Kingdom

David Lee

A hotel room with a large bathtub, a sofa, a small table, a TV, and a window with curtains.

Super 8 by Wyndham Perryville

Perryville

10/10 Excellent

This is one of the nicest Super 8 hotels I have stayed. Super 8 is always a great value, this Super 8 went to extra efforts though. Always had coffee bar available and fruits. It was nice to come in that evening and grab a coffee and apple after long day of travel. The room was clean, comfortable, and had pleasing decor. Breakfast was typical Super 8 fare, but staff did excellent job of ensuring there was always plenty available for all guests. I would return to this Super 8.

United Kingdom

Anonymous traveller

A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

Candlewood Suites Cape Girardeau by IHG

Cape Girardeau

10/10 Excellent

United Kingdom

Kathryn