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Our top choices for Mayo Clinic hotels

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Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area

Hilton Rochester Mayo Clinic Area
3.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.6 out of 10, Exceptional, (547)
"Very courteous staff, loved the valet guy!"
United States
Jean
The price is 4.510.036 ₫
5.192.180 ₫ total
includes taxes & fees
3 Jan - 4 Jan 2026
Hilton Rochester Mayo Clinic Area
Property amenity
TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area

TownePlace Suites by Marriott Rochester Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (483)
"Room was large, clean, beds were comfortable. Downstairs cafe and seating areas were very comfortable."
United States
Ann
The price is 3.342.132 ₫
3.847.629 ₫ total
includes taxes & fees
10 Jan - 11 Jan 2026
TownePlace Suites by Marriott Rochester Mayo Clinic Area
View from property
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
2.5 star property
Kutzky Park, 1.8 km from Mayo Clinic
9.6 out of 10, Exceptional, (678)
"Good place to stay when traveling to Mayo apots"
United States
Carolyn
The price is 2.342.124 ₫
2.696.371 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys
Terrace/patio
The Berkman

The Berkman

The Berkman
3.0 star property
Folwell, 1.4 km from Mayo Clinic
9.6 out of 10, Exceptional, (372)
"Staff was great, as was the room."
United States
Scott
The price is 4.402.930 ₫
5.119.399 ₫ total
includes taxes & fees
26 Dec - 27 Dec
The Berkman
Courtyard
EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG

EVEN Hotel Rochester - Mayo Clinic Area by IHG
4.0 star property
Kutzky Park, 1 km from Mayo Clinic
9.4 out of 10, Exceptional, (964)
"Rooms are comfortable and staff was was so professional and helpful."
United States
William
The price is 2.438.177 ₫
2.859.584 ₫ total
includes taxes & fees
26 Dec - 27 Dec
EVEN Hotel Rochester - Mayo Clinic Area by IHG
Terrace/patio
Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area

Home2 Suites by Hilton Rochester Mayo Clinic Area
3.0 star property
2.6 km from Mayo Clinic
9.6 out of 10, Exceptional, (884)
"Great stay,clean and friendly"
United States
Janet
The price is 2.999.498 ₫
3.453.171 ₫ total
includes taxes & fees
31 Dec - 1 Jan 2026
Home2 Suites by Hilton Rochester Mayo Clinic Area
Terrace/patio
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester, 0.5 km from Mayo Clinic
9.2 out of 10, Wonderful, (1003)
"Quick and easy check-in, walkable area and nice breakfast and accomodations. Would stay again!"
United States
Elizabeth
The price is 3.394.764 ₫
3.908.223 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Hyatt House Rochester/Mayo Clinic Area
Courtyard
Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Staybridge Suites Rochester - Mayo Clinic Area by IHG
3.0 star property
Kutzky Park, 1 km from Mayo Clinic
9.4 out of 10, Exceptional, (423)
"This was an amazing find in Rochester. Looking forward to staying here again. "
United States
Kellie
The price is 2.773.706 ₫
3.245.860 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Staybridge Suites Rochester - Mayo Clinic Area by IHG
BBQ/picnic Area
Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South

Residence Inn by Marriott Rochester Mayo Clinic Area South
3.0 star property
2.6 km from Mayo Clinic
9.6 out of 10, Exceptional, (254)
"Rooms were clean staff was courteous. "
United States
Michael
The price is 3.368.448 ₫
3.877.925 ₫ total
includes taxes & fees
30 Dec - 31 Dec
Residence Inn by Marriott Rochester Mayo Clinic Area South
Fridge, microwave, oven, stovetop
Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham

Broadway Plaza, Trademark Collection by Wyndham
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
9.2 out of 10, Wonderful, (167)
"Great staff, clean room, spacious kitchen and living room."
United States
silvia
The price is 4.078.980 ₫
4.695.927 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Broadway Plaza, Trademark Collection by Wyndham
Exterior
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys

Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (771)
"Clean room and housekeeping service was excellent"
United States
Dawn
The price is 2.210.544 ₫
2.544.889 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Courtyard by Marriott Rochester Mayo Clinic Area/Saint Marys
Terrace/patio
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys

Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
3.0 star property
Kutzky Park, 1.4 km from Mayo Clinic
9.2 out of 10, Wonderful, (477)
"Clean room, breakfast selection"
United States
Sonya
The price is 2.881.076 ₫
3.316.839 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Homewood Suites by Hilton Rochester Mayo Clinic Area / Saint Marys
Desk, iron/ironing board, free WiFi, bed sheets
Brentwood Inn & Suites

