Mark Twain Holidays

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Where to stay in Mark Twain

Find the best Mark Twain areas and neighborhoods for the activities you enjoy most. Learn more about Mark Twain

A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

The abundant dining options and forests are just a few top-rate features of the neighbourhood. Make a stop by World Chess Hall of Fame or Blue Strawberry while you're visiting, and jump aboard the metro at Central West End Station to get around town.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

While visiting Downtown West, you might make a stop by sights like St. Louis Union Station and St. Louis Aquarium at Union Station.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Top hotels in Mark Twain

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

3.502.156 ₫

4.130.057 ₫ total

28 Aug - 29 Aug

includes taxes & fees

8.6/10 Excellent! (4,254 reviews)

"I booked a room with two double beds that was confirmed by Expedia. I called the hotel five hours before my arrival to reconfirm my reservations as I was driving my son to college, Upon arrival, I was told they did not have rooms with two beds, I asked how this could be since my reservation stated ..."

Reviewed on 24 Aug 2026

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

2.437.652 ₫

2.845.667 ₫ total

6 Sept - 7 Sept

includes taxes & fees

8.8/10 Excellent! (3,375 reviews)

"Always clean, staff friendly, breakfast is good."

Reviewed on 24 Aug 2026

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Fully refundableReserve now, pay when you stay

2.608.647 ₫

3.819.572 ₫ total

1 Sept - 2 Sept

includes taxes & fees

8.6/10 Excellent! (2,248 reviews)

"Good location to events nice shuttle worth the money room clean ."

Reviewed on 23 Aug 2026

See all 1,991 properties in Mark Twain

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.