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Santa Cruz Accommodation: Most Popular Cities to Stay

San Lorenzo Cathedral showing a garden
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Santa Cruz

Santa Cruz

Check prices for these dates

Tonight
22 Dec - 23 Dec
Tomorrow
23 Dec - 24 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Santa Cruz hotels

Seasonal outdoor pool
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (347)
"Great spacious property with nice pool!"
United States
Douglas
The price is 3.410.424 ₫
3.410.424 ₫ total
4 Jan - 5 Jan 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Outdoor pool, pool umbrellas, pool loungers
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (211)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is 2.926.228 ₫
2.926.228 ₫ total
2 Jan - 3 Jan 2026
Marriott Santa Cruz de la Sierra Hotel
Miscellaneous
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra
3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (76)
"Great Spot"
United States
Jose
The price is 1.023.127 ₫
1.023.127 ₫ total
24 Dec - 25 Dec
Ibis Santa Cruz DE LA Sierra
Outdoor pool
Sun Hotel

Sun Hotel

Sun Hotel
3.5 star property
Santa Cruz
8.4 out of 10, Very good, (331)
"Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok"
United States
Peter
The price is 2.358.877 ₫
2.358.877 ₫ total
26 Dec - 27 Dec
Sun Hotel
Reception
Camino Real Hotel

Camino Real Hotel

Camino Real Hotel
4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
The price is 4.736.700 ₫
4.736.700 ₫ total
25 Dec - 26 Dec
Camino Real Hotel
Outdoor pool, pool loungers
Hotel Cortez

Hotel Cortez

Hotel Cortez
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (124)
"The staff and property are second to none! "
United States
Cynthia
The price is 3.623.575 ₫
3.623.575 ₫ total
9 Jan - 10 Jan 2026
Hotel Cortez
Lobby sitting area
Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (104)
"Luxurious hotel,very chic and beautiful."
United States
Cristhian
The price is 2.631.500 ₫
2.631.500 ₫ total
6 Jan - 7 Jan 2026
Novotel Santa Cruz De La Sierra
Reception
HOTEL OSHO

HOTEL OSHO

HOTEL OSHO
3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (35)
"Hot tub worked well and room was very comfortable! 24 hr market across the street came in handy. The best hotel I've stayed at in Bolivia!"
United States
Robert
HOTEL OSHO
Lounge
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (256)
"Nice hotel "
United States
Narciso Lorenzo
The price is 1.936.784 ₫
1.936.784 ₫ total
25 Dec - 26 Dec
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
1 bedroom, in-room safe, desk, iron/ironing board
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz
3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz
Front of property
Chairú Eco Hotel

Chairú Eco Hotel

Chairú Eco Hotel
3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (48)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel
Outdoor pool, open 9:00 AM to 8:00 PM, pool loungers
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (81)
"Good price, great hotel!"
United States
James
The price is 1.026.285 ₫
1.026.285 ₫ total
24 Dec - 25 Dec
Premium Suites Deluxe Aparthotel Equipetrol
Exterior detail
TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (145)
"Nice stay with good service "
United States
Jianyuan
The price is 2.605.185 ₫
2.605.185 ₫ total
24 Dec - 25 Dec
TRYP by Wyndham Santa Cruz
Massages
Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"Beautiful hotel"
Australia
Joanna
The price is 3.894.620 ₫
3.894.620 ₫ total
6 Jan - 7 Jan 2026
Swissôtel Santa Cruz De La Sierra
Outdoor pool
Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure

Delfines Collection Hotel By Mercure
3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (73)
"Excellent place to stay!"
United States
Luisa
The price is 1.223.121 ₫
1.223.121 ₫ total
27 Dec - 28 Dec
Delfines Collection Hotel By Mercure
Reception
Lido Hotel

Lido Hotel

Lido Hotel
3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is 931.822 ₫
931.822 ₫ total
1 Jan - 2 Jan 2026
Lido Hotel
Front of property
Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo

Alfonsina Hotel Boutique by Inboccaluppo
3.5 star property
Santa Cruz
9.4 out of 10, Exceptional, (40)
"Love it. Will stay again!!"
United States
Juan
The price is 2.788.259 ₫
2.788.259 ₫ total
1 Jan - 2 Jan 2026
Alfonsina Hotel Boutique by Inboccaluppo
Standard Room, 2 Single Beds | Premium bedding, minibar, in-room safe, desk
Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro

