The Best Hotels in Illinois Medical District, Chicago - 2026 Updated Prices

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Our top choices for Illinois Medical District hotels

1. Hampton Inn & Suites Chicago Medical District UIC

Illinois Medical District

Alisa

4.980.048 ₫ total

includes taxes & fees

7 Sept - 8 Sept

2. Hyatt Place Chicago Medical/University District

Illinois Medical District

Hser

5.703.887 ₫ total

includes taxes & fees

7 Sept - 8 Sept

3. Hyatt House Chicago Medical/University District

Illinois Medical District

Daniel

6.478.870 ₫ total

includes taxes & fees

7 Sept - 8 Sept

4. Hyatt House Chicago/West Loop-Fulton Market

2.3 km from Illinois Medical District

Joel

7.656.845 ₫ total

includes taxes & fees

7 Sept - 8 Sept

5. Crowne Plaza Chicago West Loop by IHG

2.7 km from Illinois Medical District

Jaclyn

5.983.233 ₫ total

includes taxes & fees

7 Sept - 8 Sept

6. Hyatt Place Chicago/Downtown - The Loop

The Loop, 3.6 km from Illinois Medical District

LISA

6.168.878 ₫ total

includes taxes & fees

7 Sept - 8 Sept

7. Hyatt Centric The Loop Chicago

Theatre District, 3.9 km from Illinois Medical District

Tamika

6.579.253 ₫ total

includes taxes & fees

7 Sept - 8 Sept

8. La Quinta Inn & Suites by Wyndham Chicago Downtown

The Loop, 3.6 km from Illinois Medical District

Shilpa

5.548.797 ₫ total

includes taxes & fees

7 Sept - 8 Sept

55-inch LCD TV with cable channels, TV, pay films

9. L7 Chicago by LOTTE

Theatre District, 4.5 km from Illinois Medical District

Jeff

8.009.621 ₫ total

includes taxes & fees

20 Sept - 21 Sept

10. River Hotel

The Loop, 4.6 km from Illinois Medical District

Timothy

4.905.154 ₫ total

includes taxes & fees

7 Sept - 8 Sept

11. The Allegro Royal Sonesta Hotel Chicago Loop

Theatre District, 3.8 km from Illinois Medical District

Anthony

7.313.239 ₫ total

includes taxes & fees

7 Sept - 8 Sept

12. Homewood Suites by Hilton Chicago West Loop Fulton Mkt Area

3.1 km from Illinois Medical District

Amber

7.732.176 ₫ total

includes taxes & fees

11 Sept - 12 Sept

13. Hotel Riu Plaza Chicago

Streeterville, 5.1 km from Illinois Medical District

Donna

5.258.449 ₫ total

includes taxes & fees

7 Sept - 8 Sept

14. citizenM Chicago Downtown

Theatre District, 4.6 km from Illinois Medical District

lakadria

5.269.691 ₫ total

includes taxes & fees

8 Sept - 9 Sept

15. Sonesta ES Suites Chicago Downtown Magnificent Mile - Medical

Streeterville, 5.6 km from Illinois Medical District

Felicia

4.860.516 ₫ total

includes taxes & fees

8 Sept - 9 Sept

16. Hyatt Place Chicago/River North

River North, 4.4 km from Illinois Medical District

Shoma

6.137.876 ₫ total

includes taxes & fees

10 Sept - 11 Sept

17. Springhill Suites by Marriott Chicago Downtown/ River North

River North, 4.4 km from Illinois Medical District

Claudia

5.734.665 ₫ total

includes taxes & fees

7 Sept - 8 Sept

18. Holiday Inn Chicago Dwtn - The Mart by IHG

River North, 3.7 km from Illinois Medical District

Victor

6.757.801 ₫ total

includes taxes & fees

7 Sept - 8 Sept

Outdoor pool, pool cabanas (surcharge), pool umbrellas

19. DoubleTree by Hilton Chicago - Magnificent Mile

Streeterville, 5.3 km from Illinois Medical District

Tonya

4.929.211 ₫ total

includes taxes & fees

10 Sept - 11 Sept

20. Embassy Suites by Hilton Chicago Downtown River North

River North, 4.7 km from Illinois Medical District

Hugo

5.157.676 ₫ total

includes taxes & fees

7 Sept - 8 Sept

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Where to stay in Illinois Medical District

Find the best Illinois Medical District areas for the activities you enjoy most.

A busy city street with tall buildings, a bus, and cars.

Downtown Chicago

Known for its fascinating museums, stunning river views and gorgeous architecture, there's plenty to explore in Downtown Chicago. Top attractions like Navy Pier and Michigan Avenue are major draws. Catch the metro at State Station or Clark-Lake Station to see more of the city.