Brentwood Inn & Suites

Brentwood Inn & Suites
2.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (1002)
"Convenient, clean location and friendly staff"
United States
Kaushika
The price is 2.960.550 ₫
3.408.185 ₫ total
includes taxes & fees
26 Dec - 27 Dec
Brentwood Inn & Suites
Exterior
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (892)
"Room was clean and comfortable Staff courteous Comfortable beds Great restaurant"
United States
Matney
The price is 2.026.332 ₫
2.332.815 ₫ total
includes taxes & fees
24 Jan - 25 Jan 2026
Hotel Indigo Rochester – Mayo Clinic Area by IHG
Breakfast served
Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN

Hilton Garden Inn Rochester Downtown, MN
3.0 star property
Downtown Rochester, 0.3 km from Mayo Clinic
8.8 out of 10, Excellent, (853)
"Everything was wonderful! Helpful, friendly staff, great location, nice amenities."
United States
kristi
The price is 2.816.601 ₫
3.242.612 ₫ total
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Rochester Downtown, MN
Front of property
Aspen Suites

Aspen Suites

Aspen Suites
3.0 star property
1.2 km from Mayo Clinic
9.0 out of 10, Wonderful, (695)
"Room was clean and inviting and staff always willing to help"
United States
Maria del Carmen
The price is 4.078.717 ₫
4.930.303 ₫ total
includes taxes & fees
9 Jan - 10 Jan 2026
Aspen Suites
Exterior
Candlewood Suites Rochester Mayo Clinic Area by IHG

Candlewood Suites Rochester Mayo Clinic Area by IHG

Candlewood Suites Rochester Mayo Clinic Area by IHG
2.5 star property
2.6 km from Mayo Clinic
9.2 out of 10, Wonderful, (454)
"The staff checking in and out were helpful and friendly. The room was clean, comfortable, and quiet. "
United States
Allison
The price is 2.552.652 ₫
2.938.741 ₫ total
includes taxes & fees
13 Jan - 14 Jan 2026
Candlewood Suites Rochester Mayo Clinic Area by IHG
Terrace/patio
Hampton Inn Rochester-South

Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
2.9 km from Mayo Clinic
9.0 out of 10, Wonderful, (1001)
"We had a wonderful stay!"
United States
Sarah
The price is 2.117.806 ₫
2.438.124 ₫ total
includes taxes & fees
24 Jan - 25 Jan 2026
Hampton Inn Rochester-South
Free daily full breakfast
Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
3 km from Mayo Clinic
9.0 out of 10, Wonderful, (902)
"Staff was great. Great value for the cost. "
United States
Damon
The price is 1.833.164 ₫
2.110.430 ₫ total
includes taxes & fees
2 Jan - 3 Jan 2026
Econo Lodge Mayo Clinic Area
Exterior
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG

Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
2.5 star property
Kutzky Park, 1.6 km from Mayo Clinic
8.8 out of 10, Excellent, (765)
"Clean room, friendly staff. The only minus is the lighting in the bathroom, way too dim. "
United States
Stacy
The price is 2.500.020 ₫
2.878.148 ₫ total
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express & Suites Rochester – Mayo Clinic Area by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mayo Clinic Hotel Reviews

Hotels near other Mayo Clinic attractions

Soldiers Field Veterans Memorial

4.5/5 (30 reviews)
You can learn about the history of Rochester when you stop by Soldiers Field Veterans Memorial. Attend a sporting event or simply visit the area's shops.
See properties

Plummer Building

You can find out about the history of Rochester when you stop by Plummer Building.
See properties

Frequently asked questions

What's the area like around Mayo Clinic?
Mayo Clinic is located in a welcoming area of Rochester known for its major shopping area. If you're looking for a convenient place to stay, take a look at the 158 hotels and other accommodation options you'll find within a mile.
How many hotels should I expect to find near Mayo Clinic?
Expedia has 158 hotels and other accommodation options within a mile from Mayo Clinic.
If I need to cancel the hotel reservation for my stay near Mayo Clinic, will I receive a refund?
Yes, most hotel bookings are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Mayo Clinic.
What can I see and do near Mayo Clinic?
You'll want to browse the exhibits at Mayowood Mansion and History Center of Olmsted County. Learn about local history at Assisi Heights and Plummer House. You can enjoy live performances at Rochester Civic Theater and Marcus Rochester Cinema.

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