Hotel LP Santa Cruz Centro
3.0 star property
Santa Cruz
8.0 out of 10, Very good, (281)
"Clean, friendly staff"
United States
Giovanna
Hotel LP Santa Cruz Centro
Daily buffet breakfast (USD 10 per person)
Hotel LP Equipetrol

Hotel LP Equipetrol

Hotel LP Equipetrol
3.5 star property
Santa Cruz
8.2 out of 10, Very good, (201)
"Nice place to stay"
United States
Ricardo
Hotel LP Equipetrol
Triple Room | Free WiFi
Hotel Las Américas

Hotel Las Américas

Hotel Las Américas
3.0 star property
Santa Cruz
6.0 out of 10, (1)
"O chuveiro foi impossível tomar um.banho de qualidade "
Brazil
Jean
The price is 1.011.285 ₫
1.011.285 ₫ total
24 Dec - 25 Dec
Hotel Las Américas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Great weekend hotel deals in Santa Cruz

Showing deals for:2 Jan - 4 Jan

Image gallery for HOTEL OSHO

Reception

HOTEL OSHO

3.5 star property
Santa Cruz
9.2/10Wonderful (35 reviews)
10% off
Price is 1.109.146 ₫
2.218.292 ₫ total
HOTEL OSHO
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Top Santa Cruz Hotel Reviews

Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

10/10 Excellent
"Everything is perfect!! "
Guillaume 1-night trip
Posted 2 months ago
Apart Hotel Premium Suites Santa Cruz
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

10/10 Excellent
"Great folks with there. Clean rooms."
Gregory 3-night trip
Posted 4 months ago
Premium Suites Deluxe Aparthotel Equipetrol

Explore a world of travel with Expedia

Frequently asked questions

How much do hotels in Santa Cruz cost?
The season and factors like school holidays, Christmas and Easter can influence the price of a hotel in Santa Cruz. You can find cheap options from 931.822 ₫ in a few different ways on Expedia. First, key in the dates you'd like to go on holiday, then use the filters such as property type and amenities to refine your search. You can also sort by price, so the most inexpensive options appear at the top.
When is the best time to go to Santa Cruz?
If you're thinking of visiting in summer, reserve your Santa Cruz hotel between December and February. Temperatures during the summer here range from 22ºC to 31ºC. Santa Cruz has an oceanic climate, so pack appropriately.
Are there any luxury hotels in Santa Cruz?
Expedia has got some terrific stays for an indulgent escape in Santa Cruz, Santa Cruz, such as Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Check in and make use of amenities like concierge services, a garden and complimentary breakfast. Alternatively, treat yourself at Radisson Hotel Santa Cruz.
What are the top all-inclusive hotels in Santa Cruz?
If you're looking for a relaxed and worry-free escape, throw your bags down at Prince Hotel. Generally including your drinks, food and some recreational activities in the flat upfront rate, it's one of the best options for an all-inclusive retreat in Santa Cruz.
How can I find cheap hotels in Santa Cruz?
Discover inexpensive hotels with minimal effort by making use of our filter tool. Choose the "Price per night" box to view low-cost options in Santa Cruz. Another way is to take a look at our cheap hotels in Santa Cruz page. The lowest price available starts from 931.822 ₫ per night.
What are the best hotels in Santa Cruz for families?
Cosmopolitano Hotel Boutique is one of the top-rated hotels for families, located in Santa Cruz, Santa Cruz. Book here and take advantage of conveniences such as complimentary breakfast and a cafe. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is another favourite where kiddos are welcome. For more hotel options, fine-tune your search results by selecting "Family friendly" under the "Traveller experience" filter heading.
Why should I book my Santa Cruz hotel with Expedia?
Book your Santa Cruz hotel with Expedia and enjoy a world of options at unbeatable prices. Use our search filters to help you find exactly what you want, whether that's a 5-star escape or something a little more unique, like a houseboat, log cabin or villa! Join Expedia Rewards and you'll save 10% or more on over 100,000 hotels worldwide when you're signed in. Collect points on eligible bookings, which you can use to save on your next epic adventure. Plus, many of our hotels come with flexible cancellation policies, so you can rest easy if your plans happen to change.