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A river with yellow boats, a bridge, and tall buildings.

The Loop

Michigan Avenue and Lake Michigan are a few top attractions in The Loop. Hop around the city on the metro at Washington Station or Lake Station and check out the area's fascinating museums, popular shops and acclaimed art galleries.

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A historic castle-like building with intricate stonework and a paved walkway.

Magnificent Mile

Are you interested in fascinating museums, panoramic lake views and popular shops? A visit to Magnificent Mile might be the perfect thing. You can also explore top sights like Michigan Avenue and Chicago Water Tower.

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A city street with a train passing overhead, cars, pedestrians, and a red brick building.

River North

Known for its fantastic nightlife, stunning river views and popular shops, there's plenty to explore in River North. Top attractions like Merchandise Mart and Bally's Casino Chicago are major draws. Catch the metro at Merchandise Mart Station or Chicago Station (Brown Line) to see more of the city.

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A river with a city skyline in the background, surrounded by green trees and grass.

Lincoln Park

Known for its ample dining options and fantastic lake views, there's plenty to explore in Lincoln Park. You can visit top attractions like Lake Michigan and Lincoln Hall, and jump on the metro at Fullerton Station or Armitage Station to see more of the city.

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Top Illinois Medical District Hotel Reviews

Hilton Chicago

8/10 Good

"The location was geeat"

L7 Chicago by LOTTE

10/10 Excellent

"We came down for the Jill Scott concert and stayed here add the hotel was literally 2 blocked from the venue Chicago Theater. We were on the 4th floor and the view was spectacular. The room had 2 queen beds and was very spacious, but what took my breath away was the bed area in the window. I slept here because I wanted to see the view. Valet parking was $65 a night which is cheaper than a lot of places in Chicago. I paid for breakfast at the hotel with the reservation, which was an Asian/American mix restaurant. There were conventional breakfast choices are well as Asian choices, I'm more of a conventional breakfast person. The price for breakfast was $50 extra per person. There were many people in there for breakfast so the place is pretty popular, but next time I'll just go to a restaurant nearby. We didn't stay for dinner so I'm not sure of the choices with that. I will most definitely stay here again, and will recommend to others. I think this hotel is my favorite in Chicago so far."

Frequently asked questions

What's it like in Illinois Medical District?

Guests are sure to enjoy their time checking out all that Chicago's Illinois Medical District neighbourhood has to offer.

How many hotels are there in the Illinois Medical District area?

If you're searching for places to stay in Chicago, choose from one of Expedia's 16 hotels and other accommodation options in Illinois Medical District.

If I need to cancel my hotel reservation in Illinois Medical District, will I receive a refund?

Yes, most room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, you might be able to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to view the top deals on offer in Illinois Medical District.

What can I see and do in this Chicago neighbourhood?

Don't miss favourite places to visit in the surrounding area, such as Soldier Field, United Center and Michigan Avenue. Malcolm X College and Michael Jordan Statue are also worth a visit when you're out sightseeing in Chicago.

How can I get around Illinois Medical District and the greater Chicago area?

Ready to get out and explore the city? Polk Station (Pink Line) is the closest metro station.

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Our top choices for Illinois Medical District hotels

1. Hampton Inn & Suites Chicago Medical District UIC

2. Hyatt Place Chicago Medical/University District

3. Hyatt House Chicago Medical/University District

4. Hyatt House Chicago/West Loop-Fulton Market

5. Crowne Plaza Chicago West Loop by IHG

6. Hyatt Place Chicago/Downtown - The Loop

7. Hyatt Centric The Loop Chicago

8. La Quinta Inn & Suites by Wyndham Chicago Downtown

9. L7 Chicago by LOTTE

10. River Hotel

11. The Allegro Royal Sonesta Hotel Chicago Loop

12. Homewood Suites by Hilton Chicago West Loop Fulton Mkt Area

13. Hotel Riu Plaza Chicago

14. citizenM Chicago Downtown

15. Sonesta ES Suites Chicago Downtown Magnificent Mile - Medical

16. Hyatt Place Chicago/River North

17. Springhill Suites by Marriott Chicago Downtown/ River North

18. Holiday Inn Chicago Dwtn - The Mart by IHG

19. DoubleTree by Hilton Chicago - Magnificent Mile

20. Embassy Suites by Hilton Chicago Downtown River North

Where to stay in Illinois Medical District

Downtown Chicago

The Loop

Magnificent Mile

River North

Lincoln Park

Top Illinois Medical District Hotel Reviews

Hilton Chicago

Frequently asked questions

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