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Our top choices for Mayo Clinic Florida hotels

Lobby
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (447)
"Great facility to stay."
United States
Gary
The price is 3.920.935 ₫
4.450.261 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Breakfast, lunch, dinner served; American cuisine
Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (69)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is 3.453.709 ₫
3.919.959 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hilton Jacksonville At Mayo Clinic
Terrace/patio
TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (548)
"Very good hotel"
United States
Careli
The price is 2.999.910 ₫
3.404.898 ₫ total
includes taxes & fees
28 Dec - 29 Dec
TownePlace Suites by Marriott Jacksonville East
Lobby
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"very clean room, great staff, very quiet and a variety of breakfast options."
United States
Joy
The price is 2.675.709 ₫
3.036.929 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Lobby sitting area
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1000)
"Good location for a family vacation "
United States
Angel
The price is 2.763.075 ₫
3.136.090 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Terrace/patio
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very good, (755)
"Great location "
United States
Josiah Christine
The price is 4.236.715 ₫
4.808.673 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
BBQ/picnic Area
Salt Air Inn & Suites

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
7.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (409)
"A cute little gem with some of the best hospitality in the area. "
United States
Windy
Salt Air Inn & Suites
Property amenity
Element Jacksonville Beach

Element Jacksonville Beach

Element Jacksonville Beach
3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (523)
"The hotel was spotless as usual.The staff was fantastic incredible cleanliness"
United States
Robert
The price is 3.552.525 ₫
4.032.115 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Element Jacksonville Beach
Exterior
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1002)
"Great staff clean rooms. Excellent stay"
United States
Tina
The price is 3.368.320 ₫
3.823.043 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Property amenity
TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (66)
"This was an awesome place to stay."
United States
Christine
The price is 2.815.705 ₫
3.195.824 ₫ total
includes taxes & fees
28 Dec - 29 Dec
TownePlace Suites by Marriott® Jacksonville Mayport
Standard Room, 2 Queen Beds, Non Smoking | Down duvets, minibar, iron/ironing board, WiFi
The Hotel Palms

The Hotel Palms

The Hotel Palms
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
The price is 4.447.235 ₫
5.047.743 ₫ total
includes taxes & fees
6 Jan - 7 Jan 2026
The Hotel Palms
Exterior
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
2.5 star property
4.2 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"Good location for exploring Ponte Vedra and Jacksonville Beach areas."
United States
Julianne
The price is 3.171.252 ₫
3.599.371 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Lobby
Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3436)
"Great hotel"
United States
Gina
The price is 3.528.841 ₫
4.005.234 ₫ total
includes taxes & fees
8 Jan - 9 Jan 2026
Margaritaville Jacksonville Beach
Sports facility
Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1004)
"Quiet, near a lot of restaurants and shopping and all within walking distance. Staff was very friendly."
United States
Amber
The price is 2.926.228 ₫
3.321.270 ₫ total
includes taxes & fees
25 Dec - 26 Dec
Hyatt Place Jacksonville / St. Johns Town Center
Lounge
AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center

AC Hotel Jacksonville St Johns Town Center
2.5 star property
Southside, 8.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (166)
"Staff was excellent...highly recommend this Hotel"
Canada
Robert
The price is 4.315.660 ₫
4.898.275 ₫ total
includes taxes & fees
21 Dec - 22 Dec
AC Hotel Jacksonville St Johns Town Center
Couples treatment room(s), sauna, hot tub, steam room, body treatments
Ponte Vedra Inn & Club

Ponte Vedra Inn & Club

Ponte Vedra Inn & Club
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (813)
"Wonderful place to visit to relax. Very clean, very friendly and courteous staff. Great view from the balcony."
United States
Greg
The price is 10.499.685 ₫
12.470.284 ₫ total
includes taxes & fees
7 Jan - 8 Jan 2026
Ponte Vedra Inn & Club
Beach/ocean view
The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach

The Lodge and Club at Ponte Vedra Beach
5.0 star property
6.3 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (688)
"Clean room, excellent service and only steps from the ocean. The facility could use some TLC but, all in all, a wonderful place to stay. We’ll be back for sure. "
United States
Robert
The price is 10.499.685 ₫
12.470.284 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
The Lodge and Club at Ponte Vedra Beach
On the beach
Best Western Oceanfront

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1005)
"Great location, clean, comfortable bed, friendly staff"
United States
Jeff
The price is 3.197.009 ₫
3.628.605 ₫ total
includes taxes & fees
21 Dec - 22 Dec
Best Western Oceanfront
Free daily buffet breakfast
Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1002)
"The room was very clean, spacious and there was a good variety offered for breakfast. "
United States
Shelley
The price is 2.921.964 ₫
3.316.429 ₫ total
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Jacksonville Beach by IHG
Property amenity
Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
Deerwood, 9.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1005)
"Great stay and great customer service"
United States
Rebecca
The price is 2.505.188 ₫
2.843.389 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Sheraton Jacksonville Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mayo Clinic Florida Hotel Reviews

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic

10/10 Excellent
"The hotel is brand new. The design, finishes, and colors are well chosen. The hotel is on the Mayo campus, and the Mayo shuttle comes every 15 minutes. The restaurant located at the hotel was fantastic, the food was delicious and well prepared. All the employees at the hotel were very polite, helpful, and obviously invested in making that Hilton stand out. I really enjoyed my stay there."
Marc 1-night trip
Posted 2 days ago
Hilton Jacksonville At Mayo Clinic

Hotels near other Mayo Clinic Florida attractions

Adventure Landing

4.1/5 (157 reviews)
Have a fun-filled day with the family at Adventure Landing as part of your trip to Jacksonville Beach. Stroll along the beautiful beaches or seek out the golf courses.
See properties

Windsor Parke Golf Club

Enjoy a round of golf in Jacksonville at Windsor Parke Golf Club. Amble around the area's beautiful beaches or attend a sporting event.
See properties

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 45 hotels and other accommodation options you'll find within a mile.
How many hotels are there near Mayo Clinic Florida?
Expedia has 45 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can enjoy live performances at Players by the Sea and Wilson Center For the Arts. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.

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