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Our top choices for South Main hotels
Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,230 reviews)
"Front desk staff was very professional and kind."
MARINA
The price is 2.605.800 ₫
3.048.787 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,001 reviews)
"Clean room, helpful staff and good location to hospital."
George
The price is 3.203.571 ₫
3.748.178 ₫ total
includes taxes & fees
2 Apr - 3 Apr
Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Easy access to stadium "
Richard
The price is 1.824.060 ₫
2.134.151 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (837 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
Myra
The price is 2.267.046 ₫
2.652.444 ₫ total
includes taxes & fees
2 Apr - 3 Apr
Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,000 reviews)
"Courteous staff, clean room, quite property"
Javier
The price is 1.857.154 ₫
2.172.871 ₫ total
includes taxes & fees
2 Apr - 3 Apr
Courtyard by Marriott Houston Intercontinental Airport
Courtyard by Marriott Houston Intercontinental Airport31.8 km from South Main
9.0 out of 10, Wonderful, (1,183 reviews)
"This is the second time we’ve stayed here to fly out of IAH. "
Kadie
The price is 3.259.856 ₫
3.814.032 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,797 reviews)
"Great place "
Susan
The price is 2.472.644 ₫
2.908.324 ₫ total
includes taxes & fees
30 Mar - 31 Mar
Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (149 reviews)
"Room was clean, and the staff friendly "
Angie
The price is 2.168.026 ₫
2.536.226 ₫ total
includes taxes & fees
1 Apr - 2 Apr
Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Was a good hotel "
Kathy
The price is 2.030.439 ₫
2.375.615 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Palace Inn Blue Edgebrook
Palace Inn Blue Edgebrook16.8 km from South Main
9.4 out of 10, Exceptional, (155 reviews)
"Such a great place to stay! Absolutely amazing!"
Charlette
The price is 2.596.159 ₫
3.128.630 ₫ total
includes taxes & fees
3 Mar - 4 Mar
SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,670 reviews)
"Great place to stay "
Andrea
The price is 2.857.260 ₫
3.342.995 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Great staff and very clean hotel. "
Matthew
The price is 2.319.162 ₫
2.713.420 ₫ total
includes taxes & fees
25 Mar - 26 Mar
Doubletree by Hilton Houston Hobby Airport
Doubletree by Hilton Houston Hobby AirportSoutheast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,005 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
Wayne
The price is 2.970.091 ₫
3.508.881 ₫ total
includes taxes & fees
9 Mar - 10 Mar
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,086 reviews)
"Friendly Courteous Staff - Clean Rooms"
Dale
The price is 2.059.885 ₫
2.368.867 ₫ total
includes taxes & fees
5 Mar - 6 Mar
Hilton Garden Inn Houston Hobby Airport, TX
Hilton Garden Inn Houston Hobby Airport, TX15 km from South Main
8.8 out of 10, Excellent, (1,005 reviews)
"Clean, convenient, nice staff- very helpful"
Jo
The price is 2.788.988 ₫
3.263.116 ₫ total
includes taxes & fees
9 Mar - 10 Mar
Home2 Suites by Hilton Houston Pasadena
Home2 Suites by Hilton Houston Pasadena24.3 km from South Main
9.4 out of 10, Exceptional, (834 reviews)
"Loved the entire stay!"
Christian
The price is 2.523.717 ₫
2.952.751 ₫ total
includes taxes & fees
22 Mar - 23 Mar
La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.2 out of 10, Very good, (1,572 reviews)
"This was a great place to stay and at a good price "
Ashley
The price is 1.882.691 ₫
2.202.748 ₫ total
includes taxes & fees
30 Mar - 31 Mar
Spark by Hilton Houston Bush Intercontinental Airport
Spark by Hilton Houston Bush Intercontinental Airport31.2 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Rooms were clean, front desk ladies were helpful and friendly. Very convenient to airport. "
Heidi
The price is 2.863.253 ₫
3.350.006 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Palace Inn Blue Houston East Beltway 8
Palace Inn Blue Houston East Beltway 829.5 km from South Main
9.0 out of 10, Wonderful, (367 reviews)
"Hotel was very clean, decor was great, guest services was prompt and courteous. We will def stay coming through Houston again "
Desiree
The price is 1.876.176 ₫
2.157.602 ₫ total
includes taxes & fees
3 Mar - 4 Mar
Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"Place was amazing and the staff were great!!!"
Marlene
The price is 2.372.581 ₫
2.790.512 ₫ total
includes taxes & fees
27 Mar - 28 Mar
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
 Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,001 reviews | View | ||||||
 Candlewood Suites Houston Medical Center by IHG | 7.4 Good 837 reviews | View | ||||||
 Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,230 reviews | View | ||||||
 Wingate Houston near NRG Park/Medical Center | 6.6 1,000 reviews | View | ||||||
 Comfort Suites Near Texas Medical Center - NRG Stadium | 9.0 Wonderful 6 reviews | View |
Where to stay in South Main
Find the best South Main areas for the activities you enjoy most.
Downtown Houston
Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.
The Galleria
Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.
Texas Medical Center
Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.
Montrose
Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Top South Main Hotel Reviews
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
10/10 Excellent
