What is Matlacha Isles like?

Travellers will be sure to find plenty to entertain them in Cape Coral's Matlacha Isles neighbourhood.

How many hotels will I be able to find in the Matlacha Isles area?

When you want to put your feet up after a day of exploring the sights in Cape Coral, you can choose from 18 Expedia hotels and other accommodation options in Matlacha Isles.

If I need to cancel my hotel reservation in Matlacha Isles, will I receive a refund?

Yes, the majority of room reservations are fully refundable as long as you cancel before the hotel’s cancellation deadline, which often is within 24-48 hours of your check-in date. If you have a reservation that's non-refundable, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to get the best deals in Matlacha Isles.

What are the top things to see and do in Matlacha Isles?

A few places to visit in the area around Matlacha Isles include Griffen American Center for Haitian Art, Lovegrove Gallery & Gardens and Cape Royal Golf Club. While you're out sightseeing in Cape Coral, make sure that you visit other sights such as Little Dead Key or Big Dead Key.

The Best Hotels in Matlacha Isles, Cape Coral - 2026 Updated Prices

An aerial view of a coastal town with a marina, surrounded by water and green land.

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Our top choices for Matlacha Isles hotels

A waterfront hotel with multiple buildings, a dock, and a calm body of water reflecting the structures.

1. Marriott Sanibel Harbour Resort & Spa

17.2 km from Matlacha Isles

Yunior

7.351.614 ₫ total

includes taxes & fees

2 Nov - 3 Nov

A modern dining area with a central island, multiple tables, and chairs.

2. Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

Hancock, 11.5 km from Matlacha Isles

Mauricio

3.289.007 ₫ total

includes taxes & fees

22 Oct - 23 Oct

A large, clear swimming pool with multiple lounge areas and palm trees.

3. Margaritaville Beach Resort Fort Myers

23 km from Matlacha Isles

Jose

6.471.302 ₫ total

includes taxes & fees

21 Oct - 22 Oct

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a window with curtains.

4. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Downtown Cape Coral, 13.6 km from Matlacha Isles

MARYTE

2.915.039 ₫ total

includes taxes & fees

28 Oct - 29 Oct

A balcony with a table and chairs, large windows, and a view of the sea.

5. The Westin Cape Coral Resort At Marina Village

Pelican, 12.3 km from Matlacha Isles

Charles

5.379.071 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A swimming pool with a rock arch structure, a multi-story building with balconies, and palm trees in the background.

6. Pink Shell Beach Resort and Marina

21.7 km from Matlacha Isles

Mario

7.915.115 ₫ total

includes taxes & fees

15 Nov - 16 Nov

A modern kitchen area with a breakfast bar, fruit display, and a chalkboard menu.

7. Hampton Inn Fort Myers Downtown

17.6 km from Matlacha Isles

Jason

3.291.318 ₫ total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with round tables and chairs, ceiling fans, and a bar area with shelves of bottles.

8. Doubletree by Hilton Fort Myers at Bell Tower Shops

20.6 km from Matlacha Isles

James

3.042.031 ₫ total

includes taxes & fees

30 Oct - 31 Oct

A modern living room with a TV, dining table, and chairs. There is a balcony with a view of palm trees.

9. Casa Ybel Resort

24.1 km from Matlacha Isles

Yesenia

6.695.713 ₫ total

includes taxes & fees

21 Oct - 22 Oct

A beach with a variety of seashells and pebbles.

10. Sanibel Island Beach Resort

22.7 km from Matlacha Isles

Eldad

5.887.933 ₫ total

includes taxes & fees

27 Oct - 28 Oct

A modern hotel lobby with a seating area, a reception desk, and a dining area.

11. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Caloosahatchee, 12.3 km from Matlacha Isles

Michael

2.798.111 ₫ total

includes taxes & fees

27 Oct - 28 Oct

A spacious lobby with a high ceiling, a chandelier, and a reception desk in the background.

