Search Hotels Near Highlands Regional Medical Center, Prestonsburg

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
18 Dec - 19 Dec
Tomorrow
19 Dec - 20 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Highlands Regional Medical Center hotels

Desk, blackout curtains, iron/ironing board, free cots/infant beds
Comfort Suites Prestonsburg West

Comfort Suites Prestonsburg West

Comfort Suites Prestonsburg West
2.5 star property
8.4 km from Highlands Regional Medical Center
8.6 out of 10, Excellent, (688)
"Room clean and staff just excellent!"
United States
Stephanie
The price is 2.663.381 ₫
3.020.808 ₫ total
includes taxes & fees
22 Dec - 23 Dec
Comfort Suites Prestonsburg West
Exterior
Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Quality Inn & Suites Prestonsburg next to Mountain Arts Center

Quality Inn & Suites Prestonsburg next to Mountain Arts Center
2.5 star property
8.3 km from Highlands Regional Medical Center
8.0 out of 10, Very good, (359)
"Nice clean place. Great rooms and price. Very friendly staff. "
United States
Jason
The price is 2.751.590 ₫
3.120.852 ₫ total
includes taxes & fees
20 Dec - 21 Dec
Quality Inn & Suites Prestonsburg next to Mountain Arts Center
Lobby
Ramada Hotel & Conference Center by Wyndham Paintsville

Ramada Hotel & Conference Center by Wyndham Paintsville

Ramada Hotel & Conference Center by Wyndham Paintsville
2.5 star property
10.3 km from Highlands Regional Medical Center
8.8 out of 10, Excellent, (547)
"Beautiful hotel, wonderful breakfast and staff, couldnt be happier with our stay"
United States
Sandra
The price is 2.842.431 ₫
3.133.496 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Ramada Hotel & Conference Center by Wyndham Paintsville
Exterior
Super 8 by Wyndham Prestonsburg

Super 8 by Wyndham Prestonsburg

Super 8 by Wyndham Prestonsburg
2.0 star property
8.3 km from Highlands Regional Medical Center
6.4 out of 10, (517)
"Friendly staff, clean room. "
United States
Heather
The price is 1.700.983 ₫
1.875.164 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Super 8 by Wyndham Prestonsburg
Desk, iron/ironing board, cots/infant beds, rollaway beds
Days Inn by Wyndham Paintsville

Days Inn by Wyndham Paintsville

Days Inn by Wyndham Paintsville
2.0 star property
9.8 km from Highlands Regional Medical Center
7.6 out of 10, Good, (515)
"Had the greatest and most compassionate staff. "
United States
Jaime
The price is 1.790.508 ₫
1.973.855 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Days Inn by Wyndham Paintsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Highlands Regional Medical Center Hotel Reviews

Comfort Inn Pikeville

Comfort Inn Pikeville

10/10 Excellent
"Room was very clean. Breakfast was good as well. Lots of restaurants in the area along with stores. "
Felicia 1-night trip
Posted 2 months ago
Comfort Inn Pikeville

Hotels near other Highlands Regional Medical Center attractions

East Kentucky Science Center & Varia Planetarium

You can spend an afternoon browsing the exhibits at East Kentucky Science Center & Varia Planetarium in Prestonsburg. Discover the area's mountain views and sunrises.
See properties

Jenny Wiley State Resort Park

4.1/5 (58 reviews)
Explore the great outdoors at Jenny Wiley State Resort Park, a lovely green space in Prestonsburg. Wander the riverfront or discover the area's mountain views.
See properties

Frequently asked questions

What's the area like around Highlands Regional Medical Center?
Highlands Regional Medical Center is located in Prestonsburg. You'll find 15 hotels and other accommodations within a few miles for a convenient home base.
How many hotels can I expect to find near Highlands Regional Medical Center?
Expedia has 15 hotels and other accommodation options a few miles from Highlands Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Highlands Regional Medical Center, will I receive a refund?
Yes, you'll find most room reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can use the "fully refundable" filter to view the best deals near Highlands Regional Medical Center.
What can I see and do near Highlands Regional Medical Center?
You'll want to browse the exhibits at East Kentucky Science Center & Varia Planetarium and Loretta Lynn's Home. Sights like Loretta Lynn's Birthplace - Butcher Hollow and Samuel May House highlight some of the local culture. You might spend a leisurely day outdoors at Jenny Wiley State Resort Park and Archer Park.