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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,230 reviews)
"Front desk staff was very professional and kind."
United States
MARINA
The price is 2.605.800 ₫
3.048.787 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Wyndham Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,001 reviews)
"Clean room, helpful staff and good location to hospital."
United States
George
The price is 3.203.571 ₫
3.748.178 ₫ total
includes taxes & fees
2 Apr - 3 Apr
Comfort Suites Houston near Medical Center- NRG Stadium

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,000 reviews)
"Easy access to stadium "
United States
Richard
The price is 1.824.060 ₫
2.134.151 ₫ total
includes taxes & fees
23 Mar - 24 Mar
Wingate Houston near NRG Park/Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (837 reviews)
"This is a safe, friendly hotel close to MDA Cancer Center"
United States
Myra
The price is 2.267.046 ₫
2.652.444 ₫ total
includes taxes & fees
2 Apr - 3 Apr
Candlewood Suites Houston Medical Center by IHG

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,000 reviews)
"Courteous staff, clean room, quite property"
United States
Javier
The price is 1.857.154 ₫
2.172.871 ₫ total
includes taxes & fees
2 Apr - 3 Apr
Quality Inn & Suites NRG Park - Medical Center

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,183 reviews)
"This is the second time we’ve stayed here to fly out of IAH. "
United States
Kadie
The price is 3.259.856 ₫
3.814.032 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Courtyard by Marriott Houston Intercontinental Airport

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,797 reviews)
"Great place "
United States
Susan
The price is 2.472.644 ₫
2.908.324 ₫ total
includes taxes & fees
30 Mar - 31 Mar
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.2 out of 10, Wonderful, (149 reviews)
"Room was clean, and the staff friendly "
United States
Angie
The price is 2.168.026 ₫
2.536.226 ₫ total
includes taxes & fees
1 Apr - 2 Apr
Best Western Plus Pearland/Houston Medical Center Hotel

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,002 reviews)
"Was a good hotel "
United States
Kathy
The price is 2.030.439 ₫
2.375.615 ₫ total
includes taxes & fees
15 Mar - 16 Mar
Tru by Hilton Houston Webster NASA

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (155 reviews)
"Such a great place to stay! Absolutely amazing!"
United States
Charlette
The price is 2.596.159 ₫
3.128.630 ₫ total
includes taxes & fees
3 Mar - 4 Mar
Palace Inn Blue Edgebrook

SpringHill Suites by Marriott Houston Intercontinental Arprt

SpringHill Suites by Marriott Houston Intercontinental Arprt
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,670 reviews)
"Great place to stay "
United States
Andrea
The price is 2.857.260 ₫
3.342.995 ₫ total
includes taxes & fees
22 Mar - 23 Mar
SpringHill Suites by Marriott Houston Intercontinental Arprt

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,003 reviews)
"Great staff and very clean hotel. "
United States
Matthew
The price is 2.319.162 ₫
2.713.420 ₫ total
includes taxes & fees
25 Mar - 26 Mar
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Doubletree by Hilton Houston Hobby Airport

Doubletree by Hilton Houston Hobby Airport
4.0 star property
Southeast Houston, 14.5 km from South Main
8.8 out of 10, Excellent, (1,005 reviews)
"Excellent stay! The room was very clean and comfortable, and the staff went above and beyond to be friendly and helpful. Check-in was smooth, the amenities were great, and the overall atmosphere made it a relaxing experience. I’d definitely stay here again!"
United States
Wayne
The price is 2.970.091 ₫
3.508.881 ₫ total
includes taxes & fees
9 Mar - 10 Mar
Doubletree by Hilton Houston Hobby Airport

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
3.0 star property
18.5 km from South Main
8.8 out of 10, Excellent, (1,086 reviews)
"Friendly Courteous Staff - Clean Rooms"
United States
Dale
The price is 2.059.885 ₫
2.368.867 ₫ total
includes taxes & fees
5 Mar - 6 Mar
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham

Hilton Garden Inn Houston Hobby Airport, TX

Hilton Garden Inn Houston Hobby Airport, TX
3.0 star property
15 km from South Main
8.8 out of 10, Excellent, (1,005 reviews)
"Clean, convenient, nice staff- very helpful"
United States
Jo
The price is 2.788.988 ₫
3.263.116 ₫ total
includes taxes & fees
9 Mar - 10 Mar
Hilton Garden Inn Houston Hobby Airport, TX

Home2 Suites by Hilton Houston Pasadena

Home2 Suites by Hilton Houston Pasadena
3.0 star property
24.3 km from South Main
9.4 out of 10, Exceptional, (834 reviews)
"Loved the entire stay!"
United States
Christian
The price is 2.523.717 ₫
2.952.751 ₫ total
includes taxes & fees
22 Mar - 23 Mar
Home2 Suites by Hilton Houston Pasadena

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very good, (1,572 reviews)
"This was a great place to stay and at a good price "
United States
Ashley
The price is 1.882.691 ₫
2.202.748 ₫ total
includes taxes & fees
30 Mar - 31 Mar
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Spark by Hilton Houston Bush Intercontinental Airport

Spark by Hilton Houston Bush Intercontinental Airport
3.0 star property
31.2 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Rooms were clean, front desk ladies were helpful and friendly. Very convenient to airport. "
United States
Heidi
The price is 2.863.253 ₫
3.350.006 ₫ total
includes taxes & fees
8 Mar - 9 Mar
Spark by Hilton Houston Bush Intercontinental Airport

Palace Inn Blue Houston East Beltway 8

Palace Inn Blue Houston East Beltway 8
2.5 star property
29.5 km from South Main
9.0 out of 10, Wonderful, (367 reviews)
"Hotel was very clean, decor was great, guest services was prompt and courteous. We will def stay coming through Houston again "
United States
Desiree
The price is 1.876.176 ₫
2.157.602 ₫ total
includes taxes & fees
3 Mar - 4 Mar
Palace Inn Blue Houston East Beltway 8

Hilton Garden Inn Houston/Bush Intercontinental Airport

Hilton Garden Inn Houston/Bush Intercontinental Airport
3.0 star property
31.1 km from South Main
8.4 out of 10, Very good, (1,003 reviews)
"Place was amazing and the staff were great!!!"
United States
Marlene
The price is 2.372.581 ₫
2.790.512 ₫ total
includes taxes & fees
27 Mar - 28 Mar
Hilton Garden Inn Houston/Bush Intercontinental Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,001 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
837 reviews
View
Premium bedding, pillow-top beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2
Good
1,230 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,000 reviews
View
Room
Comfort Suites Near Texas Medical Center - NRG Stadium
2.0 star property
9.0
Wonderful
6 reviews
View

Where to stay in South Main

Find the best South Main areas for the activities you enjoy most.

Downtown Houston

Gourmet restaurants acclaimed theatres and top sights from Toyota Center to Daikin Park – discover Downtown Houston, a destination also famous for its sports teams.

The Galleria

Travellers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to stop by The Galleria and Williams Tower.

Texas Medical Center

Well liked for its restaurants, museums and shopping, there's plenty to explore in Texas Medical Center. Attractions like Houston Zoo are a major draw, and you can hop on the metro at TMC Transit Center or Dryden/TMC Station to see more of the city.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more of the city at Bell Station or Downtown Transit Center Station.

Montrose

Unique features of Montrose include the theatres and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Top South Main Hotel Reviews

Frequently asked questions

What is South Main like?
You'll be sure to have fun exploring Houston's South Main neighbourhood. Consider a visit to NRG Park as part of your South Main travel plans.
How many hotels should I expect to find in South Main?
If you're searching for places to stay in Houston, Expedia has something to meet your needs with 63 South Main hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in South Main, will I receive a refund?
Yes, you'll find most hotel bookings are fully refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Add your dates and click on "Search", then filter by "fully refundable" to get the best options available in South Main.
What can I see and do in this Houston neighbourhood?
NRG Park is an attraction you might want to check out while you're in South Main. While you're out sightseeing in Houston, make sure that you visit other sights such as NRG Stadium or NRG Arena.
How can I get around South Main and the greater Houston area?
Ready to get out and explore the city? Fannin South Station is the closest metro station.