12. The Banyan Hotel Fort Myers, Tapestry Collection by Hilton

17.9 km from Matlacha Isles

George

3.527.486 ₫ total

includes taxes & fees

8 Nov - 9 Nov

An indoor swimming pool with clear water, a lifeguard station, and a seating area with chairs.

13. Comfort Inn & Suites Fort Myers Airport

27.9 km from Matlacha Isles

Erika

2.311.829 ₫ total

includes taxes & fees

26 Oct - 27 Oct

A beachfront hotel with a pool, beach, and ocean view.

14. DiamondHead Beach Resort

23.5 km from Matlacha Isles

Angela

6.792.520 ₫ total

includes taxes & fees

18 Nov - 19 Nov

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Where to stay in Matlacha Isles

Find the best Matlacha Isles areas for the activities you enjoy most.

A pier extending into the water with two gazebos at the end, under a sunset sky.

Pelican

While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.

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A coastal residential area with a marina, dense greenery, and high-rise buildings in the background.

Caloosahatchee

If you're spending some time in Caloosahatchee, Dolphin Marina and Cape Coral Yacht Club Beach are top sights worth seeing.

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A coastal cityscape with a beach, marina, and dense urban area.

Hancock

While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.

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A sunset over a calm lake with a dock and palm trees.

Yacht Club

While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby.

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A wooden pier extending into calm water with a clear sky and distant land.

Burnt Store

When in Burnt Store, you can plan a visit to Coral Oaks Golf Course and Burnt Store Marina, some noteworthy sights in the nearby area.

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Top Matlacha Isles Hotel Reviews

Hampton Inn Fort Myers-Airport & I-75

10/10 Excellent

"Súper tranquilo y buen ambiente"

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

8/10 Good

"The hotel location was great close to the beach. We had stayed there previous trips. Parking was plentiful close to room. Staff was very helpful with any issues we had. The only issue we really had was the AC was a bit noisy. Definitely, we will stay there again when we’re in the Fort Myers area and highly recommended to friends and family."

Pink Shell Beach Resort and Marina

10/10 Excellent

"Our stay at the Pink Shell was fantastic! We spent 5 nights with my Son, daughter in law and 2 Grandchildren. Wonderful resort for family. Plenty of activities for kids. Wonderful pools, restaurants and great beach for shelling. Friendly staff throughout! We hope to return sometime soon!"

Hilton Garden Inn Ft Myers

10/10 Excellent

"I stay often in Fort Myers (family), this is 1st at Garden Inn, I will definitely stay here in the future. Everything was immaculate, staff is friendly and ever so helpful. The rates were less than what I had been paying for someplace a few mins closer to the family. Discovered Garden Inn was <5 mins further, worth the extra few mins at less the cost. We ordered a breakfast to take to our room, cooked to order and plentiful."

Sanibel Island Beach Resort

8/10 Good

"Need to have Sanibel map of sites in each room, an outdoor shower to clean off sand near tiki hut would be great! Loved toiletries. Bar is a little pricey 2 small bloody marys and one appitiser of onion rings = $50 plus tip. Your remodel is fantastic. You will see us again for a 5 day stay with more girlfriends."

Search Hotels in Matlacha Isles, Cape Coral

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Our top choices for Matlacha Isles hotels

1. Marriott Sanibel Harbour Resort & Spa

2. Fairfield Inn & Suites by Marriott Cape Coral/North Fort Myers

3. Margaritaville Beach Resort Fort Myers

4. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

5. The Westin Cape Coral Resort At Marina Village

6. Pink Shell Beach Resort and Marina

7. Hampton Inn Fort Myers Downtown

8. Doubletree by Hilton Fort Myers at Bell Tower Shops

9. Casa Ybel Resort

10. Sanibel Island Beach Resort

11. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

12. The Banyan Hotel Fort Myers, Tapestry Collection by Hilton

13. Comfort Inn & Suites Fort Myers Airport

14. DiamondHead Beach Resort

Where to stay in Matlacha Isles

Pelican

Caloosahatchee

Hancock

Yacht Club

Burnt Store

Top Matlacha Isles Hotel Reviews

Hampton Inn Fort Myers-Airport & I-75

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